Methyldiazinol + diphenhydramine, calamine
diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion.
We found no known interaction between Methyldiazinol and diphenhydramine, calamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Methyldiazinol and diphenhydramine, calamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between diphenhydramine, calamine and Methyldiazinol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Methyldiazinol at all — not against diphenhydramine, calamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Methyldiazinol safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Methyldiazinol in Pregnancy & Breastfeeding
When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With diphenhydramine, calamine
This page covers Methyldiazinol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the diphenhydramine, calamine page lists 6 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).
By severity: 5 moderate · 1 minor.
From our pharmacist’s overview on the diphenhydramine, calamine page
“Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb.”
Reviewed by 2 · Jul 18, 2026
Where Methyldiazinol and diphenhydramine, calamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#990 of 1,452 supplements looked up here in the last 7 days
#803 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methyldiazinol reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Methyldiazinol and diphenhydramine, calamine records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Methyldiazinol
What is Methyldiazinol?
There is no reliable scientific or pharmaceutical information about a substance called "Methyldiazinol." It does not appear to be a recognized herb, dietary supplement, or well-documented compound, so we cannot confirm what it is, whether it works, or whether it is safe. Do not take any product marketed under this name without first verifying its identity and contents with a pharmacist or doctor.
An interaction check asks whether these two react with each other — it does not ask whether Methyldiazinol is a good idea for someone in your situation. Here is what our Methyldiazinol record says about it on its own.
Methyldiazinol: dosing
There is no established or safe dose for Methyldiazinol because the substance is not recognized or studied.We cannot recommend any amount. If a product label gives a dose, that does not mean it has been tested for safety.
From our Methyldiazinol monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Methyldiazinol
Browse every other medication we’ve checked against Methyldiazinol — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Methyldiazinol against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Clopidogrel ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Letrozole ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methyldiazinol list.
Methyldiazinol References
The 1 references that drive our Methyldiazinol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Methyldiazinol and diphenhydramine, calamine Together: Common Questions
Is it safe to take Methyldiazinol with diphenhydramine, calamine?
Does diphenhydramine, calamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.