Apoaequorin + Trilaciclib Dihydrochloride
Trilaciclib Dihydrochloride brand name: Cosela.
We found no known interaction between Apoaequorin and Trilaciclib Dihydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Apoaequorin and Trilaciclib Dihydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Trilaciclib Dihydrochloride and Apoaequorin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Apoaequorin at all — not against Trilaciclib Dihydrochloride, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Apoaequorin safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Based on the current research available, apoaequorin, the protein derived from jellyfish that is the active ingredient in Prevagen, is not known to interact with any drugs.
This lack of interactions is likely due to the fact that apoaequorin is a relatively small and simple protein that does not have any known drug-binding sites or enzymatic activity.
Additionally, safety studies in animals have shown that even very large doses of apoaequorin don't appear to affect any organs or blood chemistry.
However, overall, there is limited data on its potential interactions with other drugs.
If someone is taking apoaequorin as a dietary supplement, they should still consult with a healthcare professional before starting to take it, especially if they are currently taking any medications or have any underlying medical conditions.
As with any dietary supplement, it is important to follow recommended dosages and to use it only as directed.
References
- Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats. Sage Journals
- Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats. PubMed
See Every Supplement That Interacts With Trilaciclib Dihydrochloride
This page covers Apoaequorin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trilaciclib Dihydrochloride page lists 13 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).
By severity: 6 major · 7 moderate.
From our pharmacist’s overview on the Trilaciclib Dihydrochloride page
“Trilaciclib (Cosela) is an infusion given before chemotherapy to shield bone marrow in people with small cell lung cancer, and its supplement list deserves genuine attention because all 13 flagged ingredients press on the same weak point, the heart's electrical rhythm. Each can lengthen the QT interval, the pause between beats on an EC…”
Reviewed by 2 · Jul 18, 2026
Taking Apoaequorin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 28 real supplement products containing Apoaequorin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apoaequorin. Even though Apoaequorin itself has no known interaction with Trilaciclib Dihydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Apoaequorin and Trilaciclib Dihydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#700 of 1,452 supplements looked up here in the last 7 days
#491 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apoaequorin reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Apoaequorin and Trilaciclib Dihydrochloride records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Apoaequorin
What is Apoaequorin?
- Age-related memory concerns
- General cognitive support
- Brain health
- Mild forgetfulness
Apoaequorin is a jellyfish-derived protein marketed (as Prevagen) to support memory and brain health. The scientific evidence that it improves memory is weak and largely comes from industry-funded studies, and as a protein it is likely broken down during digestion. Talk with your pharmacist or doctor before using it, especially if you have memory problems that need medical evaluation.
A synthetic version of a protein originally found in the jellyfish Aequorea victoria · Capsules, chewable tablets
An interaction check asks whether these two react with each other — it does not ask whether Apoaequorin is a good idea for someone in your situation. Here is what our Apoaequorin record says about it on its own.
Apoaequorin: dosing
There is no officially established or standardized dose for apoaequorin. Taking more than the labeled amount has no proven benefit and is not recommended.
From our Apoaequorin monograph — the full record covers uses, side effects and every documented interaction.
About Trilaciclib Injection
What Is Trilaciclib Injection Used For?
Brand name: Cosela
Cosela (trilaciclib) is given to adults with extensive-stage small cell lung cancer (ES-SCLC) to decrease chemotherapy-induced myelosuppression — meaning it helps protect the bone marrow from the blood-cell-lowering effects of certain chemotherapy regimens.
Cosela is approved for use before platinum/etoposide-containing chemotherapy regimens or topotecan-containing regimens in ES-SCLC. It is given as an intravenous infusion before chemotherapy on each day that chemotherapy is administered.
Other Drugs & Apoaequorin
Browse every other medication we’ve checked against Apoaequorin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Apoaequorin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Apoaequorin list.
Apoaequorin References
The 1 references that drive our Apoaequorin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Apoaequorin and Trilaciclib Dihydrochloride Together: Common Questions
Is it safe to take Apoaequorin with Trilaciclib Dihydrochloride?
Do Apoaequorin and Trilaciclib Dihydrochloride have any of the same side effects?
Does Trilaciclib Dihydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Trilaciclib Dihydrochloride and Apoaequorin?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.