Drug & supplement interaction

Kamala + Upadacitinib Hemihydrate

Upadacitinib Hemihydrate brand name: Rinvoq.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Kamala and Upadacitinib Hemihydrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Kamala and Upadacitinib Hemihydrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Upadacitinib Hemihydrate and Kamala in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Kamala at all — not against Upadacitinib Hemihydrate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kamala safety at a glance

Kamala overall Use caution Limited modern safety data and a known tendency to cause strong digestive effects.
Pregnancy Avoid Traditionally used to stimulate the uterus and not considered safe in pregnancy.
Breastfeeding Avoid No reliable safety data during breastfeeding, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Upadacitinib Hemihydrate and Kamala? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Upadacitinib Hemihydrate’s Own FDA Label Lists

This is not an interaction — none of it involves Kamala. These are the most notable effects listed in the ADVERSE REACTIONS section of Upadacitinib Hemihydrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on
  • Low blood sugar Worth acting on
  • Blood clots Worth acting on
  • Anemia Worth acting on
  • A low white blood cell count Worth acting on
  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Acne
  • Weight gain

Showing the 10 most notable of 22 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Upadacitinib Hemihydrate. Read the label on DailyMed › Kamala’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Kamala side to compare — that is a limit of the record, not a statement that Kamala has no side effects.

Everything else you take

See Every Supplement That Interacts With Upadacitinib Hemihydrate

This page covers Kamala only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Upadacitinib Hemihydrate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Upadacitinib Hemihydrate page

“Grapefruit is the pairing I would want anyone on Rinvoq (upadacitinib) to know about first. The drug is cleared by a liver enzyme called CYP3A4, and grapefruit blocks that enzyme, letting blood levels climb, which matters for a medicine that already dials down the immune system.”

Reviewed by 2 · Jul 18, 2026

Open the Upadacitinib Hemihydrate interaction page

One more smart check

Taking Kamala as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Kamala, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kamala. Even though Kamala itself has no known interaction with Upadacitinib Hemihydrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kamala and Upadacitinib Hemihydrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kamala
Steady interest

#1,201 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Upadacitinib Hemihydrate
Steady interest

#1,575 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Kamala and Upadacitinib Hemihydrate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Kamala

What is Kamala?

  • Intestinal worms (especially tapeworm)
  • Skin conditions and parasites
  • Constipation/laxative effect
  • Wound care (traditional)
  • Use as a natural orange-red dye

Kamala is a red powder from the fruit of the Mallotus philippensis tree, used in traditional medicine mainly to expel intestinal worms and as a dye. Modern human evidence for its safety and effectiveness is very limited, and it can cause significant digestive upset, so it should only be used under professional guidance, if at all.

Mallotus philippensis · Euphorbiaceae · Red powder (glands and hairs) from the surface of the fruit; sometimes bark and leaves · Powder, capsules, traditional preparations; also used historically as a dye

An interaction check asks whether these two react with each other — it does not ask whether Kamala is a good idea for someone in your situation. Here is what our Kamala record says about it on its own.

Kamala: dosing

There is no well-established, standardized dose of Kamala supported by modern clinical research. Do not exceed the recommended amount, and avoid using it for self-treatment of worm infections without medical guidance, since safer and better-studied options are available.

From our Kamala monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kamala monograph & all interactions
Medication

About Upadacitinib

What Is Upadacitinib Used For?

Brand name: Rinvoq

Upadacitinib is approved for adults and some children with moderate-to-severe inflammatory conditions when other treatments haven't worked well enough. It targets overactive immune signaling that drives these diseases.

Conditions it treats include:

  • Rheumatoid arthritis (RA) — in adults who didn't respond to TNF blocker medications
  • Psoriatic arthritis — in adults and children 2 years and older who didn't respond to TNF blockers
  • Atopic dermatitis (eczema) — in people 12 and older whose disease isn't controlled by other systemic therapies
  • Ulcerative colitis — in adults who didn't respond to TNF blockers or other approved therapies
  • Crohn's disease — in adults who didn't respond to TNF blockers or other approved therapies

See full Upadacitinib drug information
Keep checking

Other Drugs & Kamala

Browse every other medication we’ve checked against Kamala — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Kamala against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Kamala list.

See the full Kamala interactions page
See every supplement checked against Upadacitinib Hemihydrate, ranked by severity
Sources

Sources & How We Checked

We checked Kamala against Upadacitinib Hemihydrate in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Kamala monograph › Uses, safety, and every drug interaction in one place Upadacitinib Hemihydrate supplement interactions › Every supplement checked against Upadacitinib Hemihydrate, ranked by severity Upadacitinib drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Kamala and Upadacitinib Hemihydrate Together: Common Questions

Is it safe to take Kamala with Upadacitinib Hemihydrate?
We do not list a known interaction between Kamala and Upadacitinib Hemihydrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Upadacitinib Hemihydrate interact with any supplements?
Yes. Upadacitinib Hemihydrate has documented interactions with 138 supplements in our database — Kamala is not one of them. The Upadacitinib Hemihydrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Upadacitinib Hemihydrate and Kamala?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.