Herb & supplement monograph

Red Soapwort Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Red Soapwort

0 medications have a known interaction with Red Soapwort, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Red Soapwort. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Red Soapwort combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Red Soapwort: Uses, Safety & Side Effects

The bottom line

Red soapwort (Saponaria officinalis) is a soap-making plant that has been used in folk medicine as a cough remedy and skin wash. There is very little reliable human research to support any health claim, and its saponins can irritate the gut and even be toxic if too much is swallowed, so it is mainly used externally or as a natural cleanser. Talk with a pharmacist or doctor before using it medicinally.

Scientific name
Saponaria officinalis
Family
Caryophyllaceae
Part used
Root and aerial parts (leaves and stems)
Common forms
Dried root, tea/decoction, liquid extract, topical washes, and as a natural cleanser in soaps and shampoos
People commonly use it for
  • Natural soap and shampoo making
  • Cough and chest congestion (traditional)
  • Skin conditions like eczema and itching (topical, traditional)
  • Mild inflammation (traditional)
  • Digestive complaints (traditional)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Its saponins can irritate the digestive tract and may be toxic in larger amounts, so internal use should be approached carefully.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Red soapwort, known scientifically as Saponaria officinalis, is a flowering plant native to Europe and parts of Asia and now found in many other places. It belongs to the carnation (pink) family. The plant is well known because its root and leaves are rich in natural compounds called saponins, which create a soapy lather when mixed with water.

Because of this property, soapwort has long been used to make gentle soaps, herbal shampoos, and cleansers, and even to clean delicate fabrics and antique textiles. In traditional folk medicine, the plant has also been taken by mouth or applied to the skin for things like coughs and skin irritation.

Today, most of soapwort's everyday use is as a natural cleansing ingredient rather than as a proven medicine.

How it works

The main active compounds in red soapwort are saponins. These natural substances foam like soap when shaken in water, which is why the plant works as a cleanser. Saponins can break down oils and dirt, and they may also affect cell membranes.

In the lab, some saponins have shown effects that researchers describe as anti-inflammatory, mucus-loosening, or able to interact with microbes. Soapwort also contains other compounds that scientists have studied for their biological activity.

It is important to know that most of this information comes from laboratory or animal research, not from well-designed human studies. The way saponins act in a test tube does not always mean they will safely or effectively do the same thing in the body.

Effectiveness

Does Red Soapwort work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Red Soapwort, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Acne
Rating & evidence shown verbatim from Natural Medicines

Oral red soapwort has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Used externally as part of a soap or shampoo, soapwort is generally considered low-risk for most people, though it may irritate the eyes or sensitive skin.

Taking soapwort by mouth is more concerning. Saponins can irritate the lining of the stomach and intestines, and in larger amounts they may be toxic. For this reason, internal use should be limited, brief, and ideally guided by a knowledgeable professional.

People who should be especially cautious or avoid it include children, older adults, and anyone with digestive problems. Pregnant and breastfeeding people should avoid soapwort because there is not enough safety information. If you have any health condition or take medication, check with a pharmacist or doctor before using soapwort medicinally.

Side effects

When taken by mouth, the most common side effects are linked to its saponin content and may include nausea, stomach upset, vomiting, and diarrhea. Larger amounts can cause stronger digestive irritation.

On the skin or in the eyes, soapwort can cause irritation, redness, or stinging in sensitive people.

Serious effects are possible if too much is swallowed. Because saponins can be toxic in high amounts, large doses should be avoided entirely. If someone swallows a large amount or has severe symptoms, seek medical help right away.

Red Soapwort: Reported Adverse Effects

Documented safety reports on Red Soapwort from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Reports by condition
Nausea and vomiting Gastrointestinal

Orally, red soapwort has been reported to cause stomach irritation, nausea, and vomiting.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established or standardized medicinal dose for red soapwort. Because of its saponin content and the risk of digestive irritation or toxicity, there is no safe "recommended" amount for internal use that has been confirmed by good research.

If you use a commercial product (such as a soapwort-based soap, shampoo, or labeled supplement), follow the directions on the package. Do not assume that "natural" means it is safe to take in large amounts.

Before using soapwort for any health reason, talk with a pharmacist or doctor, especially if you are considering taking it by mouth.

Pregnancy & Breastfeeding

Red Soapwort & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Red Soapwort & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 references that drive our Red Soapwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Red Soapwort

4 brands in our database make a supplement containing Red Soapwort.

Product directory

Supplement products with Red Soapwort

31 products in our database contain Red Soapwort. Open any to see its full ingredient list and every drug interaction we check.

Depurative Formula by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Depurative Formula 450 mg by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Depurative Formula Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Depurative Formula Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Depurative Formula Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Depurative Formula Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Depurative Formula Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Depurative Formula Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort by Herbal Terra Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort by Herbal Terra Liquid 2 Fluid Ounce(s) · 60 mL View ingredients & interactions Soapwort Alcohol Free by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions Soapwort Herb by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort Herb 450 mg by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Soapwort Herb Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort Herb Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort Herb Powder by TerraVita Premium Collection Powder 1 Ounce(s) View ingredients & interactions Soapwort Herb Powder by TerraVita Premium Collection Powder 4 Ounce(s) View ingredients & interactions Soapwort Herb Strawberry Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort Herb Vanilla Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Soapwort Non-Alcohol by Hawaii Pharm Liquid 4 Fluid Ounce(s) · 120 mL View ingredients & interactions
Pharmacist Counseling Corner

Red Soapwort: Common Questions

What is Red Soapwort used for, and does it work?
People use Red Soapwort for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Red Soapwort interact with prescription medications?
We do not currently list any known drug interactions for Red Soapwort. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Red Soapwort interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Red Soapwort with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Red Soapwort interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Red Soapwort mainly used for?
It is best known as a natural cleanser used to make soaps, shampoos, and gentle detergents. In folk medicine it has also been used for coughs and skin irritation, but there is little solid evidence that it works as a medicine.
Is Red Soapwort safe to take by mouth?
Caution is needed. Soapwort contains saponins that can irritate the stomach and intestines, and large amounts may be toxic, so internal use should be limited and guided by a professional.
Can I use Red Soapwort while pregnant or breastfeeding?
It is best to avoid it. There is not enough safety information for pregnancy or breastfeeding, so the safest choice is to skip it.
Does soapwort really clean like soap?
Yes. Its saponins create a natural lather in water, which is why it has long been used to make soaps, shampoos, and to clean delicate fabrics.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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