Lotus - Aspirin, Butalbital, Caffeine, Codeine Phosphate Interaction
Herbal: Lotus
Also Known As: Nelumbo nucifera, Bean of India, Blue Lotus, Chinese Water Lily, East Indian Lotus, He Ye, Indian Lotus, Kamal, Lian Fang, Lian Xu, Lian Zi, Lian Zi Xin, Lotier, Loto, Lotus Bleu, Lotus d'Égypte, Lotus des Indes, Lotus d'Orient, Lotus Sacré, Oriental Lotus, Padma, Padmoj, Sacr
Drug: Aspirin, Butalbital, Caffeine, Codeine Phosphate
Brand names:
Fiorinal w/ Codeine
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Aspirin, Butalbital, Caffeine, Codeine Phosphate is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, concurrent use of lotus with other antiplatelet drugs might reduce platelet aggregation and increase the risk of bleeding.
Neferine and isoliensinine, constituents of lotus, have been shown to inhibit platelet aggregation, in vitro. These constituents can inhibit the production of pro-aggregating factors like prostaglandins.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Yu, J. and Hu, W. S. [Effects of neferine on platelet aggregation in rabbits]. Yao Xue.Xue.Bao. 1997;32(1):1-4.
- Yang, J. and Zhou, K. NMR spectroscopic analysis of neferine and isoliensinine. Magn Reson.Chem 2004;42(11):994-997.
Lotus Overview
Nelumbo nucifera, also commonly known as the sacred lotus or Indian lotus, is a species of aquatic flowering plant in the water lily family (Nymphaeaceae). It is native to Asia and is widely cultivated for its flowers and for use in traditional medicine. The plant also produces large, round seeds that are contained in a spiky pod.
The sacred lotus is an important cultural and spiritual symbol in many parts of the world. In traditional medicine, the roots, leaves, seeds, and flowers of the lotus are used to treat a variety of conditions, including digestive problems, skin ailments, and respiratory issues. The plant is purported to have anti-inflammatory, diuretic, and sedative properties. The flowers, seeds, leaves, and rhizomes (underground plant stem) of lotus are all considered edible.
Lotus - More Interactions
Lotus interacts with 209 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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