Collagen Type Ii (native) + Ketoprofen
Ketoprofen brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection.
We found no known interaction between Collagen Type Ii (native) and Ketoprofen in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ketoprofen states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Collagen Type Ii (native) and Ketoprofen
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ketoprofen and Collagen Type Ii (native) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Collagen Type Ii (native) at all — not against Ketoprofen, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Collagen Type Ii (native) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Ketoprofen Products Have a Food Rule — Collagen Type Ii (native) Should Not Break It
At least one FDA label for a product containing Ketoprofen says to take it with food. If you take Collagen Type Ii (native) on an empty stomach out of habit, keep them separate — and take Ketoprofen with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ketoprofen products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Although food delays the absorption of both formulations (see CLINICAL PHARMACOLOGY ) in most of the clinical trials ketoprofen was taken with food or milk.
From the Dosage and Administration section of the FDA label we read for Ketoprofen — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Ketoprofen Is Prescribed For, and What Collagen Type Ii (native) Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Ketoprofen is a prescription medicine with approved uses on its FDA label. Collagen Type Ii (native) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Ketoprofen is prescribed for: Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods). Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.
Collagen Type Ii (native) has been studied for:
-
Osteoarthritis Natural Medicines rates the evidence for Collagen Type Ii (native): Possibly Effective Read what the research shows
Collagen Type Ii (native) for osteoarthritis
Oral collagen type II seems to improve stiffness, pain, and function by a small amount in patients with knee osteoarthritis, but any benefit on joint space narrowing is unclear.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ketoprofen on your own; if you are taking Collagen Type Ii (native) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Ketoprofen
This page covers Collagen Type Ii (native) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ketoprofen page lists 252 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).
By severity: 7 major · 217 moderate · 28 minor.
From our pharmacist’s overview on the Ketoprofen page
“Bleeding is what worries me most with ketoprofen (Orudis, Oruvail Gel). As an NSAID, it already irritates the stomach lining and slows clotting, and 202 of the 252 supplements and herbs on this page can push that bleeding risk further.”
Reviewed by 2 · Jul 18, 2026
Where Collagen Type Ii (native) and Ketoprofen Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,433 of 1,452 supplements looked up here in the last 7 days
#930 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Collagen Type Ii (native) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Collagen Type Ii (native) and Ketoprofen records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Collagen Type Ii (native)
What is Collagen Type Ii (native)?
- Osteoarthritis and joint pain
- Joint comfort and mobility
- Rheumatoid arthritis
- Exercise-related joint discomfort
- Joint support in active adults
Native (undenatured) type II collagen is a protein from cartilage, usually chicken, taken in small amounts to support joints, especially in osteoarthritis. Some early research is promising, but the overall evidence is still limited and not conclusive. It appears generally well tolerated, but talk with your pharmacist or doctor before starting it.
Cartilage (often from chicken sternum); collagen protein isolated from cartilage · Capsules, tablets, powders (often labeled UC-II or 'undenatured type II collagen')
An interaction check asks whether these two react with each other — it does not ask whether Collagen Type Ii (native) is a good idea for someone in your situation. Here is what our Collagen Type Ii (native) record says about it on its own.
Collagen Type Ii (native): dosing
There is no official standardized dose, but native type II collagen is unusual because it is used in very small daily amounts — far smaller than typical collagen peptide powders. The exact amount depends on the specific product.The best approach is to follow the directions on the product label and not assume more is better.
From our Collagen Type Ii (native) monograph — the full record covers uses, side effects and every documented interaction.
About Ketoprofen
What Is Ketoprofen Used For?
Brand names: Orudis, Oruvail Gel, Powergel, Oruvail Injection
Ketoprofen capsules (including the brand Orudis) are used to manage the signs and symptoms of rheumatoid arthritis and osteoarthritis, to treat pain, and to treat primary dysmenorrhea (painful menstrual periods).
Ketoprofen extended-release capsules are approved for rheumatoid arthritis and osteoarthritis only. Because of the way they slowly release the drug, ketoprofen extended-release capsules are not recommended for treating acute (sudden) pain.
Most-Reported Side Effects for Ketoprofen
From FAERS, the FDA’s public side-effect reporting system (13,040 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Collagen Type Ii (native)
Browse every other medication we’ve checked against Collagen Type Ii (native) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Collagen Type Ii (native) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Collagen Type Ii (native) list.
Collagen Type Ii (native) References
The 5 references that drive our Collagen Type Ii (native) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. Arthritis Rheum 7-15-2008;59(7):905-910 PubMed
- Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, et al Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21. PubMed
- Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.Nutr J. 2016;15:14. doi: 10.1186/s12937-016-0 PubMed
- Wei W, Zhang LL, Xu JH, et al. A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther. 2009;11(6):R180. PubMed
- Thompson DJ, Barron KS, Whitcup SM, Robinson MR. The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis. Ocul Immunol Inflamm. 2002;10(2):83-91. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Ketoprofen Is Linked to Lower Levels of One Nutrient
Natural Medicines records Ketoprofen as a medicine that can lower these. This is not an interaction with Collagen Type Ii (native) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Ketoprofen nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Collagen Type Ii (native) and Ketoprofen Together: Common Questions
Is it safe to take Collagen Type Ii (native) with Ketoprofen?
Do Collagen Type Ii (native) and Ketoprofen have any of the same side effects?
Should I take Collagen Type Ii (native) and Ketoprofen at the same time of day?
Are Collagen Type Ii (native) and Ketoprofen used for the same thing?
Does Ketoprofen interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.