Aristolochia - Prozac (Fluoxetine) Interaction
Herbal: Aristolochia
Also Known As: Aristolochia auricularia, Birthwort, Guan Mu Tong, Guang Fang Ji, Long Birthwort, Pelican Flower, Poison de Terre, Pomerasse, Ratelaine, Rateline, Red River Snakeroot, Sangree Root, Sangrel, Sarrasine, Serpentaire, Snakeroot, Snakeweed, Virginia Serpentary
Drug: Fluoxetine
Brand names:
Prozac, Sarafem
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Fluoxetine and Aristolochia. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Aristolochia Overview
Aristolochia is a genus of plants that includes over 500 species, many of which are known for their tubular flowers. These plants are native to a wide range of regions, including tropical and subtropical areas of the Americas, Asia, and Africa.
Aristolochia species are most commonly cultivated for their ornamental value but also have a long history of use in traditional Chinese medicine as an aphrodisiac, anticonvulsant, immune stimulant, to promote menstruation, and to treat snakebites.
However, some Aristolochia species contain aristolochic acid, a toxic compound that can cause serious health problems when ingested. The FDA (Food and Drug Administration) in the United States considers all products containing aristolochic acid to be unsafe.
Fluoxetine Overview
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Fluoxetine is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks). Fluoxetine is also used to relieve the symptoms of premenstrual dysphoric disorder, including mood swings, irritability, bloating, and breast tenderness. It is also used along with olanzapine (Zyprexa) to treat depression that did not respond to other medications and episodes of depression in people with bipolar I disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Fluoxetine is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.
Aristolochia - More Interactions
Aristolochia interacts with 350 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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