Ceylon Cinnamon - Zestril (Lisinopril) Interaction
Herbal: Ceylon Cinnamon
Also Known As: Cinnamomum verum, Batavia Cassia, Batavia Cinnamon, Canela, Canelero de Ceilán, Cannelier de Ceylan, Cannelle de Ceylan, Cannelle de Saïgon, Cannelle du Sri Lanka, Ceylonzimt, Ceylonzimtbaum, Cinnamon Bark, Corteza de Canela, Dalchini, Écorce de Cannelle, Echter Ceylonz
Drug: Lisinopril
Brand names:
Zestril, Prinivil, Qbrelis
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Lisinopril is classified as belonging to the following category: Antihypertensive Drugs
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
- Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
Ceylon Cinnamon Overview
Ceylon cinnamon, sometimes known as "true" cinnamon, is a type of cinnamon that is native to Sri Lanka. It is a member of the Cinnamomum verum species and is known for its light, sweet flavor and light brown color. Ceylon cinnamon is considered to be of higher quality and is more expensive than other types of cinnamon, such as cassia cinnamon (which is more common in the United States).
Ceylon cinnamon is often used in cooking and baking to add spice and flavor to dishes. The bark of Ceylon cinnamon, which contains cinnamaldehyde, is used in traditional medicine treat a variety of conditions, including indigestion, diabetes, and high cholesterol.
Lisinopril Overview
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Lisinopril is used alone or in combination with other medications to treat high blood pressure in adults and children 6 years of age and older. It is used in combination with other medications to treat heart failure. Lisinopril is also used to improve survival after a heart attack. Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.
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High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Ceylon Cinnamon - More Interactions
Ceylon Cinnamon interacts with 253 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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