Coenzyme Q10 - Doxycycline Hyclate Interaction
Herbal: Coenzyme Q10
Also Known As: CoQ10
Drug: Doxycycline Hyclate
Brand names:
Acticlate, Acticlate Cap, Lymepak

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Doxycycline Hyclate and Coenzyme Q10. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Although CoQ10 is considered relatively safe for most individuals, it does have some reported interactions that are important to be aware of.
This includes:
- Antihypertensives: Clinical research has shown that CoQ10 can significantly lower blood pressure but conflicting results have been reported.
- Warfarin: Research is conflicting but concomitant use of CoQ10 and warfarin might reduce the anticoagulant effects of warfarin.
- Alkylating Agents: Antioxidants such as CoQ10 might also protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy.
Outside of the interactions I've listed above, CoQ10 is generally considered safe to supplement with in most situations.
In fact, some individuals taking certain medications (e.g., 'Statins') may be recommended to take it.
If you have any questions about CoQ10 supplements, be sure to speak to your healthcare professional. We are always happy to answer questions on the matter as well!
- Dr. Brian Staiger, PharmDCoenzyme Q10 Overview
Doxycycline Hyclate Overview
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Doxycycline is used to treat a variety of infections caused by certain types of bacteria. Doxycycline is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in people who may have been exposed to anthrax in the air and to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). It is also used to prevent malaria. Doxycycline is also used along with other medications to treat acne and rosacea (a skin disease that causes redness, flushing, and pimples on the face). Doxycycline (Oracea) is used only to treat pimples and bumps caused by rosacea. Doxycycline is in a class of medications called tetracycline antibiotics. It works to treat infections by preventing the growth and spread of bacteria. It works to treat acne by killing the bacteria that infects pores and decreasing a certain natural oily substance that causes acne. It works to treat rosacea by decreasing the inflammation that causes this condition.
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Antibiotics such as doxycycline will not work for colds, flu, or other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
Coenzyme Q10 - More Interactions
Coenzyme Q10 interacts with 195 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.