Drug & supplement interaction

Bear's Garlic + Sirolimus

Sirolimus brand name: Rapamune.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bear's Garlic and Sirolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bear's Garlic and Sirolimus

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sirolimus and Bear's Garlic in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bear's Garlic safety at a glance

Bear's Garlic overall Use caution Generally safe as a food, but supplement-level safety is not well studied.
Pregnancy Use caution Food amounts are likely fine, but avoid concentrated supplements due to lack of safety data.
Breastfeeding Use caution Food amounts are likely fine, but supplement safety is unknown, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sirolimus and Bear's Garlic? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sirolimus

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus is filed under 5 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Bear's Garlic has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Sirolimus’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bear's Garlic Does Interact With Other Medications

Bear's Garlic has 122 moderate known drug interactions in our database — Sirolimus isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Sirolimus)
Taking anything else?

Check Another of Your Medications Against Bear's Garlic

Covers the 2,830 medications we’ve checked against Bear's Garlic. Pick one to open its full report.

What to actually watch for

What Sirolimus’s Own FDA Label Lists

This is not an interaction — none of it involves Bear's Garlic. These are the most notable effects listed in the ADVERSE REACTIONS section of Sirolimus’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • High potassium Worth acting on
  • Low potassium Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • High blood sugar Worth acting on
  • Chest pain Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Raised blood pressure Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sirolimus. Read the label on DailyMed › Bear's Garlic’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bear's Garlic side to compare — that is a limit of the record, not a statement that Bear's Garlic has no side effects.

From our Q&A

Questions About Bear's Garlic or Sirolimus

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bear's Garlic or Sirolimus, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sirolimus

This page covers Bear's Garlic only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 149 moderate · 36 minor.

From our pharmacist’s overview on the Sirolimus page

“Sirolimus (Rapamune) is the anti-rejection medicine transplant patients depend on, and it is a narrow-therapeutic-index drug, meaning small shifts in its blood level can invite rejection on one side or toxicity on the other. That is why the 188 supplements on this page deserve genuine wariness, starting with the three rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus interaction page

How much people look this up

Where Bear's Garlic and Sirolimus Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bear's Garlic
Steady interest

#1,047 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus
Top half

#1,363 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bear's Garlic reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bear's Garlic and Sirolimus records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bear's Garlic

What is Bear's Garlic?

Bear's Garlic
  • Seasoning and culinary flavoring
  • Heart and blood vessel health
  • Blood pressure support
  • Digestive complaints
  • General 'cleansing' or detox traditions

Bear's garlic is a wild relative of garlic enjoyed mainly as a mild-tasting food. Some early laboratory studies hint at heart and blood vessel benefits, but solid human evidence is lacking, so it should be viewed as a flavorful food rather than a proven remedy. As food it is generally well tolerated, but supplements or large amounts have not been well studied for safety.

Allium ursinum · Amaryllidaceae · Leaves and bulb · Fresh leaves, dried herb, tinctures, capsules, juice, teas, culinary pesto

An interaction check asks whether these two react with each other — it does not ask whether Bear's Garlic is a good idea for someone in your situation. Here is what our Bear's Garlic record says about it on its own.

Bear's Garlic: dosing

There is no established standardized dose for bear's garlic. As a food, people use the fresh leaves in cooking to taste during its spring season.For supplement forms such as capsules or tinctures, there is no proven medicinal dose.

From our Bear's Garlic monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bear's Garlic monograph & all interactions
Medication

About Sirolimus

What Is Sirolimus Used For?

Brand name: Rapamune

Sirolimus oral solution and tablets are used to help prevent organ rejection in kidney (renal) transplant patients aged 13 and older. They are also used to treat lymphangioleiomyomatosis (LAM) — a rare lung disease in which abnormal muscle-like cells invade lung tissue.

Fyarro (sirolimus, intravenous injection) is used to treat adults with locally advanced, unresectable, or metastatic malignant PEComa — a rare tumor that grows in soft tissue or organs. Hyftor (sirolimus topical gel) is used to treat facial angiofibroma (small benign skin growths on the face) associated with tuberous sclerosis in adults and children aged 6 and older.

Most-Reported Side Effects for Sirolimus

From FAERS, the FDA’s public side-effect reporting system (13,394 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fever 525 reports
Diarrhea 515 reports
Pneumonia 487 reports
Acute kidney injury 435 reports
Thrombotic microangiopathy 376 reports
See full Sirolimus drug information
Keep checking

Other Drugs & Bear's Garlic

Browse every other medication we’ve checked against Bear's Garlic — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Bear's Garlic page.

No interaction 2,707 drugs checked — show the list

We also checked Bear's Garlic against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Bear's Garlic list.

See the full Bear's Garlic interactions page
See every supplement checked against Sirolimus, ranked by severity
Evidence & sources

Bear's Garlic References

The 3 references that drive our Bear's Garlic monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Carotenuto A, De Feo V, Fattorusso E, et al. The flavonoids of Allium ursinum. Phytochem 1996;41:531-6. PubMed
  2. Bobak M, Skodova Z, Marmot M. Beer and obesity: a cross-sectional study. Eur J Clin Nutr 2003;57:1250-53. PubMed
  3. Koh-Banerjee P, Chu N, Spiegelman D, et al. Prospective study of the association of changes in dietary intake, physicial activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. Am J Clin Nutr 2003;78:719-27..

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bear's Garlic and Sirolimus Together: Common Questions

Is it safe to take Bear's Garlic with Sirolimus?
We do not list a known interaction between Bear's Garlic and Sirolimus. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bear's Garlic and Sirolimus combination checked?
Interactions in our licensed database are recorded against drug classes. Sirolimus is filed under 5 classifications, and Bear's Garlic has documented interactions with 1 drug class — none of Sirolimus's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bear's Garlic interact with any other medications?
Yes. Bear's Garlic has 122 documented drug interactions in our database — Sirolimus is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sirolimus interact with any supplements?
Yes. Sirolimus has documented interactions with 188 supplements in our database — Bear's Garlic is not one of them. The Sirolimus interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bear's Garlic monograph Uses, safety profile, and every drug interaction in one place Sirolimus drug information The full plain-English guide to this medication Sirolimus supplement interactions Every supplement checked against Sirolimus, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sirolimus and Bear's Garlic?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.