Drug & supplement interaction

Apoaequorin + Mitomycin

Mitomycin brand names: Mutamycin, Mitosol, Jelmyto.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Apoaequorin and Mitomycin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Apoaequorin and Mitomycin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mitomycin and Apoaequorin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Apoaequorin at all — not against Mitomycin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Apoaequorin safety at a glance

Apoaequorin overall Use caution Generally well tolerated in short-term studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis
Prevagen bottle

Based on the current research available, apoaequorin, the protein derived from jellyfish that is the active ingredient in Prevagen, is not known to interact with any drugs.

This lack of interactions is likely due to the fact that apoaequorin is a relatively small and simple protein that does not have any known drug-binding sites or enzymatic activity.

Additionally, safety studies in animals have shown that even very large doses of apoaequorin don't appear to affect any organs or blood chemistry.

However, overall, there is limited data on its potential interactions with other drugs.

If someone is taking apoaequorin as a dietary supplement, they should still consult with a healthcare professional before starting to take it, especially if they are currently taking any medications or have any underlying medical conditions.

As with any dietary supplement, it is important to follow recommended dosages and to use it only as directed.

References

  • Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats. Sage Journals
  • Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats. PubMed

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Still wondering about combining Mitomycin and Apoaequorin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Apoaequorin and Mitomycin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Apoaequorin

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) has been reported to cause hypertension, hypotension, chest pain, and irregular heart rate, but it is unclear if these events were due to apoaequorin.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

    Mitomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitomycin. Read the label on DailyMed ›

  • Stomach pain Additional detail

    Apoaequorin

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) was reported to cause mild diarrhea, nausea, and stomach pain in one study. Nausea occurred at a rate of 6.8%, diarrhea at a rate of 3.2%, and stomach pain at a rate of 2.2%. However, it is unclear how these rates compare with placebo.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

    Mitomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitomycin. Read the label on DailyMed ›

  • Nausea Additional detail

    Apoaequorin

    “Orally, apoaequorin seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Dizziness, headache, and nausea.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in cluster headache.

    Mitomycin

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitomycin. Read the label on DailyMed ›

Reported for Apoaequorin but not commonly for Mitomycin: memory problems, low blood pressure, chest pain and dizziness.

Effects for Mitomycin come from the ADVERSE REACTIONS section of its FDA label; effects for Apoaequorin come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Mitomycin

This page covers Apoaequorin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mitomycin page lists 26 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Acerola (moderate), Alpha-lipoic Acid (moderate), Coffee Charcoal (moderate) and Dimethylsulfoxide (dmso) (moderate).

By severity: 1 major · 15 moderate · 10 minor.

From our pharmacist’s overview on the Mitomycin page

“Activated charcoal is the entry to know first with mitomycin (Mutamycin, Mitosol, Jelmyto), a chemotherapy drug, because charcoal binds medications and can cut the amount the body receives, and it carries this list's only major rating. A weakened dose of a cancer treatment is a real loss, so I would treat these 26 interactions with gen…”

Reviewed by 2 · Jul 18, 2026

Open the Mitomycin interaction page

One more smart check

Taking Apoaequorin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Apoaequorin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apoaequorin. Even though Apoaequorin itself has no known interaction with Mitomycin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Apoaequorin and Mitomycin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Apoaequorin
Steady interest

#821 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mitomycin
Top 25%

#305 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apoaequorin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Apoaequorin and Mitomycin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Apoaequorin

What is Apoaequorin?

Apoaequorin
  • Age-related memory concerns
  • General cognitive support
  • Brain health
  • Mild forgetfulness

Apoaequorin is a jellyfish-derived protein marketed (as Prevagen) to support memory and brain health. The scientific evidence that it improves memory is weak and largely comes from industry-funded studies, and as a protein it is likely broken down during digestion. Talk with your pharmacist or doctor before using it, especially if you have memory problems that need medical evaluation.

A synthetic version of a protein originally found in the jellyfish Aequorea victoria · Capsules, chewable tablets

An interaction check asks whether these two react with each other — it does not ask whether Apoaequorin is a good idea for someone in your situation. Here is what our Apoaequorin record says about it on its own.

Apoaequorin: dosing

There is no officially established or standardized dose for apoaequorin. Taking more than the labeled amount has no proven benefit and is not recommended.

From our Apoaequorin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Apoaequorin monograph & all interactions
Medication

About Mitomycin

What Is Mitomycin Used For?

Brand names: Mutamycin, Mitosol, Jelmyto

Mitomycin (and its brand Mutamycin) is used intravenously in combination with other chemotherapy drugs to treat disseminated adenocarcinoma (a type of cancer that has spread) of the stomach or pancreas, when other treatments have not worked. It is not intended to replace surgery or radiation therapy.

Mitomycin is also the active ingredient in other products for different uses: Jelmyto treats low-grade upper tract urothelial cancer (cancer of the upper urinary tract); Zusduri treats recurrent low-grade intermediate-risk non-muscle invasive bladder cancer; and Mitosol is used as a surgical aid during certain glaucoma eye surgery. These are separate products with distinct indications and are not interchangeable with the intravenous injection form.

See full Mitomycin drug information
Keep checking

Other Drugs & Apoaequorin

Browse every other medication we’ve checked against Apoaequorin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Apoaequorin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Apoaequorin list.

See the full Apoaequorin interactions page
See every supplement checked against Mitomycin, ranked by severity
Evidence & sources

Apoaequorin References

The 1 references that drive our Apoaequorin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Apoaequorin and Mitomycin Together: Common Questions

Is it safe to take Apoaequorin with Mitomycin?
We do not list a known interaction between Apoaequorin and Mitomycin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Apoaequorin and Mitomycin have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Mitomycin interact with any supplements?
Yes. Mitomycin has documented interactions with 26 supplements in our database — Apoaequorin is not one of them. The Mitomycin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Apoaequorin monograph Uses, safety profile, and every drug interaction in one place Mitomycin drug information The full plain-English guide to this medication Mitomycin supplement interactions Every supplement checked against Mitomycin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mitomycin and Apoaequorin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.