Allspice - Plavix (Clopidogrel) Interaction
Herbal: Allspice
Also Known As: Pimenta dioica, All Spice, Allspice Essential Oil, Aqua Pimentae, Clove Pepper, Eugenia Piment, Jamaica Pepper, Jamaican Pepper, Kiln-Dried Allspice, Piment de la Jamaïque, Pimenta, Pimento, Pimienta de Jamaica, Poivre Anglais, Poivre Aromatique, Poivre de Jamaïque
Drug: Clopidogrel
Brand names:
Plavix
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 20, 2025
Interaction Details
Clopidogrel is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, combining allspice with an antiplatelet or anticoagulant drug might increase the risk of bleeding.
Eugenol, a constituent of allspice, is reported to have antiplatelet activity. However, this interaction has yet not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33.
Allspice Overview
Allspice (Pimenta dioica) is a tropical evergreen tree that is native to Central America and the Caribbean. It belongs to the myrtle family (Myrtaceae). The fruit of the allspice tree is a small, round berry that is green when unripe and turns a reddish-brown color when ripe. The dried berries of the tree are most often used as a spice in cooking, while both the berries and leaves have been used in traditional medicine for their purported inflammatory, analgesic, and digestive properties.
Clopidogrel Overview
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Clopidogrel is used alone or with aspirin to prevent serious or life-threatening problems with the heart and blood vessels in people who have had a stroke, heart attack, or severe chest pain. This includes people who have percutaneous coronary intervention (PCI; angioplasty; a type of heart surgery) that may involve inserting coronary stents (metal tubes surgically placed in clogged blood vessels to improve blood flow) or who have coronary artery bypass grafting (CABG; a type of heart surgery). Clopidogrel is also used to prevent serious or life-threatening problems with the heart and blood vessels in people who have peripheral arterial disease (poor circulation in the blood vessels that supply blood to the legs). Clopidogrel is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
Allspice - More Interactions
Allspice interacts with 120 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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