Hops - NyQuil (acetaminophen, dextromethorphan, doxylamine) Interaction
Herbal: Hops
Also Known As: Humulus lupulus, Asperge Sauvage, Common Hops, Couleuvrée, Couleuvrée Septentrionale, European Hops, Hop, Hop Strobile, Hopfenzapfen, Houblon, Lupuli Strobulus, Lupulin, Lúpulo, Pi Jiu Hua, Salsepareille Indigène, Vigne du Nord
Drug: acetaminophen, dextromethorphan, doxylamine
Brand names:
NyQuil
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
acetaminophen, dextromethorphan, doxylamine is classified as belonging to the following category: Cns Depressants
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541.
- Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
- Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
Hops Overview
Hops are the female flowers (also known as cones) of the hop plant, Humulus lupulus, and a member of the Cannabaceae family. Hops are native to Europe and are widely cultivated in many parts of the world. Hops have a variety of applications, such as for food flavoring and brewing beer. Hops extract has been used in topical medicinal preparations and as a dietary supplement.
Hops - More Interactions
Hops interacts with 841 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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