Drug & supplement interaction

Bitter Yam + Cyclophosphamide

Cyclophosphamide brand names: Cytoxan, Neosar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bitter Yam and Cyclophosphamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bitter Yam and Cyclophosphamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cyclophosphamide and Bitter Yam in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bitter Yam safety at a glance

Bitter Yam overall Use caution Human safety data are limited, and improperly prepared bitter yam can be toxic.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cyclophosphamide and Bitter Yam? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cyclophosphamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cyclophosphamide is filed under 8 classifications — including alkylating agents, antineoplastics, cytochrome p450 2c19 (cyp2c19) substrates. Bitter Yam has documented interactions with 1 drug class — the most serious being digoxin (lanoxin) (moderate) — and none of Cyclophosphamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bitter Yam Does Interact With Other Medications

Bitter Yam has 1 moderate known drug interaction in our database — Cyclophosphamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Cyclophosphamide)
Taking anything else?

Check Another of Your Medications Against Bitter Yam

Covers the 2,830 medications we’ve checked against Bitter Yam. Pick one to open its full report.

What to actually watch for

What Cyclophosphamide’s Own FDA Label Lists

This is not an interaction — none of it involves Bitter Yam. These are the most notable effects listed in the ADVERSE REACTIONS section of Cyclophosphamide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A low white blood cell count Worth acting on mentioned in 14.3% of FDA reports for Cyclophosphamide
  • Hearing loss Worth acting on
  • Severe muscle breakdown Worth acting on
  • Low sodium Worth acting on
  • Low blood sugar Worth acting on
  • A slow heartbeat Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on

Showing the 10 most notable of 56 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Cyclophosphamide. Read the label on DailyMed › Where a percentage is shown, it is the share of 176,005 voluntary FDA FAERS reports for Cyclophosphamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Bitter Yam’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bitter Yam side to compare — that is a limit of the record, not a statement that Bitter Yam has no side effects.

Everything else you take

See Every Supplement That Interacts With Cyclophosphamide

This page covers Bitter Yam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cyclophosphamide page lists 220 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 176 moderate · 38 minor.

Open the Cyclophosphamide interaction page

How much people look this up

Where Bitter Yam and Cyclophosphamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bitter Yam
Steady interest

#855 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cyclophosphamide
Steady interest

#1,895 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bitter Yam reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bitter Yam and Cyclophosphamide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bitter Yam

What is Bitter Yam?

Bitter Yam
  • Blood sugar support
  • Digestive complaints
  • Traditional food source
  • Wound and skin care (folk use)

Bitter yam is a wild African yam used traditionally as both food and folk medicine, often for blood sugar and digestion. Scientific evidence in humans is very limited, and some bitter yam species can be toxic if not properly prepared. Talk to a pharmacist or doctor before using it as a supplement.

Dioscorea dumetorum · Dioscoreaceae · Tuber (root) · Cooked tuber, dried powder, traditional preparations

An interaction check asks whether these two react with each other — it does not ask whether Bitter Yam is a good idea for someone in your situation. Here is what our Bitter Yam record says about it on its own.

Bitter Yam: dosing

There is no established, standardized dose of bitter yam as a supplement. Traditional use varies widely and depends on how the tuber is prepared.If you choose to use a commercial product, follow the directions on the label and do not take more than recommended.

From our Bitter Yam monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bitter Yam monograph & all interactions
Medication

About Cyclophosphamide

What Is Cyclophosphamide Used For?

Brand names: Cytoxan, Neosar

Cyclophosphamide is used to treat many types of cancer in adults and children, including malignant lymphomas (such as Hodgkin's disease and Burkitt's lymphoma), multiple myeloma, several forms of leukemia, breast cancer, ovarian cancer, neuroblastoma, retinoblastoma, and advanced mycosis fungoides (a type of skin lymphoma). It is often given alongside other chemotherapy drugs rather than on its own.

Oral and injectable powder formulations (but not the Cyclophosphamide Injection solution concentrate) are also approved for minimal change nephrotic syndrome — a kidney condition — in children who have not responded well to, or cannot tolerate, steroid therapy. The injectable solution concentrate is approved for adult patients only due to its alcohol content, and is not approved for use in children.

Most-Reported Side Effects for Cyclophosphamide

From FAERS, the FDA’s public side-effect reporting system (176,005 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Febrile neutropenia 14,532 reports
Neutropenia 10,580 reports
Fever 9,242 reports
Disease progression 8,093 reports
Pneumonia 6,669 reports
See full Cyclophosphamide drug information
Keep checking

Other Drugs & Bitter Yam

Browse every other medication we’ve checked against Bitter Yam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Bitter Yam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Bitter Yam list.

See the full Bitter Yam interactions page
See every supplement checked against Cyclophosphamide, ranked by severity
Evidence & sources

Bitter Yam References

The 1 references that drive our Bitter Yam monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Nimenibo-Uadia R. Control of hyperlipidaemia, hypercholesterolaemia and hyperketonaemia by aqueous extract of Dioscorea dumetorum tuber. Trop J Pharm Res 2003;2:183-9. Available at: http://www.bioline.org.br/request?pr03009. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bitter Yam and Cyclophosphamide Together: Common Questions

Is it safe to take Bitter Yam with Cyclophosphamide?
We do not list a known interaction between Bitter Yam and Cyclophosphamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bitter Yam and Cyclophosphamide combination checked?
Interactions in our licensed database are recorded against drug classes. Cyclophosphamide is filed under 8 classifications, and Bitter Yam has documented interactions with 1 drug class — none of Cyclophosphamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bitter Yam interact with any other medications?
Yes. Bitter Yam has 1 documented drug interaction in our database — Cyclophosphamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cyclophosphamide interact with any supplements?
Yes. Cyclophosphamide has documented interactions with 220 supplements in our database — Bitter Yam is not one of them. The Cyclophosphamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bitter Yam monograph Uses, safety profile, and every drug interaction in one place Cyclophosphamide drug information The full plain-English guide to this medication Cyclophosphamide supplement interactions Every supplement checked against Cyclophosphamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cyclophosphamide and Bitter Yam?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.