Ostarine + Levothyroxine Sodium
Levothyroxine Sodium brand names: Tirosint-Sol, Thyquidity, Ermez.
We found no known interaction between Ostarine and Levothyroxine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Levothyroxine Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Ostarine and Levothyroxine Sodium
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Levothyroxine Sodium and Ostarine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Ostarine safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Levothyroxine Sodium
Interactions in our licensed database are recorded against drug classes, not just single drug names. Levothyroxine Sodium is filed under 3 classifications — including thyroid hormone, oral drugs. Ostarine has documented interactions with 6 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate), hepatotoxic drugs (moderate) and probenecid (benemid) (moderate) — and none of Levothyroxine Sodium’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Ostarine Does Interact With Other Medications
Ostarine has 440 moderate, 171 minor known drug interactions in our database — Levothyroxine Sodium isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Ostarine
We haven’t checked that one against Ostarine yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Ostarine. Pick one to open its full report.
Some Levothyroxine Sodium Products Have a Food Rule — Ostarine Should Not Break It
At least one FDA label for a product containing Levothyroxine Sodium says to take it on an empty stomach. Most supplements — Ostarine included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine Sodium on its own and move Ostarine to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Levothyroxine Sodium
This page covers Ostarine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine Sodium page lists 50 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).
Taking Ostarine as Part of a Dietary Supplement Product? Check It for Interactions
We hold 33 real supplement products containing Ostarine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ostarine. Even though Ostarine itself has no known interaction with Levothyroxine Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Ostarine and Levothyroxine Sodium Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,283 of 1,452 supplements looked up here in the last 7 days
#126 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ostarine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ostarine and Levothyroxine Sodium records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Ostarine
What is Ostarine?
- Muscle building
- Athletic performance
- Fat loss / body recomposition
- Bodybuilding cycles
Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by the FDA, is banned in sports, and has been linked to liver injury and other serious harms, so it is not recommended for general use.
Synthetic compound (not from a plant) · Capsules, tablets, liquids, powders sold as research chemicals or 'sports supplements'
An interaction check asks whether these two react with each other — it does not ask whether Ostarine is a good idea for someone in your situation. Here is what our Ostarine record says about it on its own.
Ostarine: dosing
There is no established safe or approved dose of Ostarine, because it is not an approved medicine or a legitimate dietary supplement. Doses used in research studies were given under medical supervision and do not apply to over-the-counter use.We do not recommend using Ostarine. Products sold online may not contain the dose listed on the label and may include other hidden substances.
From our Ostarine monograph — the full record covers uses, side effects and every documented interaction.
About Levothyroxine Sodium
Most-Reported Side Effects for Levothyroxine Sodium
From FAERS, the FDA’s public side-effect reporting system (312,551 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Ostarine
Browse every other medication we’ve checked against Ostarine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
440 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Phenytoin ›
- Allopurinol ›
- Carbamazepine ›
- Diclofenac Potassium ›
- Acetaminophen ›
- Griseofulvin ›
- Methotrexate ›
- Nitrofurantoin ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Acarbose ›
- Dapsone ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Modafinil ›
- Naltrexone ›
- Phenobarbital ›
- Probenecid ›
- Riluzole ›
- Valproic Acid ›
- Abiraterone Acetate ›
- Acebutolol ›
- Ambrisentan ›
- Amiodarone ›
- Aprepitant ›
- Azathioprine ›
- Chlorpropamide ›
- Choline Magnesium Trisalicylate ›
- Cyclophosphamide ›
- Daclizumab ›
- Dantrolene ›
- Deferasirox ›
- Diclofenac Epolamine ›
- Fingolimod ›
- Fluconazole ›
- Fluvastatin ›
Showing 60 of 440 moderate interactions — see all 440 on the Ostarine page.
171 interactions
- Diltiazem ›
- Ibuprofen ›
- Metronidazole ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Norethindrone ›
- Prednisone ›
- Flurbiprofen ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Trimipramine ›
- Diazepam ›
- Everolimus ›
- Meloxicam ›
- Cimetidine ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Nicardipine ›
- Omeprazole ›
- Warfarin Sodium ›
- Carvedilol ›
- Celecoxib ›
- Clarithromycin ›
- Clomipramine ›
- Danazol ›
- Dronabinol ›
- Fluoxetine ›
- Fosamprenavir ›
- Glipizide ›
- Imipramine ›
- Irbesartan ›
- Lacosamide ›
- Methylprednisolone ›
- Mifepristone ›
- Octreotide ›
- Piroxicam ›
- Quinine Sulfate ›
- Saquinavir ›
- Tapentadol ›
- Torsemide ›
- Valsartan ›
- Abametapir ›
- Abrocitinib ›
- Acitretin ›
- Agomelatine ›
- Amitriptyline ›
- Amprenavir ›
- Asciminib ›
- Atazanavir ›
- Azilsartan ›
- Berotralstat Hydrochloride ›
- Boceprevir ›
- Brigatinib ›
- Clopidogrel ›
- Cobicistat ›
- Crizotinib ›
- Darunavir ›
- Delavirdine Mesylate ›
Showing 60 of 171 minor interactions — see all 171 on the Ostarine page.
No interaction 2,218 drugs checked — show the list
We also checked Ostarine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Escitalopram ›
- Tadalafil ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Lisinopril ›
- Bendamustine ›
- Lamotrigine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
- Pegunigalsidase Alfa-iwxj ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
- Mirtazapine ›
- Finasteride ›
- Hexobarbitone ›
- Dexmethylphenidate ›
- Levetiracetam ›
- Alprazolam ›
- Amlodipine Besylate, Benazepril ›
- Bromocriptine ›
- Dutasteride ›
- Mitomycin ›
- Minoxidil ›
- Aripiprazole ›
Showing the 60 most looked-up of 2,218 medications checked with no known interaction — see the full Ostarine list.
Ostarine References
The 10 references that drive our Ostarine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
- Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
- Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024 (enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs 2016;34(4):458-67. PubMed
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
- Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
- Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
- Weinblatt D, Roy S. Drug-Induced Liver Injury Secondary to Enobosarm: A Selective Androgen Receptor Modulator. J Med Cases 2022;13(5):244-248. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Ostarine and Levothyroxine Sodium Together: Common Questions
Is it safe to take Ostarine with Levothyroxine Sodium?
Do Ostarine and Levothyroxine Sodium have any of the same side effects?
Should I take Ostarine and Levothyroxine Sodium at the same time of day?
How was the Ostarine and Levothyroxine Sodium combination checked?
Does Ostarine interact with any other medications?
Does Levothyroxine Sodium interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.