Cramp Bark + Fenofibrate
Fenofibrate brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, and others.
We found no known interaction between Cramp Bark and Fenofibrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Cramp Bark and Fenofibrate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Fenofibrate and Cramp Bark in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Cramp Bark at all — not against Fenofibrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Cramp Bark safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
What Fenofibrate Is Prescribed For, and What Cramp Bark Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Fenofibrate is a prescription medicine with approved uses on its FDA label. Cramp Bark is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Fenofibrate is prescribed for: Fenofibrate is used alongside a cholesterol-lowering diet in adults to improve abnormal lipid levels. Tricor (tablet) and fenofibrate tablets are indicated to lower LDL cholesterol (bad cholesterol), total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL cholesterol (good cholesterol) in adults with primary hypercholesterolemia (high cholesterol) or mixed dyslipidemia (mixed abnormal lipid levels). They are also used to treat severe hypertriglyceridemia (very high triglycerides). Antara and Lipofen (capsules) are indicated to reduce triglyceride levels in adults with severe hypertriglyceridemia, and to lower LDL cholesterol in adults with primary hyperlipidemia when other recommended LDL-lowering therapies cannot be used.
Read the rest of what Fenofibrate is prescribed for
Fenofibrate has not been shown to reduce heart attacks or cardiovascular deaths in patients with type 2 diabetes.
Cramp Bark has been studied for:
-
Diabetes studied, not established Cramp Bark has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Cramp Bark for diabetes
Although there has been interest in using oral Viburnum opulus for diabetes, there is insufficient reliable information about the clinical effects of Viburnum opulus for this purpose.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Fenofibrate on your own; if you are taking Cramp Bark for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Fenofibrate
This page covers Cramp Bark only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenofibrate page lists 59 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).
By severity: 4 major · 46 moderate · 9 minor.
From our pharmacist’s overview on the Fenofibrate page
“Fenofibrate (Tricor, Antara) is a cholesterol and triglyceride medicine that can strain the liver on its own, so this list of 59 supplements deserves genuine care rather than a shrug. Most of it, 38 ingredients, involves herbs that also stress the liver, ashwagandha among them, and stacking those effects is the risk that matters most h…”
Reviewed by 2 · Jul 18, 2026
Taking Cramp Bark as Part of a Dietary Supplement Product? Check It for Interactions
We hold 256 real supplement products containing Cramp Bark, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cramp Bark. Even though Cramp Bark itself has no known interaction with Fenofibrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Cramp Bark and Fenofibrate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#552 of 1,452 supplements looked up here in the last 7 days
#1,058 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cramp Bark and Fenofibrate records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Cramp Bark
What is Cramp Bark?
- Menstrual cramps
- Muscle spasms
- General cramping pain
- Stomach or digestive cramps
- Easing tension
Cramp Bark is the dried bark of Viburnum opulus, traditionally used to ease muscle and menstrual cramps. Modern, high-quality human studies are very limited, so its effectiveness is not well proven. If you want to try it, talk with your pharmacist or doctor first, and avoid it during pregnancy because safety is unclear.
Viburnum opulus · Adoxaceae · Dried bark · Tea (decoction), tincture, liquid extract, capsules
An interaction check asks whether these two react with each other — it does not ask whether Cramp Bark is a good idea for someone in your situation. Here is what our Cramp Bark record says about it on its own.
Cramp Bark: dosing
There is no well-established or standardized dose for Cramp Bark. Products vary widely in strength, especially between teas, tinctures, and capsules.The safest approach is to follow the directions on the product label and not exceed them. Because quality and concentration differ between brands, and because little is known about safe long-term use, it is a good idea to review the product with your pharmacist before starting.
From our Cramp Bark monograph — the full record covers uses, side effects and every documented interaction.
About Fenofibrate
What Is Fenofibrate Used For?
Brand names: Tricor, Fenofibrate, Lipidil Micro, Lipidil Supra, Antara, Lofibra, Triglide, Lipidil EZ
Fenofibrate is used alongside a cholesterol-lowering diet in adults to improve abnormal lipid levels. Tricor (tablet) and fenofibrate tablets are indicated to lower LDL cholesterol (bad cholesterol), total cholesterol, triglycerides, and apolipoprotein B, and to raise HDL cholesterol (good cholesterol) in adults with primary hypercholesterolemia (high cholesterol) or mixed dyslipidemia (mixed abnormal lipid levels). They are also used to treat severe hypertriglyceridemia (very high triglycerides).
Antara and Lipofen (capsules) are indicated to reduce triglyceride levels in adults with severe hypertriglyceridemia, and to lower LDL cholesterol in adults with primary hyperlipidemia when other recommended LDL-lowering therapies cannot be used. Fenofibrate has not been shown to reduce heart attacks or cardiovascular deaths in patients with type 2 diabetes.
Most-Reported Side Effects for Fenofibrate
From FAERS, the FDA’s public side-effect reporting system (35,249 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Cramp Bark
Browse every other medication we’ve checked against Cramp Bark — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Cramp Bark against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Cramp Bark list.
Sources & How We Checked
We checked Cramp Bark against Fenofibrate in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Cramp Bark and Fenofibrate Together: Common Questions
Is it safe to take Cramp Bark with Fenofibrate?
Are Cramp Bark and Fenofibrate used for the same thing?
Does Fenofibrate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Fenofibrate and Cramp Bark?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.