Drug & supplement interaction

Indium + Levothyroxine

Levothyroxine brand names: Euthyrox, Levothroid, Unithroid, Synthroid, Levoxyl, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Indium and Levothyroxine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Levothyroxine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Indium and Levothyroxine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levothyroxine and Indium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Indium at all — not against Levothyroxine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Indium safety at a glance

Indium overall Avoid Indium is not an essential nutrient and lacks reliable human safety or benefit data.
Pregnancy Possibly Unsafe When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many organ syst... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many organ syst... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levothyroxine and Indium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Indium and Levothyroxine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Chest pain / Shortness of breath Worth acting on Additional detail

    Indium

    “Occupational exposure to indium by inhalation can lead to potentially fatal interstitial lung disease, characterized by pulmonary alveolar proteinosis, progressing to fibrosis with or without emphysema. The disease develops slowly with shortness of breath, chest tightness and pain, dry cough, dyspnea, and deteriorating pulmonary function tests.”

    Indium · Natural Medicines adverse-effect record, reported in chronic obstructive pulmonary disease (copd).

    2 sources cited
    1. 111188. Tsao YC, Fan HY, Luo JJ. Case reports of indium lung disease in Taiwan. J Formos Med Assoc. 2021 Feb;120(2):893-8. PubMed
    2. 111189. Yang J, Zhang W, Feng J. Low serum indium levels induce expression disorders of some inflammatory factors. Int Arch Occup Environ Health. 2021 Jan;94(1):23-30. PubMed

    Levothyroxine

    Listed in the ADVERSE REACTIONS section of the FDA label for Levothyroxine. Read the label on DailyMed ›

Reported for Indium but not commonly for Levothyroxine: cough.

Effects for Levothyroxine come from the ADVERSE REACTIONS section of its FDA label; effects for Indium come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Indium in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. The effect of indium on the fetus or breast-feeding newborn is not known; however, indium compounds are thought to be toxic to many organ systems; avoid using. ...when indium (In-111) pentetreotide is used intravenously. It is not known if it can harm the fetus, or if it is excreted in breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Levothyroxine Products Have a Food Rule — Indium Should Not Break It

At least one FDA label for a product containing Levothyroxine says to take it on an empty stomach. Most supplements — Indium included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Levothyroxine on its own and move Indium to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Levothyroxine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Indium or Levothyroxine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Indium or Levothyroxine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levothyroxine

This page covers Indium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levothyroxine page lists 50 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 39 moderate · 9 minor.

From our pharmacist’s overview on the Levothyroxine page

“Levothyroxine replaces a hormone your body measures in tiny amounts, so small shifts in its blood level show up in how you feel, and I treat this list with genuine care. Nearly everything on it does one of two things: blocks the pill from being absorbed in the gut, the way everyday minerals like calcium do by binding it into complexes,…”

Reviewed by 2 · Jul 18, 2026

Open the Levothyroxine interaction page

One more smart check

Taking Indium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 53 real supplement products containing Indium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Indium. Even though Indium itself has no known interaction with Levothyroxine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Indium and Levothyroxine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Indium
Top half

#644 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levothyroxine
Top 10

#2 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Indium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Indium and Levothyroxine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Indium

What is Indium?

  • Anti-aging
  • Boosting energy
  • Supporting hormone or gland function
  • General 'wellness' or trace mineral supplementation

Indium is a metallic chemical element sometimes sold as a liquid 'trace mineral' supplement with bold anti-aging and energy claims, but it is not a recognized essential nutrient and there is no reliable human evidence that it offers any health benefit. Because safety data are very limited and it is a heavy metal, most people should avoid it and talk with a pharmacist or doctor first.

Not a plant; a chemical element (indium) sold as a mineral supplement · Liquid 'indium sulfate' drops, sometimes capsules

An interaction check asks whether these two react with each other — it does not ask whether Indium is a good idea for someone in your situation. Here is what our Indium record says about it on its own.

Indium: dosing

There is no established or recommended dose for indium, because it is not an essential nutrient and has no proven benefit. Products that contain it are not standardized, and label amounts vary.We do not recommend a specific dose. In general, the safest choice is to avoid it.

From our Indium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Indium monograph & all interactions
Medication

About Levothyroxine

What Is Levothyroxine Used For?

Brand names: Euthyrox, Levothroid, Unithroid, Synthroid, Levoxyl, Levo-T, Eltroxin, Estre, Levothyroxine, Novothyrox, Levolet

Levothyroxine replaces or supplements the thyroid hormone your body isn't making enough of. It's used for hypothyroidism — an underactive thyroid — in adults, children, and even newborns, whether the cause is the thyroid gland itself, the pituitary gland, or the hypothalamus in the brain.

It's also used alongside surgery and radioiodine treatment in people with certain types of thyroid cancer, to help suppress the hormone that can stimulate cancer growth. It is not meant for weight loss, treating benign thyroid nodules in people who have enough iodine, or for hypothyroidism during recovery from a temporary condition called subacute thyroiditis.

See full Levothyroxine drug information
Keep checking

Other Drugs & Indium

Browse every other medication we’ve checked against Indium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Indium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Indium list.

See the full Indium interactions page
See every supplement checked against Levothyroxine, ranked by severity
Evidence & sources

Indium References

The 5 references that drive our Indium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Miyaki K, Hosoda K, Hirata M, et al. Biological monitoring of indium by means of graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds. J Occup Health 2003;45:228-30. PubMed
  2. Indium. Material Safety Data Sheet. Science Lab, October 2005.
  3. Indium In-111 pentetreotide injection (OctreoScan) Package Insert. Curium US LLC, Maryland Heights, MO. 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=93d8f3b2-1216-41dc-a63d-0e812b33891d. Accessed April 25, 2020.
  4. Tsao YC, Fan HY, Luo JJ. Case reports of indium lung disease in Taiwan. J Formos Med Assoc. 2021 Feb;120(2):893-8. PubMed
  5. Yang J, Zhang W, Feng J. Low serum indium levels induce expression disorders of some inflammatory factors. Int Arch Occup Environ Health. 2021 Jan;94(1):23-30. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Indium and Levothyroxine Together: Common Questions

Is it safe to take Indium with Levothyroxine?
We do not list a known interaction between Indium and Levothyroxine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Indium and Levothyroxine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Indium and Levothyroxine at the same time of day?
At least one FDA label for a product containing Levothyroxine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Levothyroxine on its own and move Indium to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Levothyroxine interact with any supplements?
Yes. Levothyroxine has documented interactions with 50 supplements in our database — Indium is not one of them. The Levothyroxine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Indium monograph Uses, safety profile, and every drug interaction in one place Levothyroxine drug information The full plain-English guide to this medication Levothyroxine supplement interactions Every supplement checked against Levothyroxine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levothyroxine and Indium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.