Drug & supplement interaction

Chrysanthemum + Denosumab

Denosumab brand names: Prolia, XGEVA.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chrysanthemum and Denosumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chrysanthemum and Denosumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Denosumab and Chrysanthemum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Chrysanthemum at all — not against Denosumab, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chrysanthemum safety at a glance

Chrysanthemum overall Use caution Generally well tolerated as a tea, but it can cause allergic reactions in sensitive people.
Pregnancy Avoid Safety during pregnancy has not been established, so it is best avoided unless your doctor approves.
Breastfeeding Avoid There is not enough reliable information on safety while breastfeeding, so caution or avoidance is wise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Denosumab and Chrysanthemum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Chrysanthemum and Denosumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives / An allergic reaction Worth acting on Additional detail

    Chrysanthemum

    “Topically and via occupational exposure, chrysanthemum can cause allergic reactions. Chrysanthemum allergy symptoms can include urticaria, contact dermatitis, eczema, actinic reticuloid photosensitivity dermatitis, pollinosis, rhinoconjunctivitis, and asthma. There are numerous case reports and studies showing that allergies to Chrysanthemum are very common, with an estimated 60% of Europeans being allergic.”

    Chrysanthemum · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 5552. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
    2. 5554. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
    3. 5556. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
    4. 5557. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
    5. 6958. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
    6. 42842. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed

    Denosumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Denosumab. Read the label on DailyMed ›

  • A skin rash Additional detail

    Chrysanthemum

    Recorded for Chrysanthemum in the same Natural Medicines adverse-effect record shown under Hives / An allergic reaction above.

    Denosumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Denosumab. Read the label on DailyMed ›

Reported for Chrysanthemum but not commonly for Denosumab: sun sensitivity and wheezing.

Effects for Denosumab come from the ADVERSE REACTIONS section of its FDA label; effects for Chrysanthemum come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Denosumab

This page covers Chrysanthemum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Denosumab page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), American Ginseng (moderate), Andrographis (moderate) and Ashwagandha (moderate).

By severity: 53 moderate · 2 minor.

From our pharmacist’s overview on the Denosumab page

“The typical person on denosumab (Prolia, XGEVA) is protecting bone, from osteoporosis or from cancer that has spread there, and many also reach for echinacea, ashwagandha, or ginseng to prop up their immune system. That overlap is the whole list.”

Reviewed by 2 · Jul 18, 2026

Open the Denosumab interaction page

One more smart check

Taking Chrysanthemum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Chrysanthemum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chrysanthemum. Even though Chrysanthemum itself has no known interaction with Denosumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chrysanthemum and Denosumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chrysanthemum
Steady interest

#1,180 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Denosumab
Steady interest

#1,479 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chrysanthemum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chrysanthemum and Denosumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chrysanthemum

What is Chrysanthemum?

  • Eye irritation and tired eyes
  • Cooling and 'heat-clearing' in traditional Chinese medicine
  • Cold and flu symptoms
  • Headache
  • Soothing/relaxation
  • High blood pressure (traditional use)

Chrysanthemum flowers are most often used as a soothing tea in traditional Chinese medicine and as a folk remedy for eye irritation, colds, and minor inflammation. Solid human evidence for these uses is limited, so it should be seen as a pleasant traditional drink rather than a proven treatment. People allergic to ragweed and related plants, and those who are pregnant or breastfeeding, should be cautious and talk to a pharmacist or doctor first.

Chrysanthemum morifolium · Asteraceae · Flowers (dried flower heads) · Tea, dried flowers, capsules, extracts, topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Chrysanthemum is a good idea for someone in your situation. Here is what our Chrysanthemum record says about it on its own.

Chrysanthemum: dosing

There is no official standardized dose for chrysanthemum. It is most often used as a tea made from dried flowers, and supplement strength varies widely between products.If you choose to use it, follow the directions on the product label and start with a small amount to see how you react.

From our Chrysanthemum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chrysanthemum monograph & all interactions
Medication

About Denosumab Injection

What Is Denosumab Injection Used For?

Brand names: Prolia, XGEVA

Jubbonti (denosumab) injection is used to treat osteoporosis in postmenopausal women and men at high risk for fracture, including those who have already had a fracture or who have not responded to other osteoporosis medicines. It is also used to treat osteoporosis caused by long-term steroid (glucocorticoid) use in men and women.

Jubbonti is additionally used to increase bone mass in men receiving androgen deprivation therapy (a hormone-lowering treatment) for nonmetastatic prostate cancer, and in women receiving aromatase inhibitor therapy for breast cancer — both of which can weaken bones over time.

See full Denosumab Injection drug information
Keep checking

Other Drugs & Chrysanthemum

Browse every other medication we’ve checked against Chrysanthemum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Chrysanthemum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Chrysanthemum list.

See the full Chrysanthemum interactions page
See every supplement checked against Denosumab, ranked by severity
Evidence & sources

Chrysanthemum References

The 25 references that drive our Chrysanthemum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kuno Y, Kawabe Y, Sakakibara S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40:224-5. PubMed
  2. deJong NW, Vermeulen AM, van Wijik RG, deGroot H. Occupational allergy caused by flowers. Allergy 1998;53:204-9. PubMed
  3. Camplimi P, Sertoli A, Fabbri P, Panconesi E. Alantolactone sensitivity in chrysanthemum contact dermatitis. Contact Dermatitis 1978;4:93-102. PubMed
  4. Bleumink E, Mitchell JC, Geismann TA, Towers GH. Contact hypersensitivity to sesquiterpene lactones in Chrysanthemum dermatitis. Contact Dermatitis 1976;2:81-8.
  5. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  6. Hausen BM. The sensitizing capacity of Compositae plants. III. Test results and cross-reactions in Compositae-sensitive patients. Dermatologica 1979;159:1-11. DOI
  7. Kuno, Y., Kawabe, Y., and Sakakibara, S. Allergic contact dermatitis associated with photosensitivity, from alantolactone in a chrysanthemum farmer. Contact Dermatitis 1999;40(4):224-225. PubMed
  8. Schulz, K. H., Hausen, B. M., Wallhofer, L., and Schmidt-Loffler, P. Chrysanthemum allergy. Pt. II: Experimental studies on the causative agents. Arch.Dermatol.Forsch. 1975;251(3):235-244.
  9. Singhal, V. and Reddy, B. S. Common contact sensitizers in Delhi. J Dermatol 2000;27(7):440-445. PubMed
  10. Kuroume, T., Todokoro, M., Tomidokoro, H., Kanbe, Y., and Matsumura, T. Chrysanthemum pollinosis in Japan. Int.Arch.Allergy Appl.Immunol. 1975;48(6):800-811.
  11. Groenewoud, G. C., de Jong, N. W., Burdorf, A., de Groot, H., and van Wyk, R. G. Prevalence of occupational allergy to Chrysanthemum pollen in greenhouses in the Netherlands. Allergy 2002;57(9):835-840.
  12. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  13. Hashimoto, Y., Kawada, A., Aragane, Y., and Tezuka, T. Occupational contact dermatitis from chrysanthemum in a mortician. Contact Dermatitis 2003;49(2):106-107. PubMed
  14. Groenewoud, G. C., de Groot, H., and van Wijk, R. G. Impact of occupational and inhalant allergy on rhinitis-specific quality of life in employees of bell pepper greenhouses in the Netherlands. Ann Allergy Asthma Immunol 2006;96(1):92-97. PubMed
  15. Sharma, S. C. and Kaur, S. Airborne contact dermatitis from Compositae plants in northern India. Contact Dermatitis 1989;21(1):1-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chrysanthemum and Denosumab Together: Common Questions

Is it safe to take Chrysanthemum with Denosumab?
We do not list a known interaction between Chrysanthemum and Denosumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chrysanthemum and Denosumab have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Denosumab interact with any supplements?
Yes. Denosumab has documented interactions with 55 supplements in our database — Chrysanthemum is not one of them. The Denosumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chrysanthemum monograph Uses, safety profile, and every drug interaction in one place Denosumab Injection drug information The full plain-English guide to this medication Denosumab supplement interactions Every supplement checked against Denosumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Denosumab and Chrysanthemum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.