Avocado - Xifaxan (Rifaximin) Interaction
Herbal: Avocado
Also Known As: Persea americana, Abokado, Aguacate, Ahuacate, Alligator Pear, Avocat, Avocato, Beurre du Marin, Palto, Poire Alligator
Drug: Rifaximin
Brand names:
Xifaxan
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
There were no interactions found between Rifaximin and Avocado. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Avocado Overview
Avocado, produced by the avocado tree, is a fruit known for its creamy texture and thick, bumpy skin. Commonly consumed as Hass avocados in the US, these fruits weigh between 200 to 500 grams and are rich in oleic acid, akin to almonds or olive oil. Avocado oil, used in cooking, faces quality concerns such as oxidation and adulteration with soybean oil in commercial products. Nutritionally, avocados are high in protein, fiber, and monounsaturated fats, while also containing potassium, beta-sitosterol, and various phytochemicals and vitamins. Studies suggest that avocado consumption may improve cardiovascular health by enhancing endothelial function and reducing postprandial blood glucose. Additionally, avocado compounds like persenone A and B exhibit antioxidant properties with potential chemopreventive effects against inflammation-associated carcinogens.
Rifaximin Overview
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Rifaximin 200-mg tablets are used to treat traveler's diarrhea caused by certain bacteria in adults and children at least 12 years of age. Rifaximin 550-mg tablets are used to prevent episodes of hepatic encephalopathy (changes in thinking, behavior, and personality caused by a build-up of toxins in the brain in people who have liver disease) in adults who have liver disease and to treat irritable bowel syndrome (with diarrhea) in adults. Rifaximin is in a class of medications called antibiotics. Rifaximin treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Rifaximin treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease. Rifaximin will not work to treat traveler's diarrhea that is bloody or occurs with fever.
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Antibiotics such as rifaximin will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Avocado - More Interactions
Avocado interacts with 2 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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