Drug & supplement interaction

Red Soapwort + diphenhydramine, calamine

diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Red Soapwort and diphenhydramine, calamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Red Soapwort and diphenhydramine, calamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between diphenhydramine, calamine and Red Soapwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Red Soapwort at all — not against diphenhydramine, calamine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Soapwort safety at a glance

Red Soapwort overall Use caution Its saponins can irritate the digestive tract and may be toxic in larger amounts, so internal use should be approached carefully.
Pregnancy Avoid Not enough safety data exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining diphenhydramine, calamine and Red Soapwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Red Soapwort Itself Has Been Linked To

This is not an interaction — nothing below involves diphenhydramine, calamine. It is the side-effect record for Red Soapwort on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Red Soapwort, this list is the first place to look.

  • Stomach upset / Vomiting / Nausea Additional detail

    “Orally, red soapwort has been reported to cause stomach irritation (2), nausea, and vomiting (7).”

    Red Soapwort · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 7. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.

Everything above comes from the Natural Medicines adverse-effect record for Red Soapwort — expand a row for the licensed statement it rests on. We haven’t matched diphenhydramine, calamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for diphenhydramine, calamine.

Everything else you take

See Every Supplement That Interacts With diphenhydramine, calamine

This page covers Red Soapwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the diphenhydramine, calamine page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the diphenhydramine, calamine page

“Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb.”

Reviewed by 2 · Jul 18, 2026

Open the diphenhydramine, calamine interaction page

One more smart check

Taking Red Soapwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 31 real supplement products containing Red Soapwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Soapwort. Even though Red Soapwort itself has no known interaction with diphenhydramine, calamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Soapwort and diphenhydramine, calamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Soapwort
Steady interest

#935 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication diphenhydramine, calamine
Top 25%

#418 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Soapwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red Soapwort and diphenhydramine, calamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Soapwort

What is Red Soapwort?

  • Natural soap and shampoo making
  • Cough and chest congestion (traditional)
  • Skin conditions like eczema and itching (topical, traditional)
  • Mild inflammation (traditional)
  • Digestive complaints (traditional)

Red soapwort (Saponaria officinalis) is a soap-making plant that has been used in folk medicine as a cough remedy and skin wash. There is very little reliable human research to support any health claim, and its saponins can irritate the gut and even be toxic if too much is swallowed, so it is mainly used externally or as a natural cleanser. Talk with a pharmacist or doctor before using it medicinally.

Saponaria officinalis · Caryophyllaceae · Root and aerial parts (leaves and stems) · Dried root, tea/decoction, liquid extract, topical washes, and as a natural cleanser in soaps and shampoos

An interaction check asks whether these two react with each other — it does not ask whether Red Soapwort is a good idea for someone in your situation. Here is what our Red Soapwort record says about it on its own.

Red Soapwort: dosing

There is no well-established or standardized medicinal dose for red soapwort. Because of its saponin content and the risk of digestive irritation or toxicity, there is no safe "recommended" amount for internal use that has been confirmed by good research.If you use a commercial product (such as a soapwort-based soap, shampoo, or labeled supplement), follow the directions on the package.

From our Red Soapwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Soapwort monograph & all interactions
Keep checking

Other Drugs & Red Soapwort

Browse every other medication we’ve checked against Red Soapwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Red Soapwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Red Soapwort list.

See the full Red Soapwort interactions page
See every supplement checked against diphenhydramine, calamine, ranked by severity
Evidence & sources

Red Soapwort References

The 2 references that drive our Red Soapwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Soapwort and diphenhydramine, calamine Together: Common Questions

Is it safe to take Red Soapwort with diphenhydramine, calamine?
We do not list a known interaction between Red Soapwort and diphenhydramine, calamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does diphenhydramine, calamine interact with any supplements?
Yes. diphenhydramine, calamine has documented interactions with 6 supplements in our database — Red Soapwort is not one of them. The diphenhydramine, calamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Soapwort monograph Uses, safety profile, and every drug interaction in one place diphenhydramine, calamine supplement interactions Every supplement checked against diphenhydramine, calamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.