Medication interaction hub

What Supplements Interact with diphenhydramine, calamine?

diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion. Every interaction below applies to the brands too.

6 Interactions 5 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with diphenhydramine, calamine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check diphenhydramine, calamine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb. None of the six ingredients on file rates major (five moderate, one minor), so for most people this is a workable list; what matters is knowing which pairings to watch.

The six split evenly into two stories. Fever bark and iboga share the yohimbe problem, since their active compounds also rely on CYP2D6. The other three involve the skin itself. DMSO may pull more medicine through than intended, and turpentine oil might do the same, changing how a product meant to act on the surface behaves. Keep these off the same patch of skin as Caladryl, and mention regular use to your pharmacist.

— , Clinical Pharmacist · July 18, 2026

Moderate 5 Minor 1 No known interaction 1,446

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

diphenhydramine, calamine: Top Interactions at a Glance

The most significant diphenhydramine, calamine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 6 highest-ranked of 6 interacting ingredients — plus 1,446 more checked with no known interaction. See the complete ranked list.

Start here

The Moderate Interactions to Know About

The most clinically significant diphenhydramine, calamine + supplement combinations in our database, best-documented first. Open any card for the full report.

Moderate Likelihood Probable Yohimbe + diphenhydramine, calaminei

CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Read the full interaction Moderate Likelihood Possible Dimethylsulfoxide (dmso) + diphenhydramine, calaminei

Topical DMSO might increase the effects and adverse effects of topical drugs.

Read the full interaction Moderate Likelihood Possible Fever Bark + diphenhydramine, calaminei

Theoretically, CYP2D6 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Read the full interaction Moderate Likelihood Possible Iboga + diphenhydramine, calaminei

Theoretically, taking iboga with CYP2D6 inhibitors might increase the levels and clinical effects of ibogaine.

Read the full interaction Moderate Likelihood Possible Turpentine Oil + diphenhydramine, calaminei

Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine or haloperidol when...

Read the full interaction
The complete list

Every Supplement Checked Against diphenhydramine, calamine

All 1,452 ingredients in our database, ranked by severity — 6 with a diphenhydramine, calamine interaction on file and 1,446 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With diphenhydramine, calamine?

One-line answers, one card per combination — scroll through today’s 8 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Turpentine Oil with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + diphenhydramine, calamine answer

Can you take Iboga with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with CYP2D6 inhibitors might increase the levels and clinical effects of ibogaine.

Full Iboga + diphenhydramine, calamine answer

Can you take Alchemilla with diphenhydramine, calamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + diphenhydramine, calamine answer

Can you take Yohimbe with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.

Full Yohimbe + diphenhydramine, calamine answer

Can you take Dimethylsulfoxide (dmso) with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Topical DMSO might increase the effects and adverse effects of topical drugs.

Full Dimethylsulfoxide (dmso) + diphenhydramine, calamine answer

Can you take Fever Bark with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP2D6 inhibitors might increase the levels and clinical effects of yohimbine, a constituent of fever bark.

Full Fever Bark + diphenhydramine, calamine answer

Can you take Iboga with diphenhydramine, calamine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking iboga with CYP2D6 inhibitors might increase the levels and clinical effects of ibogaine.

Full Iboga + diphenhydramine, calamine answer

Can you take Alchemilla with diphenhydramine, calamine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. While no side effects have been reported from orally using Alchemilla, a clinical study titled "Treatment of Aphthous Stomatitis with Topica...

Full Alchemilla + diphenhydramine, calamine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) diphenhydramine, calamine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by diphenhydramine, calamine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

diphenhydramine, calamine sits in 2 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach diphenhydramine, calamine through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach diphenhydramine, calamine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against diphenhydramine, calamine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against diphenhydramine, calamine.

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Products that contain diphenhydramine, calamine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with diphenhydramine, calamine.

Yohimbe by FINAFLEX contains Yohimbe Xcelerate Watermelon Berry by Beneve contains Yohimbe Ultra Pump Fuel v.5 Insanity Tropical Orange Mango by PMD contains Yohimbe Yohimbe 500 mg by Eurovital Nutraceuticals contains Yohimbe
Pharmacist Counseling Corner

diphenhydramine, calamine & Supplements: Common Questions

What supplements interact with diphenhydramine, calamine?
Our database currently documents 6 ingredients with a known diphenhydramine, calamine interaction (0 major, 5 moderate, 1 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 6. The highest-ranked right now: Yohimbe, Dimethylsulfoxide (dmso), Fever Bark.
Which diphenhydramine, calamine supplement interactions are the most serious?
None of the diphenhydramine, calamine supplement interactions on file are currently rated major. The most significant are the 5 moderate-rated ones — combinations that may need monitoring, a dose adjustment, or separated timing. Still worth a quick look through the ranked list for anything you take daily. Jump to the ranked list.
Can I take vitamins or supplements while on diphenhydramine, calamine?
Plenty of supplements coexist fine with diphenhydramine, calamine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Caladryl cream have the same supplement interactions as diphenhydramine, calamine?
Yes — Caladryl cream, Caladryl lotion all contain diphenhydramine, calamine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about diphenhydramine, calamine and my other medications?
This page covers diphenhydramine, calamine against supplements and herbal ingredients. Checking diphenhydramine, calamine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.