Drug & supplement interaction

Ostarine + diphenhydramine, calamine

diphenhydramine, calamine brand names: Caladryl cream, Caladryl lotion.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ostarine and diphenhydramine, calamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ostarine and diphenhydramine, calamine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between diphenhydramine, calamine and Ostarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ostarine safety at a glance

Ostarine overall Avoid Ostarine is an unapproved investigational drug with documented safety risks and no FDA approval.
Pregnancy Avoid It affects hormone pathways and must be avoided during pregnancy.
Breastfeeding Avoid There is no safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining diphenhydramine, calamine and Ostarine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for diphenhydramine, calamine

Interactions in our licensed database are recorded against drug classes, not just single drug names. diphenhydramine, calamine is filed under 2 classifications — cytochrome p450 2d6 (cyp2d6) inhibitors, topical drugs. Ostarine has documented interactions with 6 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate), hepatotoxic drugs (moderate) and probenecid (benemid) (moderate) — and none of diphenhydramine, calamine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ostarine Does Interact With Other Medications

Ostarine has 440 moderate, 171 minor known drug interactions in our database — diphenhydramine, calamine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 440 Minor 171 No known interaction 2,219 (incl. diphenhydramine, calamine)
Taking anything else?

Check Another of Your Medications Against Ostarine

Covers the 2,830 medications we’ve checked against Ostarine. Pick one to open its full report.

What to actually watch for

What Ostarine Itself Has Been Linked To

This is not an interaction — nothing below involves diphenhydramine, calamine. It is the side-effect record for Ostarine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ostarine, this list is the first place to look. 6 entries are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    “Orally, in a 12-week study of healthy elderly patients taking ostarine 1-3 mg daily, back pain was reported in 25% of patients. However, in a 16-week study of cancer patients taking ostarine 1-3 mg daily, back pain occurred at a similar rate with ostarine and placebo.

    In one case, a 43-year-old male taking ostarine and cardarine to increase muscle mass presented with several symptoms, including myalgia and rhabdomyol…”

    Ostarine · Natural Medicines adverse-effect record, reported in back pain.

    3 sources cited
    1. 98833. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
    2. 98832. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
    3. 111382. Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
  • A heart attack Worth acting on Additional detail

    “Orally, in a 12-week study of healthy elderly patients taking ostarine daily, high-density lipoprotein (HDL) cholesterol levels decreased by 9 mg/dL and 15 mg/dL with ostarine 1 mg and 3 mg, respectively, when compared with placebo. Theoretically, reductions in HDL reported with ostarine could potentially increase the risk for adverse cardiovascular effects. In fact, the U.S.”

    Ostarine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    5 sources cited
    1. 98833. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
    2. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    3. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    4. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
    5. 98840. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
  • Yellowing of the skin or eyes Worth acting on Additional detail

    “Orally, in a 16-week study of cancer patients taking ostarine 1-3 mg daily, a transient increase in alanine aminotransferase (ALT) of 2- to 4-times the upper limit of normal occurred in 7.4% of patients taking ostarine 3 mg.”

    Ostarine · Natural Medicines adverse-effect record, reported in anorexia.

    6 sources cited
    1. 98832. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
    2. 98833. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
    3. 94879. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
    4. 94880. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
    5. 94881. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
    6. 106197. Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
  • A low platelet count / Anemia Worth acting on Additional detail

    “Orally, in a 16-week study of cancer patients taking ostarine 1-3 mg daily, anemia and thrombocytopenia were reported more frequently with ostarine than with placebo, although the rate of occurrence in both groups was similar.”

    Ostarine · Natural Medicines adverse-effect record, reported in anemia.

    1 source cited
    1. 98832. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
  • Shortness of breath / A higher chance of infection Worth acting on Additional detail

    “Orally, in a 16-week study of cancer patients taking ostarine 1-3 mg daily, pneumonia occurred more frequently with ostarine than with placebo. Cough and dyspnea were also reported, but at rates slightly lower than placebo. In a 12-week study of healthy elderly patients taking ostarine 1-3 mg daily, cough occurred more frequently with ostarine than with placebo.”

    Ostarine · Natural Medicines adverse-effect record, reported in cancer.

    2 sources cited
    1. 98832. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
    2. 98833. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
  • Liver problems Worth acting on Additional detail

    “Orally, ostarine is possibly unsafe.

    Most Common Adverse Effects:

    Orally: Abdominal pain, anorexia, constipation, diarrhea, nausea, and transient increases in alanine aminotransferase (ALT) levels.

    Serious Adverse Effects (Rare):

    Orally: Hepatotoxicity.”

    Ostarine · Natural Medicines adverse-effect record, reported in anorexia.

  • Weight loss Additional detail

    Recorded for Ostarine in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

  • Back pain Additional detail

    Recorded for Ostarine in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

Showing the 10 most notable of 22 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Ostarine — expand a row for the licensed statement it rests on. We haven’t matched diphenhydramine, calamine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for diphenhydramine, calamine.

Everything else you take

See Every Supplement That Interacts With diphenhydramine, calamine

This page covers Ostarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the diphenhydramine, calamine page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Fever Bark (moderate), Iboga (moderate), Turpentine Oil (moderate) and Yohimbe (moderate).

By severity: 5 moderate · 1 minor.

From our pharmacist’s overview on the diphenhydramine, calamine page

“Yohimbe is the entry I would read first. Diphenhydramine, the itch-relieving antihistamine in Caladryl cream and lotion, blocks a liver enzyme called CYP2D6, and yohimbine, the active compound in yohimbe bark, needs that enzyme to leave the body, so its levels and side effects can climb.”

Reviewed by 2 · Jul 18, 2026

Open the diphenhydramine, calamine interaction page

One more smart check

Taking Ostarine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 33 real supplement products containing Ostarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ostarine. Even though Ostarine itself has no known interaction with diphenhydramine, calamine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ostarine and diphenhydramine, calamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ostarine
Steady interest

#1,173 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication diphenhydramine, calamine
Top 25%

#418 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ostarine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ostarine and diphenhydramine, calamine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ostarine

What is Ostarine?

  • Muscle building
  • Athletic performance
  • Fat loss / body recomposition
  • Bodybuilding cycles

Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by the FDA, is banned in sports, and has been linked to liver injury and other serious harms, so it is not recommended for general use.

Synthetic compound (not from a plant) · Capsules, tablets, liquids, powders sold as research chemicals or 'sports supplements'

An interaction check asks whether these two react with each other — it does not ask whether Ostarine is a good idea for someone in your situation. Here is what our Ostarine record says about it on its own.

Ostarine: dosing

There is no established safe or approved dose of Ostarine, because it is not an approved medicine or a legitimate dietary supplement. Doses used in research studies were given under medical supervision and do not apply to over-the-counter use.We do not recommend using Ostarine. Products sold online may not contain the dose listed on the label and may include other hidden substances.

From our Ostarine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ostarine monograph & all interactions
Keep checking

Other Drugs & Ostarine

Browse every other medication we’ve checked against Ostarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
440Moderate
171Minor
2,218No known interaction
440 Moderate 171 Minor 2,218 No interaction
Moderate

440 interactions

Showing 60 of 440 moderate interactions — see all 440 on the Ostarine page.

Minor

171 interactions

Showing 60 of 171 minor interactions — see all 171 on the Ostarine page.

No interaction 2,218 drugs checked — show the list

We also checked Ostarine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,218 medications checked with no known interaction — see the full Ostarine list.

See the full Ostarine interactions page
See every supplement checked against diphenhydramine, calamine, ranked by severity
Evidence & sources

Ostarine References

The 10 references that drive our Ostarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  2. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  3. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  4. Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
  5. Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
  6. Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024 (enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs 2016;34(4):458-67. PubMed
  7. FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
  8. Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
  9. Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
  10. Weinblatt D, Roy S. Drug-Induced Liver Injury Secondary to Enobosarm: A Selective Androgen Receptor Modulator. J Med Cases 2022;13(5):244-248. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ostarine and diphenhydramine, calamine Together: Common Questions

Is it safe to take Ostarine with diphenhydramine, calamine?
We do not list a known interaction between Ostarine and diphenhydramine, calamine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ostarine and diphenhydramine, calamine combination checked?
Interactions in our licensed database are recorded against drug classes. diphenhydramine, calamine is filed under 2 classifications, and Ostarine has documented interactions with 6 drug classes — none of diphenhydramine, calamine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ostarine interact with any other medications?
Yes. Ostarine has 611 documented drug interactions in our database — diphenhydramine, calamine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does diphenhydramine, calamine interact with any supplements?
Yes. diphenhydramine, calamine has documented interactions with 6 supplements in our database — Ostarine is not one of them. The diphenhydramine, calamine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ostarine monograph Uses, safety profile, and every drug interaction in one place diphenhydramine, calamine supplement interactions Every supplement checked against diphenhydramine, calamine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About diphenhydramine, calamine and Ostarine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.