Drug & supplement interaction

Isatis + Olsalazine Sodium

Olsalazine Sodium brand name: Dipentum.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Isatis and Olsalazine Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Isatis and Olsalazine Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Olsalazine Sodium and Isatis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Isatis at all — not against Olsalazine Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Isatis safety at a glance

Isatis overall Use caution Generally used short-term in traditional medicine, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is no reliable safety data, so avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Olsalazine Sodium and Isatis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Olsalazine Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Isatis. These are the most notable effects listed in the ADVERSE REACTIONS section of Olsalazine Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Kidney stones Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Dehydration Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Wheezing Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 46 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Olsalazine Sodium. Read the label on DailyMed › Isatis’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Isatis side to compare — that is a limit of the record, not a statement that Isatis has no side effects.

Overlapping uses

What Olsalazine Sodium Is Prescribed For, and What Isatis Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Olsalazine Sodium is a prescription medicine with approved uses on its FDA label. Isatis is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Olsalazine Sodium is prescribed for: Dipentum (olsalazine) is used to keep ulcerative colitis in remission — meaning it helps prevent the disease from flaring up after it has been brought under control. It is specifically approved for adults who are intolerant of sulfasalazine, another medication commonly used for ulcerative colitis.

Isatis has been studied for:

  • Diarrhea studied, not established Isatis has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Isatis for diarrhea

    Although there is interest in using oral isatis for diarrhea, there is insufficient reliable information about the clinical effects of isatis for this condition.

  • Ulcerative colitis studied, not established Isatis has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Isatis for ulcerative colitis

    Although there is interest in using oral isatis for ulcerative colitis, there is insufficient reliable information about the clinical effects of isatis for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Olsalazine Sodium on your own; if you are taking Isatis for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Olsalazine Sodium

This page covers Isatis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Olsalazine Sodium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Olsalazine Sodium page

“Olsalazine sodium (Dipentum) treats ulcerative colitis, and it only works if enough of the drug travels intact to the colon, so anything that binds it or interferes with its passage through the gut deserves real attention. All 17 supplement interactions on file involve absorption, and one carries a major rating: activated charcoal, whi…”

Reviewed by 2 · Jul 18, 2026

Open the Olsalazine Sodium interaction page

One more smart check

Taking Isatis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 413 real supplement products containing Isatis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Isatis. Even though Isatis itself has no known interaction with Olsalazine Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Isatis and Olsalazine Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Isatis
Top 25%

#305 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Olsalazine Sodium
Steady interest

#2,609 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Isatis is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Isatis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Isatis and Olsalazine Sodium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Isatis

What is Isatis?

  • Colds and flu-like illness
  • Sore throat
  • Fever
  • Immune support
  • Antiviral and antimicrobial support

Isatis is a plant long used in traditional Chinese medicine, mainly for sore throats, fevers, and colds. Modern evidence in people is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Isatis tinctoria · Brassicaceae · Root (Ban Lan Gen) and leaf (Da Qing Ye) · Capsules, tablets, granules, powders, teas, and tinctures

An interaction check asks whether these two react with each other — it does not ask whether Isatis is a good idea for someone in your situation. Here is what our Isatis record says about it on its own.

Isatis: dosing

There is no well-established standard dose for Isatis. Traditional preparations and modern products vary widely in strength and form.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount. A pharmacist or qualified healthcare provider can help you decide whether it is appropriate for you and review your other medicines and health conditions first.

From our Isatis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Isatis monograph & all interactions
Medication

About Olsalazine

What Is Olsalazine Used For?

Brand name: Dipentum

Dipentum (olsalazine) is used to keep ulcerative colitis in remission — meaning it helps prevent the disease from flaring up after it has been brought under control. It is specifically approved for adults who are intolerant of sulfasalazine, another medication commonly used for ulcerative colitis.

Most-Reported Side Effects for Olsalazine Sodium

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Colitis ulcerative 19 reports
Diarrhea 14 reports
Fatigue 9 reports
Pain in extremity 7 reports
Pruritus 7 reports
See full Olsalazine drug information
Keep checking

Other Drugs & Isatis

Browse every other medication we’ve checked against Isatis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Isatis References

The 3 sources that drive our Isatis monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Isatis is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source
  3. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Isatis and Olsalazine Sodium Together: Common Questions

Is it safe to take Isatis with Olsalazine Sodium?
We do not list a known interaction between Isatis and Olsalazine Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Isatis and Olsalazine Sodium used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Isatis in each. That is a conversation for your prescriber, especially if Olsalazine Sodium is being adjusted to a target.
Does Olsalazine Sodium interact with any supplements?
Yes. Olsalazine Sodium has documented interactions with 17 supplements in our database — Isatis is not one of them. The Olsalazine Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Olsalazine Sodium and Isatis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.