Black Nightshade + Interferon Alfa-2b
Interferon Alfa-2b brand names: Rebetron, Intron A, Viraferon.
We found no known interaction between Black Nightshade and Interferon Alfa-2b in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Black Nightshade and Interferon Alfa-2b
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Interferon Alfa-2b and Black Nightshade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Black Nightshade at all — not against Interferon Alfa-2b, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Black Nightshade safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Black Nightshade in Pregnancy & Breastfeeding
When used orally because of concerns it could be teratogenic; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Interferon Alfa-2b Is Prescribed For, and What Black Nightshade Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Interferon Alfa-2b is a prescription medicine with approved uses on its FDA label. Black Nightshade is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Black Nightshade has been studied for:
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Cirrhosis studied, not established Black Nightshade has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Black Nightshade for cirrhosis
Although there is interest in using oral black nightshade for cirrhosis, there is insufficient reliable information about the clinical effects of black nightshade for this condition.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Interferon Alfa-2b on your own; if you are taking Black Nightshade for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Interferon Alfa-2b
This page covers Black Nightshade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Interferon Alfa-2b page lists 57 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Beer (major), Siberian Cocklebur (major), Wine (major), Alfalfa (moderate) and Angelica Archangelica (moderate).
By severity: 3 major · 53 moderate · 1 minor.
From our pharmacist’s overview on the Interferon Alfa-2b page
“People taking interferon alfa-2b (Intron A, Rebetron) are usually treating hepatitis or a cancer, so the liver may already be under strain, and that is exactly where most of this list points. Of the 57 supplements on file, 38 can add to liver stress, and all three major-rated interactions sit in that group: Siberian cocklebur, which ha…”
Reviewed by 2 · Jul 18, 2026
Taking Black Nightshade as Part of a Dietary Supplement Product? Check It for Interactions
We hold 37 real supplement products containing Black Nightshade, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Nightshade. Even though Black Nightshade itself has no known interaction with Interferon Alfa-2b, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Black Nightshade and Interferon Alfa-2b Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,051 of 1,452 supplements looked up here in the last 7 days
#1,694 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Nightshade reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Black Nightshade and Interferon Alfa-2b records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Black Nightshade
What is Black Nightshade?
- Digestive complaints
- Skin conditions
- Inflammation
- Fever
- Liver support (traditional)
Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health benefit is very limited, and the risk of toxicity is real. Do not use it as a supplement without medical guidance, and avoid it during pregnancy and breastfeeding.
Solanum nigrum · Solanaceae · Leaves, berries (ripe), and whole plant · Cooked leafy greens, fruit, traditional decoctions, dried herb, extracts
An interaction check asks whether these two react with each other — it does not ask whether Black Nightshade is a good idea for someone in your situation. Here is what our Black Nightshade record says about it on its own.
Black Nightshade: dosing
There is no established or standardized safe dose of black nightshade as a supplement. When it comes to wild plants, never guess at an amount or forage your own to use as medicine.
From our Black Nightshade monograph — the full record covers uses, side effects and every documented interaction.
About Interferon Alfa-2b Injection
What Is Interferon Alfa-2b Injection Used For?
Brand names: Rebetron, Intron A, Viraferon
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Interferon alfa-2b injection is used to treat a number of conditions.
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Interferon alfa-2b injection is used
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alone or in combination with ribavirin (Copegus, Rebetol, Ribasphere) to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage,
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to treat chronic hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage,
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to treat hairy cell leukemia (a white blood cell cancer),
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to treat genital warts,
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to treat Kaposi's sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS),
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to treat malignant melanoma (a cancer that begins in certain skin cells) in certain people who have had surgery to remove the cancer,
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along with another medication to treat follicular non-Hodgkin's lymphoma (NHL; a slow-growing blood cancer).
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Interferon alfa-2b is in a class of medications called immunomodulators. Interferon alfa-2b works to treat hepatitis C virus (HCV) and hepatitis B virus (HBV) by decreasing the amount virus in the body. Interferon alfa-2b may not cure hepatitis B or hepatitis C or prevent you from developing complications from these infections such as cirrhosis (scarring) of the liver, liver failure, or liver cancer. It also may not prevent the spread of hepatitis B or C to other people. It is not known exactly how interferon alfa-2b works to treat cancer or genital warts.
Other Drugs & Black Nightshade
Browse every other medication we’ve checked against Black Nightshade — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Black Nightshade against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Nightshade list.
Black Nightshade References
The 1 references that drive our Black Nightshade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Black Nightshade and Interferon Alfa-2b Together: Common Questions
Is it safe to take Black Nightshade with Interferon Alfa-2b?
Are Black Nightshade and Interferon Alfa-2b used for the same thing?
Does Interferon Alfa-2b interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.