Ostarine + Buspirone
Buspirone brand name: BuSpar.
We found no known interaction between Ostarine and Buspirone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Ostarine and Buspirone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Buspirone and Ostarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ostarine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Buspirone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Buspirone is filed under 5 classifications — including serotonergic drugs, serotonergic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Ostarine has documented interactions with 6 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate), hepatotoxic drugs (moderate) and probenecid (benemid) (moderate) — and none of Buspirone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Ostarine Does Interact With Other Medications
Ostarine has 440 moderate, 171 minor known drug interactions in our database — Buspirone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ostarine
We haven’t checked that one against Ostarine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ostarine. Pick one to open its full report.
Questions About Ostarine or Buspirone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ostarine or Buspirone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- How Long Does Buspirone Stay in Your System? ›
- Questions About Combining Hydroxyzine And Buspirone ›
- Does Buspar (Buspirone) Work Right Away? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Buspirone
This page covers Ostarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Buspirone page lists 155 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).
By severity: 4 major · 108 moderate · 43 minor.
From our pharmacist’s overview on the Buspirone page
“I counsel genuine caution when supplements meet buspirone (BuSpar), the anxiety medication, because four of its 155 documented interactions are rated major. The bulk of the list, 121 ingredients, changes how your liver clears buspirone through the CYP3A4 enzyme, pushing its level up toward dizziness and drowsiness or down until the anx…”
Reviewed by 2 · Jul 18, 2026
Taking Ostarine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 33 real supplement products containing Ostarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ostarine. Even though Ostarine itself has no known interaction with Buspirone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ostarine and Buspirone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,265 of 1,452 supplements looked up here in the last 7 days
#55 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ostarine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ostarine and Buspirone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ostarine
What is Ostarine?
- Muscle building
- Athletic performance
- Fat loss / body recomposition
- Bodybuilding cycles
Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by the FDA, is banned in sports, and has been linked to liver injury and other serious harms, so it is not recommended for general use.
Synthetic compound (not from a plant) · Capsules, tablets, liquids, powders sold as research chemicals or 'sports supplements'
An interaction check asks whether these two react with each other — it does not ask whether Ostarine is a good idea for someone in your situation. Here is what our Ostarine record says about it on its own.
Ostarine: dosing
There is no established safe or approved dose of Ostarine, because it is not an approved medicine or a legitimate dietary supplement. Doses used in research studies were given under medical supervision and do not apply to over-the-counter use.We do not recommend using Ostarine. Products sold online may not contain the dose listed on the label and may include other hidden substances.
From our Ostarine monograph — the full record covers uses, side effects and every documented interaction.
About Buspirone
What Is Buspirone Used For?
Brand name: BuSpar
Buspirone tablets and capsules are used to manage anxiety disorders or to relieve anxiety symptoms in the short term. Its effectiveness has been shown in clinical trials focused on Generalized Anxiety Disorder (GAD) — a condition marked by persistent, hard-to-control worry along with physical symptoms like muscle tension, restlessness, difficulty concentrating, and sleep problems.
Buspirone has also been shown to relieve anxiety in people who have mild depressive symptoms alongside their anxiety. Everyday stress and tension, on their own, generally do not require treatment with a medicine like buspirone.
Other Drugs & Ostarine
Browse every other medication we’ve checked against Ostarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
440 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Phenytoin ›
- Allopurinol ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Acetaminophen ›
- Griseofulvin ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Acarbose ›
- Dapsone ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Modafinil ›
- Naltrexone ›
- Phenobarbital ›
- Probenecid ›
- Riluzole ›
- Valproic Acid ›
- Abiraterone Acetate ›
- Acebutolol ›
- Ambrisentan ›
- Amiodarone ›
- Aprepitant ›
- Azathioprine ›
- Chlorpropamide ›
- Choline Magnesium Trisalicylate ›
- Cyclophosphamide ›
- Daclizumab ›
- Dantrolene ›
- Deferasirox ›
- Diclofenac Epolamine ›
- Fingolimod ›
- Fluconazole ›
- Fluvastatin ›
Showing 60 of 440 moderate interactions — see all 440 on the Ostarine page.
171 interactions
- Diltiazem ›
- Ibuprofen ›
- Metronidazole ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Norethindrone ›
- Prednisone ›
- Flurbiprofen ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Trimipramine ›
- Diazepam ›
- Everolimus ›
- Meloxicam ›
- Cimetidine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Nicardipine ›
- Omeprazole ›
- Warfarin Sodium ›
- Carvedilol ›
- Celecoxib ›
- Clarithromycin ›
- Clomipramine ›
- Danazol ›
- Dronabinol ›
- Fluoxetine ›
- Fosamprenavir ›
- Glipizide ›
- Imipramine ›
- Irbesartan ›
- Lacosamide ›
- Methylprednisolone ›
- Mifepristone ›
- Octreotide ›
- Piroxicam ›
- Quinine Sulfate ›
- Saquinavir ›
- Tapentadol ›
- Torsemide ›
- Valsartan ›
- Abametapir ›
- Abrocitinib ›
- Acitretin ›
- Agomelatine ›
- Amitriptyline ›
- Amprenavir ›
- Asciminib ›
- Atazanavir ›
- Azilsartan ›
- Berotralstat Hydrochloride ›
- Boceprevir ›
- Brigatinib ›
- Clopidogrel ›
- Cobicistat ›
- Crizotinib ›
- Darunavir ›
- Delavirdine Mesylate ›
Showing 60 of 171 minor interactions — see all 171 on the Ostarine page.
No interaction 2,218 drugs checked — show the list
We also checked Ostarine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Metoprolol ›
- Ivermectin ›
- Aspirin ›
- Rivaroxaban ›
- Escitalopram ›
- Tadalafil ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Propranolol ›
- Bupropion ›
- Lisdexamfetamine ›
- Metformin ›
- Acyclovir ›
- Lisinopril ›
- Bendamustine ›
- Lamotrigine ›
- Amphetamine ›
- Gabapentin ›
- Pregabalin ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Letrozole ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Mannitol ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Mirtazapine ›
- Finasteride ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Levetiracetam ›
- Dexmethylphenidate ›
- Spironolactone ›
- Amlodipine Besylate, Benazepril ›
- Alprazolam ›
- Factor 7a ›
- Bromocriptine ›
- Dutasteride ›
- Carbidopa, Levodopa ›
Showing the 60 most looked-up of 2,218 medications checked with no known interaction — see the full Ostarine list.
Ostarine References
The 10 references that drive our Ostarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
- Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
- Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024 (enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs 2016;34(4):458-67. PubMed
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
- Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
- Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
- Weinblatt D, Roy S. Drug-Induced Liver Injury Secondary to Enobosarm: A Selective Androgen Receptor Modulator. J Med Cases 2022;13(5):244-248. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ostarine and Buspirone Together: Common Questions
Is it safe to take Ostarine with Buspirone?
Do Ostarine and Buspirone have any of the same side effects?
How was the Ostarine and Buspirone combination checked?
Does Ostarine interact with any other medications?
Does Buspirone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.