Drug & supplement interaction

Labdanum + Voclosporin

Voclosporin brand name: Lupkynis.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Labdanum and Voclosporin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Voclosporin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Labdanum and Voclosporin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voclosporin and Labdanum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Labdanum at all — not against Voclosporin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Labdanum safety at a glance

Labdanum overall Use caution Generally used topically or for fragrance; safety as an internal supplement is not well studied.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voclosporin and Labdanum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Labdanum and Voclosporin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Nausea reported in 7.2% of FDA reports for Voclosporin Additional detail

    Labdanum

    “There is currently a limited amount of information on the adverse effects of labdanum. Orally, labdanum has been reported to cause nausea and stomach upset. Topically, labdanum has been reported to cause contact dermatitis.”

    Labdanum · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 98408. Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71. PubMed
    2. 98406. García-González JJ, Crespo V, Barber D, et al. Cistus ladanifer contact dermatitis. Contact Dermatitis 2001;45(4):238.
    3. 98407. English JSC, Cronin E. Allergic contact dermatitis from Cistus creticus. Contact Dermatitis 1988;18(2):123.

    “Orally, labdanum has been reported to cause nausea and stomach upset in one clinical trial.”

    Labdanum · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 98408. Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71. PubMed

    Voclosporin

    Listed in the ADVERSE REACTIONS section of the FDA label for Voclosporin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Labdanum but not commonly for Voclosporin: a skin rash.

Effects for Voclosporin come from the ADVERSE REACTIONS section of its FDA label; effects for Labdanum come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 8,444 voluntary FDA FAERS reports for Voclosporin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Voclosporin Products Have a Food Rule — Labdanum Should Not Break It

At least one FDA label for a product containing Voclosporin says to take it on an empty stomach. Most supplements — Labdanum included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Voclosporin on its own and move Labdanum to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Voclosporin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Administration : LUPKYNIS must be swallowed whole on an empty stomach.

From the Dosage and Administration section of the FDA label we read for Voclosporin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Voclosporin

This page covers Labdanum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voclosporin page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Cesium (major).

By severity: 10 major · 101 moderate · 41 minor.

Open the Voclosporin interaction page

One more smart check

Taking Labdanum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Labdanum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Labdanum. Even though Labdanum itself has no known interaction with Voclosporin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Labdanum and Voclosporin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Labdanum
Steady interest

#1,124 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voclosporin
Top 25%

#667 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Labdanum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Labdanum and Voclosporin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Labdanum

What is Labdanum?

  • Fragrance and perfumery
  • Skin care
  • Incense and aromatherapy
  • Traditional wound and skin remedies
  • Relaxation and stress relief

Labdanum is a sticky, fragrant resin from the rockrose plant (Cistus ladanifer) that is used mainly in perfumes, incense, and aromatherapy. There is very little high-quality human research to support any health or medicinal use, so it should be viewed as a scent and cosmetic ingredient rather than a proven remedy.

Cistus ladanifer · Cistaceae · Sticky resin (oleoresin) and essential oil from the leaves and stems · Essential oil, absolute, resin (used in perfumes and incense), and occasionally in skin-care products

An interaction check asks whether these two react with each other — it does not ask whether Labdanum is a good idea for someone in your situation. Here is what our Labdanum record says about it on its own.

Labdanum: dosing

There is no established or standardized medicinal dose for labdanum. It is not commonly sold as an oral supplement, and reliable human dosing information does not exist.If you use a labdanum essential oil or skin product, follow the directions on the label and dilute essential oils as instructed.

From our Labdanum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Labdanum monograph & all interactions
Medication

About Voclosporin

What Is Voclosporin Used For?

Brand name: Lupkynis

Voclosporin, sold as the capsule Lupkynis, treats active lupus nephritis in adults. This is kidney inflammation caused by lupus.

It is always used together with a background immunosuppressive regimen, not on its own. Its safety and effectiveness have not been established with cyclophosphamide, so that combination is not recommended.

Most-Reported Side Effects for Voclosporin

From FAERS, the FDA’s public side-effect reporting system (8,634 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Therapy interrupted 964 reports
Hypertension 719 reports
Headache 684 reports
Nausea 633 reports
Diarrhea 536 reports
See full Voclosporin drug information
Keep checking

Other Drugs & Labdanum

Browse every other medication we’ve checked against Labdanum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Labdanum References

The 3 references that drive our Labdanum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. García-González JJ, Crespo V, Barber D, et al. Cistus ladanifer contact dermatitis. Contact Dermatitis 2001;45(4):238.
  2. English JSC, Cronin E. Allergic contact dermatitis from Cistus creticus. Contact Dermatitis 1988;18(2):123.
  3. Kalus U, Grigorov A, Kadecki O, et al. Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. A prospective, randomised, placebo-controlled clinical study. Antiviral Res 2009;84(3):267-71. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Labdanum and Voclosporin Together: Common Questions

Is it safe to take Labdanum with Voclosporin?
We do not list a known interaction between Labdanum and Voclosporin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Labdanum and Voclosporin have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Labdanum and Voclosporin at the same time of day?
At least one FDA label for a product containing Voclosporin says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Voclosporin on its own and move Labdanum to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Voclosporin interact with any supplements?
Yes. Voclosporin has documented interactions with 152 supplements in our database — Labdanum is not one of them. The Voclosporin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Voclosporin and Labdanum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.