Bilberry - Acetaminophen, Codeine, Doxylamine Interaction
Herbal: Bilberry
Also Known As: Vaccinium myrtillus, Airelle, Arándano, Bilberry Fruit, Bilberry Leaf, Black Whortles, Bleaberry, Brimbelle, Burren Myrtle, Dwarf Bilberry, Dyeberry, European Bilberry, Feuille de Myrtille, Fruit de Myrtille, Gueule Noire, Huckleberry, Hurtleberry, Mauret, Myrtille
Drug: Acetaminophen, Codeine, Doxylamine
Brand names:
Mersyndol
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Acetaminophen, Codeine, Doxylamine is classified as belonging to the following category: Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90.
Bilberry Overview
Bilberry is a small, perennial shrub that belongs to the Ericaceae family and is native to Europe, the northern United States, and Canada. It is known for its small, dark purple berries, which are similar in appearance to blueberries. The name bilberry is derived from the Danish word 'bollebar', meaning "dark berry". Bilberry is high in antioxidants, including flavonoids, and are a good source of vitamins and minerals, including vitamin C, vitamin E, and manganese. Bilberry has a long history of use in traditional medicine and is claimed to have a number of potential health benefits, including improving vision, reducing inflammation, and treating diarrhea.
Bilberry - More Interactions
Bilberry interacts with 272 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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