Drug & supplement interaction

Asparagus + Medroxyprogesterone

Medroxyprogesterone brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Asparagus and Medroxyprogesterone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Asparagus and Medroxyprogesterone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Medroxyprogesterone and Asparagus in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Asparagus safety at a glance

Asparagus overall Generally safe Asparagus is safe for most people when eaten as a food, but concentrated extracts are less well studied.

Pregnancy Likely Safe When used in amounts commonly found in foods. Read the full pregnancy detail

Breastfeeding Likely Safe When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of asparagus when used in medicinal amounts... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Medroxyprogesterone and Asparagus? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Medroxyprogesterone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Medroxyprogesterone is filed under 3 classifications — progestin, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Asparagus has documented interactions with 2 drug classes — the most serious being diuretic drugs (moderate) and lithium (moderate) — and none of Medroxyprogesterone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Asparagus Does Interact With Other Medications

Asparagus has 76 moderate known drug interactions in our database — Medroxyprogesterone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 76 No known interaction 2,754 (incl. Medroxyprogesterone)

Taking anything else?

Check Another of Your Medications Against Asparagus

Covers the 2,830 medications we’ve checked against Asparagus. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Asparagus and Medroxyprogesterone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

A severe allergic reaction Worth acting on Additional detail
Asparagus
“Orally and topically, asparagus can cause allergic reactions. They can occur in individuals sensitive to other members of the Liliaceae family, including onions, garlic, leeks, and chives. Ingestion of fresh or canned asparagus can cause itchy eyes, runny nose, coughing, urticaria, dysphagia, dyspnea, and anaphylaxis in sensitized people.”

Asparagus · Natural Medicines adverse-effect record, reported in asthma.
6 sources cited

15557. Volz T, Berner D, Weigert C, et al. Fixed food eruption caused by asparagus. J Allergy Clin Immunol 2005;116:1390-2. PubMed

15561. Rieker J, Ruzicka T, Neumann NJ, Homey B. Protein contact dermatitis to asparagus. J Allergy Clin Immunol 2004;113:354-5. PubMed

15562. Tabar AI, Alvarez-Puebla MJ, Gomez B, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy 2004;34:131-6. PubMed

15564. Rademaker M, Yung A. Contact dermatitis to Asparagus officinalis. Australas J Dermatol 2000;41:262-3.

32536. Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G., Gil, R. R., and Burton, G. Withanolides and related steroids. Prog.Chem.Org.Nat.Prod. 2011;94:127-229.

32594. Escribano MM, Munoz-Bellido FJ, Serrano P, et al. Acute urticaria after ingestion of asparagus. Allergy 1998;53(6):622-623. PubMed
Medroxyprogesterone

Listed in the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone. Read the label on DailyMed ›
Swelling Additional detail
Asparagus
“Orally, a specific combination product (Asparagus-P, Grunwalder) containing asparagus root 6 grams and parsley leaf 6 grams caused kidney pain and peripheral edema in approximately 15% of patients in one clinical trial. It is not clear if these effects were due to asparagus root, parsley, or the combination.”

Asparagus · Natural Medicines adverse-effect record, reported in pain.
1 source cited

94940. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
Medroxyprogesterone

Listed in the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone. Read the label on DailyMed ›
Nausea reported in 2.4% of FDA reports for Medroxyprogesterone Additional detail
Asparagus
“Orally, a specific combination product (Asparagus-P, Grunwalder) containing asparagus root 6 grams and parsley leaf 6 grams caused constipation, abdominal distension and pain, nausea, dry mouth, and gallbladder complaints in up to 50% of the study population in one clinical trial. It is not clear if these effects were due to asparagus root, parsley, or the combination.”

Asparagus · Natural Medicines adverse-effect record, reported in constipation.
1 source cited

94940. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
Medroxyprogesterone

Listed in the ADVERSE REACTIONS section of the FDA label for Medroxyprogesterone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Asparagus but not commonly for Medroxyprogesterone: bloating or gas, an allergic reaction, constipation and a stuffy or runny nose.

Effects for Medroxyprogesterone come from the ADVERSE REACTIONS section of its FDA label; effects for Asparagus come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 60,501 voluntary FDA FAERS reports for Medroxyprogesterone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Asparagus in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When used in amounts commonly found in foods.

Pregnancy Possibly Unsafe

When used in larger amounts for medicinal purposes. Asparagus extracts may have contraceptive effects; avoid using.

Lactation Likely Safe

When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of asparagus when used in medicinal amounts during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Medroxyprogesterone Is Prescribed For, and What Asparagus Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Medroxyprogesterone is a prescription medicine with approved uses on its FDA label. Asparagus is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Medroxyprogesterone is prescribed for: Medroxyprogesterone is used for different conditions depending on the product form. The injectable forms — including Depo-Provera and intramuscular medroxyprogesterone acetate injectable suspension — are used to prevent pregnancy. Depo-subQ Provera 104 (the subcutaneous injection) is also approved to manage pain associated with endometriosis. The oral tablets — sold under the brand Provera and as generic medroxyprogesterone acetate tablets — treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance.

Read the rest of what Medroxyprogesterone is prescribed for

The tablets are also used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking daily conjugated estrogens.

Asparagus has been studied for:

Cancer studied, not established Asparagus has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Asparagus for cancer

Although there is interest in using oral asparagus for cancer, there is insufficient reliable information about the clinical effects of asparagus for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Medroxyprogesterone on your own; if you are taking Asparagus for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Asparagus or Medroxyprogesterone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Asparagus or Medroxyprogesterone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Is Prometrium The Same Thing As Progesterone? Answered by Dr. Brian Staiger, PharmD · May 2023 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Medroxyprogesterone

This page covers Asparagus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Medroxyprogesterone page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 95 moderate · 41 minor.

From our pharmacist’s overview on the Medroxyprogesterone page

“Medroxyprogesterone (Provera, Depo-Provera) only works if its blood level holds steady, and 121 of the 139 supplements and herbs on file can shift that level through a single liver enzyme, CYP3A4. That makes this a list to respect, with three entries rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Medroxyprogesterone interaction page

One more smart check

Taking Asparagus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,414 real supplement products containing Asparagus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Asparagus. Even though Asparagus itself has no known interaction with Medroxyprogesterone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Asparagus and Medroxyprogesterone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Asparagus

Top 25%

#295 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Medroxyprogesterone

Steady interest

#1,509 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Asparagus reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Asparagus and Medroxyprogesterone records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Asparagus

What is Asparagus?

Mild fluid retention (diuretic)
Urinary tract support
Digestive health and fiber
General antioxidant and nutritional support
Traditional 'detox' or cleansing use

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a diuretic or for urinary health, come from traditional use and early lab studies rather than strong human research. If you are considering concentrated asparagus supplements or extracts, talk to your pharmacist or doctor first.

Asparagus officinalis · Asparagaceae · Shoots (spears), rhizome, root, and juice · Whole vegetable (food), capsules, powders, extracts, tea, and juice

An interaction check asks whether these two react with each other — it does not ask whether Asparagus is a good idea for someone in your situation. Here is what our Asparagus record says about it on its own.

Asparagus: dosing

There is no standardized or proven medicinal dose for asparagus. As a vegetable, it can be eaten freely as part of a balanced diet.For supplements, extracts, powders, or teas, follow the directions on the product label, since strengths vary widely between products.

From our Asparagus monograph — the full record covers uses, side effects and every documented interaction.

Read the full Asparagus monograph & all interactions

Medication

About Medroxyprogesterone

What Is Medroxyprogesterone Used For?

Brand names: Provera, Amen, Depo-Provera, Depo-subQ Provera 104

Medroxyprogesterone is used for different conditions depending on the product form. The injectable forms — including Depo-Provera and intramuscular medroxyprogesterone acetate injectable suspension — are used to prevent pregnancy. Depo-subQ Provera 104 (the subcutaneous injection) is also approved to manage pain associated with endometriosis.

The oral tablets — sold under the brand Provera and as generic medroxyprogesterone acetate tablets — treat secondary amenorrhea (periods that have stopped) and abnormal uterine bleeding caused by hormonal imbalance. The tablets are also used to prevent endometrial hyperplasia (abnormal thickening of the uterine lining) in postmenopausal women with a uterus who are taking daily conjugated estrogens.

Most-Reported Side Effects for Medroxyprogesterone

From FAERS, the FDA’s public side-effect reporting system (60,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Meningioma 11,278 reports

Breast cancer 10,971 reports

Breast cancer female 10,184 reports

Breast cancer metastatic 1,943 reports

Nausea 1,449 reports

See full Medroxyprogesterone drug information

Keep checking

Other Drugs & Asparagus

Browse every other medication we’ve checked against Asparagus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

76Moderate

0Minor

2,753No known interaction

76 Moderate 2,753 No interaction

Moderate

76 interactions

Showing 60 of 76 moderate interactions — see all 76 on the Asparagus page.

No interaction 2,753 drugs checked — show the list

We also checked Asparagus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,753 medications checked with no known interaction — see the full Asparagus list.

See the full Asparagus interactions page

See every supplement checked against Medroxyprogesterone, ranked by severity

Evidence & sources

Asparagus References

The 14 references that drive our Asparagus monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Volz T, Berner D, Weigert C, et al. Fixed food eruption caused by asparagus. J Allergy Clin Immunol 2005;116:1390-2. PubMed
Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids 2006;71:171-6. PubMed
Rodriguez R, Jaramillo S, Rodriguez G, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem 2005;53:5212-7. PubMed
Rieker J, Ruzicka T, Neumann NJ, Homey B. Protein contact dermatitis to asparagus. J Allergy Clin Immunol 2004;113:354-5. PubMed
Tabar AI, Alvarez-Puebla MJ, Gomez B, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy 2004;34:131-6. PubMed
Rademaker M, Yung A. Contact dermatitis to Asparagus officinalis. Australas J Dermatol 2000;41:262-3.
Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G., Gil, R. R., and Burton, G. Withanolides and related steroids. Prog.Chem.Org.Nat.Prod. 2011;94:127-229.
Hausen BM, Wolf C. 1,2,3-Trithiane-5-carboxylic acid, a first contact allergen from Asparagus officinalis (Liliaceae). Am J Contact Dermat 1996;7(1):41-46. PubMed
Escribano MM, Munoz-Bellido FJ, Serrano P, et al. Acute urticaria after ingestion of asparagus. Allergy 1998;53(6):622-623. PubMed
Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
Gaus BM, Scheiba N, Schäkel K. Asparagus-induced fixed food eruptions mimicking cutaneous lupus. Acta Derm Venereol 2014;94:731-2. PubMed
Yanagi T, Shimizu H, Shimizu T. Occupational contact dermatitis caused by asparagus. Contact Dermatitis 2010;63:54. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Asparagus and Medroxyprogesterone Together: Common Questions

Is it safe to take Asparagus with Medroxyprogesterone?

We do not list a known interaction between Asparagus and Medroxyprogesterone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Asparagus and Medroxyprogesterone have any of the same side effects?

Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Asparagus and Medroxyprogesterone used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Asparagus in each. That is a conversation for your prescriber, especially if Medroxyprogesterone is being adjusted to a target.

How was the Asparagus and Medroxyprogesterone combination checked?

Interactions in our licensed database are recorded against drug classes. Medroxyprogesterone is filed under 3 classifications, and Asparagus has documented interactions with 2 drug classes — none of Medroxyprogesterone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Asparagus interact with any other medications?

Yes. Asparagus has 76 documented drug interactions in our database — Medroxyprogesterone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Medroxyprogesterone interact with any supplements?

Yes. Medroxyprogesterone has documented interactions with 139 supplements in our database — Asparagus is not one of them. The Medroxyprogesterone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Asparagus monograph Uses, safety profile, and every drug interaction in one place Medroxyprogesterone drug information The full plain-English guide to this medication Medroxyprogesterone supplement interactions Every supplement checked against Medroxyprogesterone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Medroxyprogesterone and Asparagus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.