Kaolin + Clindamycin, Adapalene, Benzoyl Peroxide
Clindamycin, Adapalene, Benzoyl Peroxide brand name: Cabtreo.
Kaolin has a moderate interaction with Clindamycin, Adapalene, Benzoyl Peroxide. Kaolin appears to slow the rate of clindamycin absorption, but doesn't affect the extent of absorption.
Read the full interaction reportKaolin and Clindamycin, Adapalene, Benzoyl Peroxide
Here is the interaction we found between these two, with the evidence behind it.
CLINDAMYCIN (Cleocin)
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the good news about Cabtreo (clindamycin, adapalene, and benzoyl peroxide): it's a topical gel you smooth onto your skin, not something you swallow. The interaction on file describes kaolin binding to oral clindamycin in the gut and slowing how fast it's absorbed. Since you're applying this product to your face, kaolin taken by mouth for diarrhea really shouldn't cross paths with it in any meaningful way.
So in practical terms, using a kaolin antidiarrheal while treating your acne with Cabtreo isn't a combination I'd lose sleep over. If you're ever prescribed clindamycin as a pill or capsule down the road, that's a different story, so keep it in mind. As always, run your specific routine by your pharmacist if you have any doubts.
- Albert KS, et al. Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin. J Pharm Sci 1978 67:1579-82.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Kaolin Also Interacts With Other Medications
Kaolin has 6 moderate known drug interactions in our database — the Clindamycin, Adapalene, Benzoyl Peroxide one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Kaolin
We haven’t checked that one against Kaolin yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Kaolin. Pick one to open its full report.
See Every Supplement That Interacts With Clindamycin, Adapalene, Benzoyl Peroxide
This page covers Kaolin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clindamycin, Adapalene, Benzoyl Peroxide page lists 4 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).
By severity: 3 moderate · 1 minor.
From our pharmacist’s overview on the Clindamycin, Adapalene, Benzoyl Peroxide page
“Someone using Cabtreo (clindamycin, adapalene, and benzoyl peroxide) for acne is usually more worried about dryness and peeling than about supplement clashes, and the list here backs that up: only four ingredients on file, three moderate and one minor, nothing major. The main theme is absorption through the skin.”
Reviewed by 2 · Jul 18, 2026
Open the Clindamycin, Adapalene, Benzoyl Peroxide interaction page
Where Kaolin and Clindamycin, Adapalene, Benzoyl Peroxide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#787 of 1,452 supplements looked up here in the last 7 days
#949 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Kaolin
What is Kaolin?
- Diarrhea
- Upset stomach and nausea
- Skincare and facial masks
- Soothing minor skin irritation
- Excessive salivation (traditional)
Kaolin is a soft, white clay mineral that has long been used in antidiarrheal products and skincare because it absorbs water and binds substances in the gut. Older diarrhea products often combined it with pectin, but modern guidelines favor rehydration and other treatments, and high-quality evidence for kaolin alone is limited. It is generally considered low-risk for short-term use, but check with your pharmacist or doctor before use, especially during pregnancy or breastfeeding.
Other Drugs & Kaolin
Browse every other medication we’ve checked against Kaolin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
6 interactions
No interaction 2,823 drugs checked — show the list
We also checked Kaolin against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Ibuprofen ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Tadalafil ›
- Metformin ›
- Sumatriptan ›
- Prednisone ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Levothyroxine, Liothyronine ›
- Amphetamine ›
- Methotrexate ›
- Propranolol ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,823 medications checked with no known interaction — see the full Kaolin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Kaolin and Clindamycin, Adapalene, Benzoyl Peroxide Together: Common Questions
Can you take Kaolin with Clindamycin, Adapalene, Benzoyl Peroxide?
How serious is the Kaolin and Clindamycin, Adapalene, Benzoyl Peroxide interaction?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.