Great Plantain + Olaparib
Olaparib brand name: Lynparza.
We found no known interaction between Great Plantain and Olaparib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Great Plantain and Olaparib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Olaparib and Great Plantain in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Great Plantain safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Olaparib
Interactions in our licensed database are recorded against drug classes, not just single drug names. Olaparib is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Great Plantain has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Olaparib’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Great Plantain Does Interact With Other Medications
Great Plantain has 2 moderate known drug interactions in our database — Olaparib isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Great Plantain
We haven’t checked that one against Great Plantain yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Great Plantain. Pick one to open its full report.
Great Plantain in Pregnancy & Breastfeeding
When used orally because it can increase uterine tone.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Olaparib
This page covers Great Plantain only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Olaparib page lists 138 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 94 moderate · 41 minor.
From our pharmacist’s overview on the Olaparib page
“Grapefruit is the first thing to drop if you take Olaparib (Lynparza). It blocks CYP3A4, the liver enzyme that clears this cancer drug, so levels can climb and side effects with them.”
Reviewed by 2 · Jul 18, 2026
Where Great Plantain and Olaparib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,031 of 1,452 supplements looked up here in the last 7 days
#1,886 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Great Plantain reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Great Plantain and Olaparib records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Great Plantain
What is Great Plantain?
- Minor wounds and skin irritation
- Insect bites and stings
- Coughs and sore throat
- Digestive upset
- Mild inflammation
Great Plantain is a common weed traditionally used on the skin for minor wounds and bites, and as a tea for coughs or stomach upset. Human evidence for most of these uses is limited, though the plant appears generally well tolerated. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have a health condition.
Plantago major · Plantaginaceae · Leaves and seeds · Tea, capsules, tinctures, topical salves and ointments, fresh crushed leaves (poultice)
An interaction check asks whether these two react with each other — it does not ask whether Great Plantain is a good idea for someone in your situation. Here is what our Great Plantain record says about it on its own.
Great Plantain: dosing
There is no well-established standardized dose for Great Plantain. Traditional use varies widely, and the amount of active compounds differs between products and plant sources.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or doctor can help you decide whether it is appropriate for you and review your other medications and health conditions first.
From our Great Plantain monograph — the full record covers uses, side effects and every documented interaction.
About Olaparib
What Is Olaparib Used For?
Brand name: Lynparza
Lynparza (olaparib) is used to treat adults with certain ovarian, fallopian tube, or primary peritoneal cancers that carry BRCA or other DNA-repair gene mutations — both as a maintenance therapy after platinum-based chemotherapy (including in combination with bevacizumab for some patients) and for recurrent disease. It is also approved for HER2-negative breast cancer with a germline BRCA mutation, both in early high-risk disease (adjuvant setting) and in metastatic disease.
Lynparza is additionally used as maintenance therapy for adults with germline BRCA-mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on first-line platinum-based chemotherapy, and for adults with certain gene-mutated metastatic castration-resistant prostate cancer — either alone (after prior enzalutamide or abiraterone) or in combination with abiraterone and prednisone or prednisolone. All uses require testing for specific genetic mutations using an FDA-approved companion diagnostic before starting treatment.
Most-Reported Side Effects for Olaparib
From FAERS, the FDA’s public side-effect reporting system (20,798 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Great Plantain
Browse every other medication we’ve checked against Great Plantain — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
2 interactions
No interaction 2,827 drugs checked — show the list
We also checked Great Plantain against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Great Plantain list.
Great Plantain References
The 3 references that drive our Great Plantain monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Adom MB, Taher M, Mutalabisin MF, et al. Chemical constituents and medical benefits of Plantago major. Biomed Pharmacother. 2017;96:348-360. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Great Plantain and Olaparib Together: Common Questions
Is it safe to take Great Plantain with Olaparib?
How was the Great Plantain and Olaparib combination checked?
Does Great Plantain interact with any other medications?
Does Olaparib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Olaparib and Great Plantain?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.