Drug & supplement interaction

Calanus Oil + Obinutuzumab

Obinutuzumab brand name: Gazyva.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Calanus Oil and Obinutuzumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Obinutuzumab states a food rule worth keeping to.

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Interaction report

Calanus Oil and Obinutuzumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Obinutuzumab and Calanus Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Calanus Oil at all — not against Obinutuzumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calanus Oil safety at a glance

Calanus Oil overall Use caution Generally well tolerated in early studies, but long-term safety data in people are limited.
Pregnancy Avoid There is not enough safety information, so it is best to avoid during pregnancy.
Breastfeeding Avoid Safety during breastfeeding has not been established, so avoid unless your doctor advises otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Obinutuzumab and Calanus Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Calanus Oil Itself Has Been Linked To

This is not an interaction — nothing below involves Obinutuzumab. It is the side-effect record for Calanus Oil on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Calanus Oil, this list is the first place to look.

  • A skin rash Additional detail

    “Calanus oil seems to be well tolerated. In one safety study, taking calanus oil for 12 months was reported to cause a higher rate of mild atopic dermatitis (eczema) when compared with placebo.”

    Calanus Oil · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 97880. Cook CM, Larsen TS, Derrig LD, Kelly KM, Tande KS. Wax ester rich oil from the marine crustacean, Calanus finmarchicus, is a bioavailable source of EPA and DHA for human consumption. Lipids. 2016;51(10):1137-1144.
    2. 97881. Tande KS, Vo TD, Lynch BS. Clinical safety evaluation of marine oil derived from Calanus finmarchicus. Regul Toxicol Pharmacol. 2016;80:25-31. PubMed
    3. 105408. Dadová K, Petr M, Steffl M, et al. Effect of calanus oil supplementation and 16 week exercise program on selected fitness parameters in older women. Nutrients. 2020 Feb 14;12(2):481. PubMed

    “Orally, calanus oil is associated with more reports of mild atopic dermatitis (eczema) over a 12-month period when compared with placebo.”

    Calanus Oil · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 97881. Tande KS, Vo TD, Lynch BS. Clinical safety evaluation of marine oil derived from Calanus finmarchicus. Regul Toxicol Pharmacol. 2016;80:25-31. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Calanus Oil — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Obinutuzumab’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Obinutuzumab column appears here.

How to take them

Some Obinutuzumab Products Have a Food Rule — Calanus Oil Should Not Break It

At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach. Most supplements — Calanus Oil included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Obinutuzumab on its own and move Calanus Oil to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Obinutuzumab products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

650–1,000 mg acetaminophen At least 30 minutes before GAZYVA infusion.

From the Dosage and Administration section of the FDA label we read for Obinutuzumab — where that label names a specific product, the instruction is that product's. See the Obinutuzumab drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

How much people look this up

Where Calanus Oil and Obinutuzumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calanus Oil
Steady interest

#1,236 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Obinutuzumab
Steady interest

#1,744 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calanus Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Calanus Oil and Obinutuzumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calanus Oil

What is Calanus Oil?

  • Heart and metabolic health
  • Source of omega-3 fatty acids
  • Anti-inflammatory support
  • General wellness
  • Exercise and weight management

Calanus oil is a marine omega-3 oil made from a small Arctic zooplankton (Calanus finmarchicus). It is rich in omega-3 fatty acids bound in a unique 'wax ester' form, and early research suggests possible benefits for metabolic and heart health, but the evidence is still preliminary. Talk with your pharmacist or doctor before using it, especially if you have a seafood allergy or are pregnant.

Calanus finmarchicus · Calanidae · Oil extracted from the whole copepod (a tiny marine zooplankton) · Softgel capsules, oil

An interaction check asks whether these two react with each other — it does not ask whether Calanus Oil is a good idea for someone in your situation. Here is what our Calanus Oil record says about it on its own.

Calanus Oil: dosing

There is no official, standardized dose of calanus oil. Studies have used a fairly small daily amount, often just a gram or two per day, but products and concentrations vary.The best approach is to follow the dose printed on the product label and not exceed it.

From our Calanus Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calanus Oil monograph & all interactions
Medication

About Obinutuzumab Injection

What Is Obinutuzumab Injection Used For?

Brand name: Gazyva

Gazyva is used to treat three conditions. For chronic lymphocytic leukemia (CLL), it is given in combination with chlorambucil in patients who have not been treated before. For follicular lymphoma (FL), it is used either with bendamustine (for patients whose disease came back or stopped responding to a rituximab-based regimen) or with chemotherapy (for previously untreated advanced disease) — in both cases followed by Gazyva alone as maintenance therapy.

Gazyva is also approved for active lupus nephritis — a type of kidney inflammation caused by lupus — in adults who are already receiving standard therapy for the condition.

See full Obinutuzumab Injection drug information
Keep checking

Other Drugs & Calanus Oil

Browse every other medication we’ve checked against Calanus Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Calanus Oil References

The 3 references that drive our Calanus Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cook CM, Larsen TS, Derrig LD, Kelly KM, Tande KS. Wax ester rich oil from the marine crustacean, Calanus finmarchicus, is a bioavailable source of EPA and DHA for human consumption. Lipids. 2016;51(10):1137-1144.
  2. Tande KS, Vo TD, Lynch BS. Clinical safety evaluation of marine oil derived from Calanus finmarchicus. Regul Toxicol Pharmacol. 2016;80:25-31. PubMed
  3. Dadová K, Petr M, Steffl M, et al. Effect of calanus oil supplementation and 16 week exercise program on selected fitness parameters in older women. Nutrients. 2020 Feb 14;12(2):481. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calanus Oil and Obinutuzumab Together: Common Questions

Is it safe to take Calanus Oil with Obinutuzumab?
We do not list a known interaction between Calanus Oil and Obinutuzumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Calanus Oil and Obinutuzumab at the same time of day?
At least one FDA label for a product containing Obinutuzumab says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Obinutuzumab on its own and move Calanus Oil to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Obinutuzumab and Calanus Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.