Drug & supplement interaction

Dimethylglycine (dmg) + Clonazepam

Clonazepam brand names: Klonopin, Rivotril, Ceberclon.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Dimethylglycine (dmg) and Clonazepam in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Dimethylglycine (dmg) and Clonazepam

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clonazepam and Dimethylglycine (dmg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Dimethylglycine (dmg) at all — not against Clonazepam, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylglycine (dmg) safety at a glance

Dimethylglycine (d... overall Use caution Appears generally well tolerated short-term, but high-quality long-term safety data are limited.
Pregnancy Avoid Not enough safety information; best to avoid during pregnancy.
Breastfeeding Avoid No reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clonazepam and Dimethylglycine (dmg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Clonazepam’s Own FDA Label Lists

This is not an interaction — none of it involves Dimethylglycine (dmg). These are the most notable effects listed in the ADVERSE REACTIONS section of Clonazepam’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Muscle weakness Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble passing urine Worth acting on
  • Unsteadiness Worth acting on
  • Hallucinations Worth acting on
  • Confusion Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 37 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Clonazepam. Read the label on DailyMed › Dimethylglycine (dmg)’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Dimethylglycine (dmg) side to compare — that is a limit of the record, not a statement that Dimethylglycine (dmg) has no side effects.

Overlapping uses

What Clonazepam Is Prescribed For, and What Dimethylglycine (dmg) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Clonazepam is a prescription medicine with approved uses on its FDA label. Dimethylglycine (dmg) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Clonazepam is prescribed for: Clonazepam is approved to treat several types of seizures — including Lennox-Gastaut syndrome (a severe form of epilepsy), akinetic seizures (sudden loss of muscle tone), myoclonic seizures (sudden muscle jerks), and absence seizures (brief lapses of awareness) in patients who haven't responded to other medicines. It is also approved for panic disorder, with or without agoraphobia (fear of situations that might cause panic). Panic disorder involves repeated, unexpected panic attacks along with ongoing worry about having more attacks.

Dimethylglycine (dmg) has been studied for:

  • Epilepsy studied, not established Dimethylglycine (dmg) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Dimethylglycine (dmg) for epilepsy

    It is unclear if oral dimethylglycine is beneficial in patients with frequent generalized or myoclonic seizures.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Clonazepam on your own; if you are taking Dimethylglycine (dmg) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Dimethylglycine (dmg) or Clonazepam

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dimethylglycine (dmg) or Clonazepam, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clonazepam

This page covers Dimethylglycine (dmg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clonazepam page lists 206 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 158 moderate · 39 minor.

From our pharmacist’s overview on the Clonazepam page

“Clonazepam (Klonopin) slows brain activity to control seizures and panic, and most of what interacts with it pushes in one of two directions: deepening that sedation or changing how much drug is in your blood. This is a list to approach carefully.”

Reviewed by 2 · Jul 18, 2026

Open the Clonazepam interaction page

How much people look this up

Where Dimethylglycine (dmg) and Clonazepam Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylglycine (dmg)
Steady interest

#1,435 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clonazepam
Top 5%

#51 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Dimethylglycine (dmg) is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylglycine (dmg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Dimethylglycine (dmg) and Clonazepam records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dimethylglycine (dmg)

What is Dimethylglycine (dmg)?

  • Athletic performance and energy
  • Autism spectrum support
  • Immune support
  • Seizure disorders
  • General wellness and detox support

Dimethylglycine (DMG) is a substance made naturally in the body and found in small amounts in foods. It is marketed for energy, athletic performance, autism, and immune support, but solid human evidence for most of these uses is limited. It appears generally well tolerated in short-term use, but talk with your pharmacist or doctor before trying it.

Not applicable (a naturally occurring amino acid derivative) · Tablets, capsules, chewable tablets, sublingual tablets, powder

An interaction check asks whether these two react with each other — it does not ask whether Dimethylglycine (dmg) is a good idea for someone in your situation. Here is what our Dimethylglycine (dmg) record says about it on its own.

Dimethylglycine (dmg): dosing

There is no officially established or standardized dose of DMG. Products vary widely in strength and in the directions they give.The safest approach is to follow the dosing instructions on the product label and not exceed them. If you do not notice a clear benefit, there is no reason to keep taking it.

From our Dimethylglycine (dmg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylglycine (dmg) monograph & all interactions
Medication

About Clonazepam

What Is Clonazepam Used For?

Brand names: Klonopin, Rivotril, Ceberclon

Clonazepam is approved to treat several types of seizures — including Lennox-Gastaut syndrome (a severe form of epilepsy), akinetic seizures (sudden loss of muscle tone), myoclonic seizures (sudden muscle jerks), and absence seizures (brief lapses of awareness) in patients who haven't responded to other medicines.

It is also approved for panic disorder, with or without agoraphobia (fear of situations that might cause panic). Panic disorder involves repeated, unexpected panic attacks along with ongoing worry about having more attacks.

Most-Reported Side Effects for Clonazepam

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 10,473 reports
Nausea 9,818 reports
Anxiety 8,896 reports
Headache 8,763 reports
Depression 8,232 reports
See full Clonazepam drug information
Keep checking

Other Drugs & Dimethylglycine (dmg)

Browse every other medication we’ve checked against Dimethylglycine (dmg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Dimethylglycine (dmg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Dimethylglycine (dmg) list.

See the full Dimethylglycine (dmg) interactions page
See every supplement checked against Clonazepam, ranked by severity
Evidence & sources

Dimethylglycine (dmg) References

The 2 sources that drive our Dimethylglycine (dmg) monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Dimethylglycine (dmg) is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylglycine (dmg) and Clonazepam Together: Common Questions

Is it safe to take Dimethylglycine (dmg) with Clonazepam?
We do not list a known interaction between Dimethylglycine (dmg) and Clonazepam. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Dimethylglycine (dmg) and Clonazepam used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Dimethylglycine (dmg) in each. That is a conversation for your prescriber, especially if Clonazepam is being adjusted to a target.
Does Clonazepam interact with any supplements?
Yes. Clonazepam has documented interactions with 206 supplements in our database — Dimethylglycine (dmg) is not one of them. The Clonazepam interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dimethylglycine (dmg) monograph Uses, safety profile, and every drug interaction in one place Clonazepam drug information The full plain-English guide to this medication Clonazepam supplement interactions Every supplement checked against Clonazepam, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clonazepam and Dimethylglycine (dmg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.