Drug & supplement interaction

Arenaria Rubra + Afatinib Dimaleate

Afatinib Dimaleate brand name: Gilotrif.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Arenaria Rubra and Afatinib Dimaleate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Arenaria Rubra and Afatinib Dimaleate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Afatinib Dimaleate and Arenaria Rubra in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arenaria Rubra safety at a glance

Arenaria Rubra overall Not established Human safety data are very limited, so use cautiously and under professional guidance.

Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use to be safe.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Afatinib Dimaleate and Arenaria Rubra? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Afatinib Dimaleate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Afatinib Dimaleate is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Arenaria Rubra has documented interactions with 1 drug class — the most serious being acetylcholinesterase (ache) inhibitors (moderate) — and none of Afatinib Dimaleate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arenaria Rubra Does Interact With Other Medications

Arenaria Rubra has 17 moderate known drug interactions in our database — Afatinib Dimaleate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 17 No known interaction 2,813 (incl. Afatinib Dimaleate)

Taking anything else?

Check Another of Your Medications Against Arenaria Rubra

Covers the 2,830 medications we’ve checked against Arenaria Rubra. Pick one to open its full report.

What to actually watch for

What Afatinib Dimaleate’s Own FDA Label Lists

This is not an interaction — none of it involves Arenaria Rubra. These are the most notable effects listed in the ADVERSE REACTIONS section of Afatinib Dimaleate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Dehydration Worth acting on
Low potassium Worth acting on
Pancreatitis Worth acting on
Yellowing of the skin or eyes Worth acting on
A severe skin reaction Worth acting on
Kidney problems Worth acting on
Shortness of breath Worth acting on
Liver problems Worth acting on
Bleeding or bruising Worth acting on
A higher chance of infection Worth acting on

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Afatinib Dimaleate. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,587 voluntary FDA FAERS reports for Afatinib Dimaleate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Arenaria Rubra’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Arenaria Rubra side to compare — that is a limit of the record, not a statement that Arenaria Rubra has no side effects.

Everything else you take

See Every Supplement That Interacts With Afatinib Dimaleate

This page covers Arenaria Rubra only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Afatinib Dimaleate page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Afatinib Dimaleate page

“Afatinib (Gilotrif) is a targeted lung cancer therapy, and because its effectiveness depends on keeping a steady blood level, this list deserves genuine care. Most of the 54 supplements here either change how much of the drug the gut absorbs or interfere with P-glycoprotein, a pump that moves afatinib across cell walls, pushing its lev…”

Reviewed by 2 · Jul 18, 2026

Open the Afatinib Dimaleate interaction page

How much people look this up

Where Arenaria Rubra and Afatinib Dimaleate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arenaria Rubra

Steady interest

#855 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Afatinib Dimaleate

Top half

#1,112 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Arenaria Rubra is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arenaria Rubra reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Arenaria Rubra and Afatinib Dimaleate records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Arenaria Rubra

What is Arenaria Rubra?

Urinary and bladder complaints
Kidney stones ("stone-breaking")
Mild diuretic
Traditional digestive support
Antioxidant interest

Arenaria rubra (Spergularia rubra) is a small herb used in folk medicine, mainly for urinary and kidney complaints. Modern evidence is very limited and comes mostly from laboratory studies, so its benefits in people are not proven. Talk with a pharmacist or doctor before using it, especially if you have a medical condition or are pregnant.

Spergularia rubra · Caryophyllaceae · Above-ground parts (aerial parts) · Tea (infusion), dried herb, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Arenaria Rubra is a good idea for someone in your situation. Here is what our Arenaria Rubra record says about it on its own.

Arenaria Rubra: dosing

There is no established or standardized dose for Arenaria rubra. Reliable dosing studies in humans are lacking, so a safe and effective amount has not been defined.If you choose to use a commercial product, follow the directions on the label and do not exceed the recommended amount.

From our Arenaria Rubra monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arenaria Rubra monograph & all interactions

Medication

About Afatinib

What Is Afatinib Used For?

Brand name: Gilotrif

Gilotrif (afatinib) is used to treat metastatic non-small cell lung cancer (NSCLC) — cancer that has spread and cannot be removed by surgery. It has two specific approved uses.

First, Gilotrif is used as an initial treatment for metastatic NSCLC when the tumor carries certain EGFR mutations (gene changes in the cancer cells) confirmed by an FDA-approved test — specifically non-resistant mutations. Second, Gilotrif is used to treat metastatic squamous NSCLC (a particular cell type of lung cancer) in patients whose cancer progressed during or after platinum-based chemotherapy.

See full Afatinib drug information

Keep checking

Other Drugs & Arenaria Rubra

Browse every other medication we’ve checked against Arenaria Rubra — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

17Moderate

0Minor

2,812No known interaction

17 Moderate 2,812 No interaction

Moderate

17 interactions

No interaction 2,812 drugs checked — show the list

We also checked Arenaria Rubra against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,812 medications checked with no known interaction — see the full Arenaria Rubra list.

See the full Arenaria Rubra interactions page

See every supplement checked against Afatinib Dimaleate, ranked by severity

Evidence & sources

Arenaria Rubra References

The 2 sources that drive our Arenaria Rubra monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Arenaria Rubra is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

Using Dietary Supplements Wisely — NIH National Center for Complementary and Integrative Health Source
Herbal Medicine — MedlinePlus (NIH) Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arenaria Rubra and Afatinib Dimaleate Together: Common Questions

Is it safe to take Arenaria Rubra with Afatinib Dimaleate?

We do not list a known interaction between Arenaria Rubra and Afatinib Dimaleate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Arenaria Rubra and Afatinib Dimaleate combination checked?

Interactions in our licensed database are recorded against drug classes. Afatinib Dimaleate is filed under 2 classifications, and Arenaria Rubra has documented interactions with 1 drug class — none of Afatinib Dimaleate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Arenaria Rubra interact with any other medications?

Yes. Arenaria Rubra has 17 documented drug interactions in our database — Afatinib Dimaleate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Afatinib Dimaleate interact with any supplements?

Yes. Afatinib Dimaleate has documented interactions with 54 supplements in our database — Arenaria Rubra is not one of them. The Afatinib Dimaleate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arenaria Rubra monograph Uses, safety profile, and every drug interaction in one place Afatinib drug information The full plain-English guide to this medication Afatinib Dimaleate supplement interactions Every supplement checked against Afatinib Dimaleate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Afatinib Dimaleate and Arenaria Rubra?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.