Winter Savory + diphenhydramine, calamine
diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion.
We found no known interaction between Winter Savory and diphenhydramine, calamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Winter Savory and diphenhydramine, calamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between diphenhydramine, calamine and Winter Savory in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Winter Savory safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for diphenhydramine, calamine
Interactions in our licensed database are recorded against drug classes, not just single drug names. diphenhydramine, calamine is filed under 2 classifications — cytochrome p450 2d6 (cyp2d6) inhibitors, topical drugs. Winter Savory has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of diphenhydramine, calamine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Winter Savory Does Interact With Other Medications
Winter Savory has 1 moderate known drug interaction in our database — diphenhydramine, calamine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Winter Savory
We haven’t checked that one against Winter Savory yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Winter Savory. Pick one to open its full report.
See Every Supplement That Interacts With diphenhydramine, calamine
This page covers Winter Savory only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the diphenhydramine, calamine page lists 6 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).
By severity: 5 moderate · 1 minor.
From our pharmacist’s overview on the diphenhydramine, calamine page
“Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb.”
Reviewed by 2 · Jul 18, 2026
Taking Winter Savory as Part of a Dietary Supplement Product? Check It for Interactions
We hold 8 real supplement products containing Winter Savory, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Winter Savory. Even though Winter Savory itself has no known interaction with diphenhydramine, calamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Winter Savory and diphenhydramine, calamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,164 of 1,452 supplements looked up here in the last 7 days
#442 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Winter Savory reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Winter Savory and diphenhydramine, calamine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Winter Savory
What is Winter Savory?
- Digestive upset and gas
- Sore throat
- Antimicrobial
- Cough
- Seasoning food
Winter savory is a culinary herb in the mint family used mainly to flavor food and, in folk medicine, to ease digestion and sore throats. Solid human research is very limited, so it should not be relied on to treat any health condition. It is generally considered safe in food amounts, but concentrated extracts and the essential oil call for more caution.
Satureja montana · Lamiaceae · Leaves, flowering tops, and essential oil · Culinary herb, tea, dried herb, capsules, essential oil
An interaction check asks whether these two react with each other — it does not ask whether Winter Savory is a good idea for someone in your situation. Here is what our Winter Savory record says about it on its own.
Winter Savory: dosing
There is no established, standardized medicinal dose for winter savory. Most people simply use it as a seasoning in cooking, which is considered the safest way to enjoy it.If you choose a tea, capsule, or essential oil product, follow the directions on the product label and do not exceed the suggested amount. Essential oils are very concentrated and require special handling and dilution.
From our Winter Savory monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Winter Savory
Browse every other medication we’ve checked against Winter Savory — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Winter Savory against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Abemaciclib ›
- Hydroxyurea ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Warfarin Sodium ›
- Tirzepatide ›
- Prednisone ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Acyclovir ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Acetaminophen, Codeine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Dextroamphetamine ›
- Azithromycin ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Methylene Blue ›
- Quetiapine ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Naproxen ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Winter Savory list.
Winter Savory References
The 3 references that drive our Winter Savory monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Sansalone S, Russo GI, Mondaini N, Cantiello F, Antonini G, Cai T. A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation. Arch Ital PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Winter Savory and diphenhydramine, calamine Together: Common Questions
Is it safe to take Winter Savory with diphenhydramine, calamine?
How was the Winter Savory and diphenhydramine, calamine combination checked?
Does Winter Savory interact with any other medications?
Does diphenhydramine, calamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.