Knotweed + Sofosbuvir, Velpatasvir, Voxilaprevir
Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.
We found no known interaction between Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to.
Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Knotweed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Knotweed at all — not against Sofosbuvir, Velpatasvir, Voxilaprevir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Knotweed safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Knotweed Should Not Break It
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Knotweed on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir
This page covers Knotweed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 130 moderate · 40 minor.
From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page
“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”
Reviewed by 2 · Jul 18, 2026
Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page
Taking Knotweed as Part of a Dietary Supplement Product? Check It for Interactions
We hold 46 real supplement products containing Knotweed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Knotweed. Even though Knotweed itself has no known interaction with Sofosbuvir, Velpatasvir, Voxilaprevir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,189 of 1,452 supplements looked up here in the last 7 days
#1,140 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Knotweed reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Knotweed
What is Knotweed?
- Source of resveratrol
- Heart and circulation support
- Lyme disease support (traditional/herbalist use)
- Inflammation
- Traditional Chinese medicine remedies
Japanese knotweed (Polygonum cuspidatum) is an herb best known as a natural source of resveratrol and emodin, and it is used in traditional Chinese medicine and by some herbalists. Human evidence for most modern health claims is limited, and it can cause digestive upset, so talk with your pharmacist or doctor before using it.
Polygonum cuspidatum · Polygonaceae · Roots and rhizomes (most common); also leaves and stems · Capsules, tablets, powdered root extract, tinctures, teas
An interaction check asks whether these two react with each other — it does not ask whether Knotweed is a good idea for someone in your situation. Here is what our Knotweed record says about it on its own.
Knotweed: dosing
There is no official, well-established dose for knotweed. The right amount depends on the product, how it is prepared, and how much resveratrol or other active compound it contains.Because extracts vary widely in strength, the safest approach is to follow the directions on the product label and not exceed them. A pharmacist or doctor can help you decide whether knotweed is appropriate for you and what amount may be reasonable. Choose products from reputable companies that test for quality and clearly list the species used.
From our Knotweed monograph — the full record covers uses, side effects and every documented interaction.
About Sofosbuvir, Velpatasvir, and Voxilaprevir
What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?
Brand name: Vosevi
Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults without cirrhosis (liver scarring) or with compensated cirrhosis (mild liver scarring, Child-Pugh A). It is specifically for people who have already tried an HCV treatment that did not fully work.
Vosevi is approved for adults with HCV genotypes 1, 2, 3, 4, 5, or 6 who were previously treated with a regimen containing an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who were previously treated with sofosbuvir without an NS5A inhibitor. Note: Vosevi has not been shown to offer additional benefit over sofosbuvir/velpatasvir for adults with genotype 1b, 2, 4, 5, or 6 who received sofosbuvir without an NS5A inhibitor.
Other Drugs & Knotweed
Browse every other medication we’ve checked against Knotweed — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Knotweed against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Abemaciclib ›
- Testosterone ›
- Ivermectin ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Rosuvastatin ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Tadalafil ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Prednisone ›
- Semaglutide ›
- Metformin ›
- Propranolol ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Methotrexate ›
- Isotretinoin ›
- Amoxicillin ›
- Lisinopril ›
- Amlodipine Besylate ›
- Amphetamine ›
- Bupropion ›
- Bendamustine ›
- Fluoxetine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Clonazepam ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Buspirone ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Knotweed list.
Knotweed References
The 1 references that drive our Knotweed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gonzalez Begne M, Yslas N, Reyes E, et al. Clinical effect of a Mexican sanguinaria (Polygonum aviculare L.) on gingivitis. J Ethnopharmacol 2001;74:45-51..
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions
Is it safe to take Knotweed with Sofosbuvir, Velpatasvir, Voxilaprevir?
Should I take Knotweed and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.