Drug & supplement interaction

Collagen Type I (native) + Ketoprofen

Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Collagen Type I (native) and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Collagen Type I (native) and Ketoprofen

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ketoprofen and Collagen Type I (native) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Collagen Type I (native) at all — not against Ketoprofen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Collagen Type I (native) safety at a glance

Collagen Type I (n... overall Use caution Generally well tolerated for most adults, but quality and source vary widely between products.
Pregnancy Avoid Safety has not been established, so it is best to avoid unless your doctor approves.
Breastfeeding Avoid Not enough safety data exists, so avoid use while breastfeeding unless advised otherwise.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ketoprofen and Collagen Type I (native)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Collagen Type I (native) and Ketoprofen May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Collagen Type I (native)

    “Orally, dyspepsia occurred in one patient in one clinical trial.”

    Collagen Type I (native) · Natural Medicines adverse-effect record, reported in dyspepsia.

    1 source cited
    1. 101769. Stancík R, Zvarka J, Hlavác M, Kubinec V, Rovenský J. Collagen type I in the treatment of painful osteoarthritis of the knee. Reumatologia. 2012;50(5):390-6. DOI

    Ketoprofen

    Listed in the ADVERSE REACTIONS section of the FDA label for Ketoprofen. Read the label on DailyMed ›

Effects for Ketoprofen come from the ADVERSE REACTIONS section of its FDA label; effects for Collagen Type I (native) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 13,040 voluntary FDA FAERS reports for Ketoprofen that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Ketoprofen Products Have a Food Rule — Collagen Type I (native) Should Not Break It

At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Collagen Type I (native) on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.

From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Ketoprofen Is Prescribed For, and What Collagen Type I (native) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ketoprofen is a prescription medicine with approved uses on its FDA label. Collagen Type I (native) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ketoprofen is prescribed for: Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods). Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Collagen Type I (native) has been studied for:

  • Osteoarthritis studied, not established Collagen Type I (native) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Collagen Type I (native) for osteoarthritis

    Oral collagen type I might have a moderate effect on pain and function in patients with osteoarthritis.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ketoprofen on your own; if you are taking Collagen Type I (native) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Ketoprofen

This page covers Collagen Type I (native) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 217 moderate · 28 minor.

From our pharmacist’s overview on the Ketoprofen page

“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”

Reviewed by 2 · Jul 18, 2026

Open the Ketoprofen interaction page

How much people look this up

Where Collagen Type I (native) and Ketoprofen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Collagen Type I (native)
Steady interest

#1,261 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ketoprofen
Top half

#1,091 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Collagen Type I (native) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Collagen Type I (native) and Ketoprofen records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Collagen Type I (native)

What is Collagen Type I (native)?

  • Skin health and wrinkles
  • Joint comfort and arthritis
  • Bone strength
  • Hair and nail support
  • Wound and tissue repair

Type I collagen is the most abundant protein in human skin, bones, and tendons, and it is sold as a supplement to support skin, joints, and bones. 'Native' (undenatured) Type I collagen keeps its natural triple-helix structure rather than being broken down into peptides. Early research is promising for skin and joints, but evidence is still limited, and most products are generally well tolerated.

Skin, bones, tendons, scales, and connective tissue of cows, pigs, fish, or chicken · Powders, capsules, drinks, and undenatured (native) collagen tablets

An interaction check asks whether these two react with each other — it does not ask whether Collagen Type I (native) is a good idea for someone in your situation. Here is what our Collagen Type I (native) record says about it on its own.

Collagen Type I (native): dosing

There is no official standardized dose for native Type I collagen, and the right amount depends on the specific product. Doses used in studies vary widely depending on the form (powder versus tablet) and whether the collagen is native or hydrolyzed.The safest approach is to follow the directions on the product label and not exceed them.

From our Collagen Type I (native) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Collagen Type I (native) monograph & all interactions
Medication

About Ketoprofen

What Is Ketoprofen Used For?

Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection

Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).

Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.

Most-Reported Side Effects for Ketoprofen

From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Headache 1,232 reports
Fatigue 932 reports
Nausea 799 reports
Infusion site pain 764 reports
Fever 756 reports
See full Ketoprofen drug information
Keep checking

Other Drugs & Collagen Type I (native)

Browse every other medication we’ve checked against Collagen Type I (native) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Collagen Type I (native) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Collagen Type I (native) list.

See the full Collagen Type I (native) interactions page
See every supplement checked against Ketoprofen, ranked by severity
Evidence & sources

Collagen Type I (native) References

The 1 references that drive our Collagen Type I (native) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Stancík R, Zvarka J, Hlavác M, Kubinec V, Rovenský J. Collagen type I in the treatment of painful osteoarthritis of the knee. Reumatologia. 2012;50(5):390-6. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Collagen Type I (native) and Ketoprofen Together: Common Questions

Is it safe to take Collagen Type I (native) with Ketoprofen?
We do not list a known interaction between Collagen Type I (native) and Ketoprofen. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Collagen Type I (native) and Ketoprofen have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Collagen Type I (native) and Ketoprofen at the same time of day?
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Collagen Type I (native) on an empty stomach out of habit, keep them separate and take Ketoprofen with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ketoprofen products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Collagen Type I (native) and Ketoprofen used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Collagen Type I (native) in each. That is a conversation for your prescriber, especially if Ketoprofen is being adjusted to a target.
Does Ketoprofen interact with any supplements?
Yes. Ketoprofen has documented interactions with 252 supplements in our database — Collagen Type I (native) is not one of them. The Ketoprofen interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Collagen Type I (native) monograph Uses, safety profile, and every drug interaction in one place Ketoprofen drug information The full plain-English guide to this medication Ketoprofen supplement interactions Every supplement checked against Ketoprofen, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ketoprofen and Collagen Type I (native)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.