Drug & supplement interaction

Apoaequorin + Ivabradine

Ivabradine brand names: Procoralan, Coralan, Corlentor, Corlanor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Apoaequorin and Ivabradine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ivabradine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Apoaequorin and Ivabradine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ivabradine and Apoaequorin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Apoaequorin at all — not against Ivabradine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Apoaequorin safety at a glance

Apoaequorin overall Use caution Generally well tolerated in short-term studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis
Prevagen bottle

Based on the current research available, apoaequorin, the protein derived from jellyfish that is the active ingredient in Prevagen, is not known to interact with any drugs.

This lack of interactions is likely due to the fact that apoaequorin is a relatively small and simple protein that does not have any known drug-binding sites or enzymatic activity.

Additionally, safety studies in animals have shown that even very large doses of apoaequorin don't appear to affect any organs or blood chemistry.

However, overall, there is limited data on its potential interactions with other drugs.

If someone is taking apoaequorin as a dietary supplement, they should still consult with a healthcare professional before starting to take it, especially if they are currently taking any medications or have any underlying medical conditions.

As with any dietary supplement, it is important to follow recommended dosages and to use it only as directed.

References

  • Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats. Sage Journals
  • Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats. PubMed

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Still wondering about combining Ivabradine and Apoaequorin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Apoaequorin and Ivabradine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Apoaequorin

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) has been reported to cause hypertension, hypotension, chest pain, and irregular heart rate, but it is unclear if these events were due to apoaequorin.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

    Ivabradine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivabradine. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Apoaequorin

    Recorded for Apoaequorin in the same Natural Medicines adverse-effect record shown under Raised blood pressure above.

    Ivabradine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivabradine. Read the label on DailyMed ›

  • Dizziness Additional detail

    Apoaequorin

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) has been reported to cause headache and dizziness in one clinical study at a rate of 18.8% and 7.6%, respectively. Memory impairment and insomnia were also reported. However, it is unclear how these rates compare with placebo.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

    Ivabradine

    Listed in the ADVERSE REACTIONS section of the FDA label for Ivabradine. Read the label on DailyMed ›

Reported for Apoaequorin but not commonly for Ivabradine: memory problems, stomach pain, chest pain and diarrhea.

Effects for Ivabradine come from the ADVERSE REACTIONS section of its FDA label; effects for Apoaequorin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Ivabradine Products Have a Food Rule — Apoaequorin Should Not Break It

At least one FDA label for a product containing Ivabradine says to take it with food. If you take Apoaequorin on an empty stomach out of habit, keep them separate — and take Ivabradine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ivabradine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINIST R ATION Adult and pediatric patients greater than 40 kg Starting dose is 2.5 (pediatrics and vulnerable adults) or 5 mg twice daily with food.

From the Dosage and Administration section of the FDA label we read for Ivabradine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ivabradine

This page covers Apoaequorin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ivabradine page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

Open the Ivabradine interaction page

One more smart check

Taking Apoaequorin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Apoaequorin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apoaequorin. Even though Apoaequorin itself has no known interaction with Ivabradine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Apoaequorin and Ivabradine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Apoaequorin
Top half

#632 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ivabradine
Top 25%

#430 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apoaequorin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Apoaequorin and Ivabradine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Apoaequorin

What is Apoaequorin?

Apoaequorin
  • Age-related memory concerns
  • General cognitive support
  • Brain health
  • Mild forgetfulness

Apoaequorin is a jellyfish-derived protein marketed (as Prevagen) to support memory and brain health. The scientific evidence that it improves memory is weak and largely comes from industry-funded studies, and as a protein it is likely broken down during digestion. Talk with your pharmacist or doctor before using it, especially if you have memory problems that need medical evaluation.

A synthetic version of a protein originally found in the jellyfish Aequorea victoria · Capsules, chewable tablets

An interaction check asks whether these two react with each other — it does not ask whether Apoaequorin is a good idea for someone in your situation. Here is what our Apoaequorin record says about it on its own.

Apoaequorin: dosing

There is no officially established or standardized dose for apoaequorin. Taking more than the labeled amount has no proven benefit and is not recommended.

From our Apoaequorin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Apoaequorin monograph & all interactions
Medication

About Ivabradine

What Is Ivabradine Used For?

Brand names: Procoralan, Coralan, Corlentor, Corlanor

Ivabradine (including the brand Corlanor) is used in adults with stable, symptomatic chronic heart failure with reduced pumping function to reduce the risk of being hospitalized for worsening heart failure. It is prescribed when the heart is beating too fast at rest and the patient is either already on the highest tolerated dose of a beta-blocker or cannot take one.

Corlanor is also approved to treat stable, symptomatic heart failure caused by dilated cardiomyopathy (an enlarged, weakened heart muscle) in children ages 6 months and older who have an elevated heart rate.

See full Ivabradine drug information
Keep checking

Other Drugs & Apoaequorin

Browse every other medication we’ve checked against Apoaequorin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Apoaequorin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Apoaequorin list.

See the full Apoaequorin interactions page
See every supplement checked against Ivabradine, ranked by severity
Evidence & sources

Apoaequorin References

The 1 references that drive our Apoaequorin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Apoaequorin and Ivabradine Together: Common Questions

Is it safe to take Apoaequorin with Ivabradine?
We do not list a known interaction between Apoaequorin and Ivabradine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Apoaequorin and Ivabradine have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Apoaequorin and Ivabradine at the same time of day?
At least one FDA label for a product containing Ivabradine says to take it with food. If you take Apoaequorin on an empty stomach out of habit, keep them separate and take Ivabradine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ivabradine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Ivabradine interact with any supplements?
Yes. Ivabradine has documented interactions with 138 supplements in our database — Apoaequorin is not one of them. The Ivabradine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Apoaequorin monograph Uses, safety profile, and every drug interaction in one place Ivabradine drug information The full plain-English guide to this medication Ivabradine supplement interactions Every supplement checked against Ivabradine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ivabradine and Apoaequorin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.