Drug & supplement interaction

Javanese Turmeric + Tafenoquine

Tafenoquine brand names: Krintafel, Arakoda.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Javanese Turmeric and Tafenoquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tafenoquine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Javanese Turmeric and Tafenoquine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tafenoquine and Javanese Turmeric in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Javanese Turmeric safety at a glance

Javanese Turmeric overall Use caution Generally well tolerated in food-like amounts, but human safety data for concentrated supplements are limited.
Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tafenoquine and Javanese Turmeric? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tafenoquine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tafenoquine is filed under a single classification — oral drugs. Javanese Turmeric has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Tafenoquine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Javanese Turmeric Does Interact With Other Medications

Javanese Turmeric has 2 moderate known drug interactions in our database — Tafenoquine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Tafenoquine)
Taking anything else?

Check Another of Your Medications Against Javanese Turmeric

Covers the 2,830 medications we’ve checked against Javanese Turmeric. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Javanese Turmeric and Tafenoquine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 20.0% of FDA reports for Tafenoquine Additional detail

    Javanese Turmeric

    “Orally, Javanese turmeric can cause gastric irritation and nausea when used in large amounts or for prolonged periods of time (2,8).”

    Javanese Turmeric · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 8. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.

    Tafenoquine

    Listed in the ADVERSE REACTIONS section of the FDA label for Tafenoquine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Javanese Turmeric but not commonly for Tafenoquine: stomach upset.

Effects for Tafenoquine come from the ADVERSE REACTIONS section of its FDA label; effects for Javanese Turmeric come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 70 voluntary FDA FAERS reports for Tafenoquine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Tafenoquine Products Have a Food Rule — Javanese Turmeric Should Not Break It

At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Javanese Turmeric on an empty stomach out of habit, keep them separate — and take Tafenoquine with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tafenoquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 ) Regimen Name Timing Dosage Loading regimen For each of the 3 days before travel to a malarious area 200 mg (2 of the 100 mg tablets) once daily for 3 days Maintenance regimen While in the malarious area 200 mg (2 of the 100 mg tablets) once weekly – start 7 days after the last loading regimen dose Terminal prophylaxis regimen In the week following exit from the malarious area 200 mg (2 of

From the Dosage and Administration section of the FDA label we read for Tafenoquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tafenoquine

This page covers Javanese Turmeric only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tafenoquine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Tafenoquine page

“Tafenoquine (Krintafel, Arakoda) protects against malaria, including the relapsing kind that hides in the liver, and every supplement known to interact with it threatens the same thing, how much of the pill actually reaches your blood. That deserves genuine care, since a partly absorbed antimalarial can let parasites survive and resurf…”

Reviewed by 2 · Jul 18, 2026

Open the Tafenoquine interaction page

One more smart check

Taking Javanese Turmeric as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Javanese Turmeric, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Javanese Turmeric. Even though Javanese Turmeric itself has no known interaction with Tafenoquine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Javanese Turmeric and Tafenoquine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Javanese Turmeric
Steady interest

#1,015 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tafenoquine
Steady interest

#2,062 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Javanese Turmeric reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Javanese Turmeric and Tafenoquine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Javanese Turmeric

What is Javanese Turmeric?

  • Digestive upset and bloating
  • Liver and gallbladder support
  • Loss of appetite
  • Joint and inflammation complaints
  • General wellness tonic

Javanese turmeric (Curcuma zanthorrhiza), known in Indonesia as temulawak, is a ginger-family root traditionally used for digestive and liver complaints. Early lab and animal studies are interesting, but strong human evidence is limited, so it should be viewed as a traditional remedy rather than a proven treatment. Talk to a pharmacist or doctor before using it, especially if you have a health condition or take medications.

Curcuma zanthorrhiza · Zingiberaceae · Rhizome (root) · Capsules, tablets, powder, dried root, tea, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Javanese Turmeric is a good idea for someone in your situation. Here is what our Javanese Turmeric record says about it on its own.

Javanese Turmeric: dosing

There is no well-established standardized dose for Javanese turmeric. Products vary widely in strength and form, and the active compounds are absorbed differently from one preparation to another.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Javanese Turmeric monograph — the full record covers uses, side effects and every documented interaction.

Read the full Javanese Turmeric monograph & all interactions
Medication

About Tafenoquine

What Is Tafenoquine Used For?

Brand names: Krintafel, Arakoda

Tafenoquine is used for two distinct purposes depending on the product. Arakoda and Kodatef are used for malaria prophylaxis — that is, preventing malaria in adults 18 and older who are traveling to or living in areas where malaria is present.

Krintafel is used for the radical cure of Plasmodium vivax malaria — meaning it prevents the malaria parasite from coming back (relapsing) in patients 16 and older who are already being treated with chloroquine for an active P. vivax infection. Krintafel is not used to treat an active malaria attack on its own, and it should only be used alongside chloroquine, not other antimalarials.

Most-Reported Side Effects for Tafenoquine

From FAERS, the FDA’s public side-effect reporting system (70 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Depression 20 reports
Anxiety 18 reports
Post-traumatic stress disorder 15 reports
Anger 14 reports
Nausea 14 reports
See full Tafenoquine drug information
Keep checking

Other Drugs & Javanese Turmeric

Browse every other medication we’ve checked against Javanese Turmeric — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Javanese Turmeric against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Javanese Turmeric list.

See the full Javanese Turmeric interactions page
See every supplement checked against Tafenoquine, ranked by severity
Evidence & sources

Javanese Turmeric References

The 3 references that drive our Javanese Turmeric monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Rusdiana T, Mardhiani YD, Putriana NA, et al. The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies. Pharm Biol. 2021;59(1):639-646.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Javanese Turmeric and Tafenoquine Together: Common Questions

Is it safe to take Javanese Turmeric with Tafenoquine?
We do not list a known interaction between Javanese Turmeric and Tafenoquine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Javanese Turmeric and Tafenoquine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Javanese Turmeric and Tafenoquine at the same time of day?
At least one FDA label for a product containing Tafenoquine says to take it with food. If you take Javanese Turmeric on an empty stomach out of habit, keep them separate and take Tafenoquine with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Tafenoquine products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Javanese Turmeric and Tafenoquine combination checked?
Interactions in our licensed database are recorded against drug classes. Tafenoquine is filed under 1 classification, and Javanese Turmeric has documented interactions with 1 drug class — none of Tafenoquine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Javanese Turmeric interact with any other medications?
Yes. Javanese Turmeric has 2 documented drug interactions in our database — Tafenoquine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tafenoquine interact with any supplements?
Yes. Tafenoquine has documented interactions with 17 supplements in our database — Javanese Turmeric is not one of them. The Tafenoquine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Javanese Turmeric monograph Uses, safety profile, and every drug interaction in one place Tafenoquine drug information The full plain-English guide to this medication Tafenoquine supplement interactions Every supplement checked against Tafenoquine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tafenoquine and Javanese Turmeric?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.