Bulbous Buttercup + Edaravone
Edaravone brand names: Radicava, Radicava ORS.
We found no known interaction between Bulbous Buttercup and Edaravone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Edaravone states a food rule worth keeping to.
Bulbous Buttercup and Edaravone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Edaravone and Bulbous Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Bulbous Buttercup at all — not against Edaravone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Bulbous Buttercup safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Bulbous Buttercup in Pregnancy & Breastfeeding
When used orally or topically; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Edaravone Products Have a Food Rule — Bulbous Buttercup Should Not Break It
At least one FDA label for a product containing Edaravone says to take it on an empty stomach. Most supplements — Bulbous Buttercup included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Edaravone on its own and move Bulbous Buttercup to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Edaravone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
RADICAVA ORS should be taken in the morning on an empty stomach after overnight fasting.
From the Dosage and Administration section of the FDA label we read for Edaravone — where that label names a specific product, the instruction is that product's. See the Edaravone drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Edaravone
This page covers Bulbous Buttercup only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Edaravone page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Taking Bulbous Buttercup as Part of a Dietary Supplement Product? Check It for Interactions
We hold 4 real supplement products containing Bulbous Buttercup, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bulbous Buttercup. Even though Bulbous Buttercup itself has no known interaction with Edaravone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Bulbous Buttercup and Edaravone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,415 of 1,452 supplements looked up here in the last 7 days
#746 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bulbous Buttercup reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bulbous Buttercup and Edaravone records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Bulbous Buttercup
What is Bulbous Buttercup?
- Nerve pain and shingles-related discomfort (homeopathic use)
- Muscle and chest wall pain
- Skin blistering and eruptions (traditional)
- Rheumatic aches (folk use)
Bulbous buttercup is a wild flowering plant that is toxic and irritating when fresh, and it is used today mainly in heavily diluted homeopathic remedies. There is no solid scientific evidence that it treats any medical condition, and the raw plant can cause serious skin and digestive harm, so it should not be eaten or applied directly.
Ranunculus bulbosus · Ranunculaceae · Whole fresh plant, leaves, and flowers (mainly used in homeopathic preparations) · Homeopathic dilutions (pellets, liquid), rarely topical folk preparations
An interaction check asks whether these two react with each other — it does not ask whether Bulbous Buttercup is a good idea for someone in your situation. Here is what our Bulbous Buttercup record says about it on its own.
Bulbous Buttercup: dosing
There is no established safe or effective dose of bulbous buttercup for any health condition. The raw plant should not be taken at all.If a homeopathic product is used, follow the directions on the label, since potencies and dosing vary widely between products.
From our Bulbous Buttercup monograph — the full record covers uses, side effects and every documented interaction.
About Edaravone Oral
What Is Edaravone Oral Used For?
Brand names: Radicava, Radicava ORS
-
Edaravone is used to treat amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease; a condition in which the nerves that control muscle movement slowly die, causing the muscles to shrink and weaken). Edaravone is in a class of medications called antioxidants. It may work to slow the nerve damage associated with the worsening of ALS symptoms.
Most-Reported Side Effects for Edaravone
From FAERS, the FDA’s public side-effect reporting system (1,540 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Bulbous Buttercup
Browse every other medication we’ve checked against Bulbous Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Bulbous Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Amitriptyline ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Bulbous Buttercup list.
Bulbous Buttercup References
The 1 references that drive our Bulbous Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Bulbous Buttercup and Edaravone Together: Common Questions
Is it safe to take Bulbous Buttercup with Edaravone?
Should I take Bulbous Buttercup and Edaravone at the same time of day?
Does Edaravone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.