Drug & supplement interaction

Bog Bilberry + diphenhydramine, calamine

diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Bog Bilberry and diphenhydramine, calamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bog Bilberry and diphenhydramine, calamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between diphenhydramine, calamine and Bog Bilberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Bog Bilberry at all — not against diphenhydramine, calamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bog Bilberry safety at a glance

Bog Bilberry overall Use caution Generally safe as a food, but supplement safety is not well studied.
Pregnancy Possibly Safe When the fruit is used orally in food amounts. Read the full pregnancy detail
Breastfeeding Possibly Safe When the fruit is used orally in food amounts. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining diphenhydramine, calamine and Bog Bilberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Bog Bilberry Itself Has Been Linked To

This is not an interaction — nothing below involves diphenhydramine, calamine. It is the side-effect record for Bog Bilberry on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bog Bilberry, this list is the first place to look.

  • Vomiting / Nausea Additional detail

    “Orally, poisonings from the ingestion of large quantities of the bog bilberry fruit are rare and were thought to be due to contamination with a fungus, Sclerroyina megalospora, that sometimes grows on bog bilberry (18). The symptoms of poisoning include queasiness and vomiting (18).”

    Bog Bilberry · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Bog Bilberry — expand a row for the licensed statement it rests on. We haven’t matched diphenhydramine, calamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for diphenhydramine, calamine.

Special populations

Bog Bilberry in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When the fruit is used orally in food amounts.

Pregnancy And Lactation Possibly Unsafe

When fungus-infested plants are used orally in large amounts; avoid using. There is insufficient reliable information available about the safety of bog bilberry when used orally in medicinal amounts.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With diphenhydramine, calamine

This page covers Bog Bilberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the diphenhydramine, calamine page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the diphenhydramine, calamine page

“Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb.”

Reviewed by 2 · Jul 18, 2026

Open the diphenhydramine, calamine interaction page

One more smart check

Taking Bog Bilberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 75 real supplement products containing Bog Bilberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bog Bilberry. Even though Bog Bilberry itself has no known interaction with diphenhydramine, calamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bog Bilberry and diphenhydramine, calamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bog Bilberry
Steady interest

#1,361 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication diphenhydramine, calamine
Top half

#796 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bog Bilberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bog Bilberry and diphenhydramine, calamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bog Bilberry

What is Bog Bilberry?

  • Antioxidant support
  • Eye and vision health
  • Circulation and blood vessel health
  • General wellness
  • Anti-inflammatory support

Bog bilberry is a wild blueberry-relative rich in antioxidant pigments called anthocyanins, and people use it much like its better-known cousin, the European bilberry. As a food it is generally safe, but there is little high-quality human research showing it treats any specific health condition. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy or breastfeeding.

Vaccinium uliginosum · Ericaceae · Berries (fruit); sometimes leaves · Fresh or dried berries, juice, jams, extracts, capsules, teas

An interaction check asks whether these two react with each other — it does not ask whether Bog Bilberry is a good idea for someone in your situation. Here is what our Bog Bilberry record says about it on its own.

Bog Bilberry: dosing

There is no established standard dose for bog bilberry as a supplement. As a food, you can simply enjoy the berries the way you would blueberries.If you choose a supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Bog Bilberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bog Bilberry monograph & all interactions
Keep checking

Other Drugs & Bog Bilberry

Browse every other medication we’ve checked against Bog Bilberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Bog Bilberry References

The 2 references that drive our Bog Bilberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Zu XY, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li J. Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells. Chin Med J (Engl). 2010;123(19):2714-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bog Bilberry and diphenhydramine, calamine Together: Common Questions

Is it safe to take Bog Bilberry with diphenhydramine, calamine?
We do not list a known interaction between Bog Bilberry and diphenhydramine, calamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does diphenhydramine, calamine interact with any supplements?
Yes. diphenhydramine, calamine has documented interactions with 6 supplements in our database — Bog Bilberry is not one of them. The diphenhydramine, calamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About diphenhydramine, calamine and Bog Bilberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.