Drug & supplement interaction

Asparagus + Cryptenamine, Methyclothiazide

Cryptenamine, Methyclothiazide brand name: Diutensen.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Asparagus has a moderate interaction with Cryptenamine, Methyclothiazide. Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Asparagus and Cryptenamine, Methyclothiazide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIURETIC DRUGS

Why this applies to Cryptenamine, Methyclothiazide

Cryptenamine, Methyclothiazide falls under DIURETIC DRUGS — the group Asparagus interacts with.

Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus root extracts have diuretic effects. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Your Diutensen contains methyclothiazide, a water pill, plus cryptenamine to help lower blood pressure. Here's the thinking behind this one: asparagus root may have its own mild diuretic, or water-losing, effect. In theory, pairing it with a diuretic could add up, so you'd lose a little more fluid and minerals (like potassium and sodium) than you would from the medicine alone.

I want to be honest about how soft this concern is. It's only been seen in animal studies, never reported in people. Eating asparagus at dinner is not going to be a problem. The mild worry would be with concentrated asparagus extracts or supplements taken regularly. If you go that route, watch for things like dizziness, lightheadedness when standing, muscle cramps, or feeling unusually tired, and check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids 2006;71:171-6. PubMed
  2. Rodriguez R, Jaramillo S, Rodriguez G, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem 2005;53:5212-7. PubMed
  3. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Asparagus Also Interacts With Other Medications

Asparagus has 75 moderate known drug interactions in our database — the Cryptenamine, Methyclothiazide one above is one of them. If you take anything else, check it against the full list below.

Moderate 75 No known interaction 2,755 (incl. Cryptenamine, Methyclothiazide)
Taking anything else?

Check Another of Your Medications Against Asparagus

Covers the 2,830 medications we’ve checked against Asparagus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Cryptenamine, Methyclothiazide

This page covers Asparagus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cryptenamine, Methyclothiazide page lists 227 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 192 moderate · 25 minor.

From our pharmacist’s overview on the Cryptenamine, Methyclothiazide page

“Diutensen pairs two blood-pressure medicines, cryptenamine and methyclothiazide, and its supplement list calls for genuine care, starting with the ten major-rated entries among the 227 on file. The dominant pattern is additive pressure lowering, 119 ingredients that can push blood pressure down too far, plus 73 more that stack onto the…”

Reviewed by 2 · Jul 18, 2026

Open the Cryptenamine, Methyclothiazide interaction page

One more smart check

Taking Asparagus as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,414 real supplement products containing Asparagus, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Asparagus. Your product may carry other ingredients that interact with Cryptenamine, Methyclothiazide too, on top of Asparagus — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Asparagus and Cryptenamine, Methyclothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Asparagus
Top 25%

#232 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cryptenamine, Methyclothiazide
Steady interest

#1,954 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Asparagus

What is Asparagus?

Asparagus
  • Mild fluid retention (diuretic)
  • Urinary tract support
  • Digestive health and fiber
  • General antioxidant and nutritional support
  • Traditional 'detox' or cleansing use

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a diuretic or for urinary health, come from traditional use and early lab studies rather than strong human research. If you are considering concentrated asparagus supplements or extracts, talk to your pharmacist or doctor first.

Read the full Asparagus monograph & all interactions
Keep checking

Other Drugs & Asparagus

Browse every other medication we’ve checked against Asparagus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
75Moderate
0Minor
2,754No known interaction
75 Moderate 2,754 No interaction
Moderate

75 interactions

Showing 60 of 75 moderate interactions — see all 75 on the Asparagus page.

No interaction 2,754 drugs checked — show the list

We also checked Asparagus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,754 medications checked with no known interaction — see the full Asparagus list.

See the full Asparagus interactions page
See every supplement checked against Cryptenamine, Methyclothiazide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Asparagus monograph › Uses, safety, and every drug interaction in one place Cryptenamine, Methyclothiazide supplement interactions › Every supplement checked against Cryptenamine, Methyclothiazide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Asparagus and Cryptenamine, Methyclothiazide Together: Common Questions

Can you take Asparagus with Cryptenamine, Methyclothiazide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Asparagus and Cryptenamine, Methyclothiazide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cryptenamine, Methyclothiazide and Asparagus?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.