Buttercup + Collagenase Clostridium Histolyticum-Aaes
Collagenase Clostridium Histolyticum-Aaes brand name: Qwo.
We found no known interaction between Buttercup and Collagenase Clostridium Histolyticum-Aaes in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Buttercup and Collagenase Clostridium Histolyticum-Aaes
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Collagenase Clostridium Histolyticum-Aaes and Buttercup in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Buttercup at all — not against Collagenase Clostridium Histolyticum-Aaes, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Buttercup safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Buttercup in Pregnancy & Breastfeeding
When the fresh plant is used orally or topically. Buttercup might also stimulate uterine contractions. There is insufficient reliable information available about the safety of the dried above ground parts of buttercup used during pregnancy and lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Where Buttercup and Collagenase Clostridium Histolyticum-Aaes Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,264 of 1,452 supplements looked up here in the last 7 days
#154 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Buttercup reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Buttercup and Collagenase Clostridium Histolyticum-Aaes records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Buttercup
What is Buttercup?
- Joint and muscle pain (traditional topical use)
- Skin conditions and blisters
- Nerve pain (traditional folk use)
- Rheumatic complaints
Buttercup refers to plants in the Ranunculus family, which contain an irritating compound that makes the fresh plant toxic to eat and harsh on skin. There is no good scientific evidence that it safely treats any health condition, and it can cause serious irritation and poisoning. We do not recommend using fresh buttercup as a supplement.
Ranunculus spp. · Ranunculaceae · Whole plant, leaves, and flowers (fresh or dried) · Topical preparations, homeopathic remedies, traditional poultices, and dried herb
An interaction check asks whether these two react with each other — it does not ask whether Buttercup is a good idea for someone in your situation. Here is what our Buttercup record says about it on its own.
Buttercup: dosing
There is no established safe dose of buttercup for internal use, and we do not recommend taking it by mouth. The plant is toxic in its fresh form, and standardized supplement products are not available from reputable sources.Any homeopathic preparations are extremely diluted and are a different category of product.
From our Buttercup monograph — the full record covers uses, side effects and every documented interaction.
About Collagenase Clostridium histolyticum Injection
What Is Collagenase Clostridium histolyticum Injection Used For?
Brand name: Qwo
-
Collagenase Clostridium histolyticum injection (Xiaflex) is used to treat Dupuytren's contracture (a painless thickening and tightening of tissue [cord] beneath the skin in the palm of the hand, which may make it difficult to straighten one or more fingers) when a cord of tissue can be felt upon examination. Collagenase Clostridium histolyticum injection (Xiaflex) is also used to treat Peyronie's disease (a thickening of tissue [plaque] inside the penis that causes the penis to curve). Collagenase Clostridium histolyticum injection (QWO) is also used to treat cellulite (fat deposit beneath the skin) in the buttocks of adult women. Collagenase Clostridium histolyticum injection is in a class of medications called enzymes. In people with Dupuytren's contracture, it works by helping to break down the cord of thickened tissue and allows the finger(s) to be straightened. In people with Peyronie's disease, it works by helping to break down the plaque of thickened tissue and allows the penis to be straightened. In women with cellulite, it works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen.
Other Drugs & Buttercup
Browse every other medication we’ve checked against Buttercup — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Buttercup against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Ivermectin ›
- Abemaciclib ›
- Rosuvastatin ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Testosterone ›
- Aspirin ›
- Clopidogrel ›
- Metoprolol ›
- Escitalopram ›
- Atorvastatin ›
- Rivaroxaban ›
- Warfarin Sodium ›
- Levothyroxine, Liothyronine ›
- Ibuprofen ›
- Tirzepatide ›
- Isotretinoin ›
- Metformin ›
- Docusate ›
- Amlodipine Besylate ›
- Prednisone ›
- Tadalafil ›
- Propranolol ›
- Semaglutide ›
- Amphetamine ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Methamphetamine ›
- Lisinopril ›
- Sumatriptan ›
- Amoxicillin ›
- Valacyclovir ›
- Hydroxyurea ›
- Bupropion ›
- Fluoxetine ›
- Methotrexate ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Clonazepam ›
- Lamotrigine ›
- Buspirone ›
- Quetiapine ›
- Dextroamphetamine ›
- Acyclovir ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Bendamustine ›
- Methylene Blue ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Buttercup list.
Buttercup References
The 3 references that drive our Buttercup monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- de Maere d'Aertrycke O, Le Polain de Waroux JB, Hantson P, de Bergeyck R. Recurrent supraventricular tachyarrhythmia following Ranunculus acris ("Meadow Buttercup") ingestion. Clin Toxicol (Phila). 2020;58(7):780-781.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Buttercup and Collagenase Clostridium Histolyticum-Aaes Together: Common Questions
Is it safe to take Buttercup with Collagenase Clostridium Histolyticum-Aaes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.