Koch's Glycoside + Linaclotide
Linaclotide brand name: Linzess.
We found no known interaction between Koch's Glycoside and Linaclotide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Linaclotide states a food rule worth keeping to.
Koch's Glycoside and Linaclotide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Linaclotide and Koch's Glycoside in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Koch's Glycoside at all — not against Linaclotide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Koch's Glycoside safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Linaclotide Products Have a Food Rule — Koch's Glycoside Should Not Break It
At least one FDA label for a product containing Linaclotide says to take it on an empty stomach. Most supplements — Koch's Glycoside included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Linaclotide on its own and move Koch's Glycoside to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Linaclotide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Preparation and Administration Instructions • Take LINZESS on an empty stomach, at least 30 minutes prior to a meal at approximately the same time each day.
From the Dosage and Administration section of the FDA label we read for Linaclotide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
Questions About Koch's Glycoside or Linaclotide
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Koch's Glycoside or Linaclotide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Linaclotide
This page covers Koch's Glycoside only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Linaclotide page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Linaclotide page
“Linaclotide (Linzess) treats IBS with constipation by acting inside the intestine itself, so the capsule's contents have to reach the gut unbound to do their job. That is exactly what the 17 supplements on this page can interfere with, and I would read the list with genuine care.”
Reviewed by 2 · Jul 18, 2026
Where Koch's Glycoside and Linaclotide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,296 of 1,452 supplements looked up here in the last 7 days
#1,480 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Koch's Glycoside is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Koch's Glycoside reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Koch's Glycoside and Linaclotide records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Koch's Glycoside
What is Koch's Glycoside?
"Koch's Glycoside" is not a recognized dietary supplement, herb, or established medical compound, and there is no reliable information available about its source, safety, or effects. The name may be a confusion with discredited historical "cancer cures" (such as William F. Koch's controversial "glyoxylide") rather than a true plant glycoside. Because nothing trustworthy is known about it, we cannot recommend using it, and you should speak with a pharmacist or doctor before trying any product sold under this name.
An interaction check asks whether these two react with each other — it does not ask whether Koch's Glycoside is a good idea for someone in your situation. Here is what our Koch's Glycoside record says about it on its own.
Koch's Glycoside: dosing
There is no established or safe dose for Koch's Glycoside. No standardized preparation exists, and no health authority provides dosing guidance for it.We cannot recommend any amount. If you are considering a product sold under this name, bring the actual label and ingredient list to a pharmacist or doctor so they can help you understand what you would actually be taking.
From our Koch's Glycoside monograph — the full record covers uses, side effects and every documented interaction.
About Linaclotide
What Is Linaclotide Used For?
Brand name: Linzess
Linzess (linaclotide) treats three related conditions that cause difficult, infrequent bowel movements. In adults, it is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC — ongoing constipation with no identified cause). In children ages 7 and older, Linzess is approved for IBS-C. In children ages 2 and older, Linzess is approved for functional constipation (FC).
Most-Reported Side Effects for Linaclotide
From FAERS, the FDA’s public side-effect reporting system (26,525 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Koch's Glycoside
Browse every other medication we’ve checked against Koch's Glycoside — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Koch's Glycoside against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Koch's Glycoside list.
Koch's Glycoside References
The 4 sources that drive our Koch's Glycoside monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Koch's Glycoside is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
- Herbal Supplements — MedlinePlus Source
- Health Fraud Scams — U.S. Food and Drug Administration (FDA) Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Koch's Glycoside and Linaclotide Together: Common Questions
Is it safe to take Koch's Glycoside with Linaclotide?
Should I take Koch's Glycoside and Linaclotide at the same time of day?
Does Linaclotide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Linaclotide and Koch's Glycoside?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.