Drug & supplement interaction

Lunasin + Sulfacetamide

Sulfacetamide brand name: AK-Sulf.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lunasin and Sulfacetamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Lunasin and Sulfacetamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sulfacetamide and Lunasin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lunasin at all — not against Sulfacetamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lunasin safety at a glance

Lunasin overall Not established Lunasin is found in common foods, but the safety of concentrated supplements has not been well studied.
Pregnancy Avoid There is not enough safety data, so concentrated supplements should be avoided during pregnancy.
Breastfeeding Avoid There is not enough safety data, so concentrated supplements should be avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sulfacetamide and Lunasin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Lunasin Itself Has Been Linked To

This is not an interaction — nothing below involves Sulfacetamide. It is the side-effect record for Lunasin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Lunasin, this list is the first place to look.

  • Bloating or gas / Reduced appetite / Constipation / Stomach pain / Diarrhea / Nausea Additional detail

    “There is currently a limited amount of information on the adverse effects of lunasin. Orally, adverse effects reported in clinical research include nausea, constipation (including obstipation), diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

    “Orally, lunasin can cause nausea, constipation, diarrhea, early satiety, decreased appetite, bloating, abdominal pain, and flatulence. Two cases of obstipation requiring hospitalization have been reported following administration of lunasin.”

    Lunasin · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 104526. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
    2. 104527. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Lunasin — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Sulfacetamide’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Sulfacetamide column appears here.

Everything else you take

See Every Supplement That Interacts With Sulfacetamide

This page covers Lunasin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sulfacetamide page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Alfalfa (moderate), Angelica Archangelica (moderate), Arrach (moderate), Bergamot (moderate) and Bishop's Weed (moderate).

By severity: 19 moderate · 1 minor.

From our pharmacist’s overview on the Sulfacetamide page

“Every one of the 20 supplement interactions on file for sulfacetamide (AK-Sulf), a sulfa antibiotic used in eye drops and skin preparations, comes down to the same issue, added sun sensitivity. Sulfa drugs can make skin react more strongly to sunlight, and each ingredient below, St.”

Reviewed by 2 · Jul 18, 2026

Open the Sulfacetamide interaction page

How much people look this up

Where Lunasin and Sulfacetamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lunasin
Steady interest

#930 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sulfacetamide
Steady interest

#2,284 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lunasin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lunasin and Sulfacetamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lunasin

What is Lunasin?

  • Cholesterol and heart health
  • General immune support
  • Antioxidant support
  • Anti-inflammatory support
  • Cancer-prevention interest (unproven)

Lunasin is a small protein (peptide) found naturally in soybeans and some other seeds and grains. Laboratory and animal studies suggest it may have antioxidant, anti-inflammatory, and cholesterol-related effects, but solid human evidence is very limited. Talk with your pharmacist or doctor before using a lunasin supplement.

Seeds (most studied in soybean) · Capsules, powders, and protein extracts (often soy-derived)

An interaction check asks whether these two react with each other — it does not ask whether Lunasin is a good idea for someone in your situation. Here is what our Lunasin record says about it on its own.

Lunasin: dosing

There is no established standard dose for lunasin supplements. The amounts used in research vary, and product labels differ from brand to brand.If you choose to try a product, follow the directions on the label and do not exceed them. Because quality and purity of supplements can vary, look for brands that use independent third-party testing.

From our Lunasin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lunasin monograph & all interactions
Medication

About Sulfacetamide Ophthalmic

What Is Sulfacetamide Ophthalmic Used For?

Brand name: AK-Sulf

Sulfacetamide Sodium Ophthalmic Solution USP, 10% is used to treat conjunctivitis (pink eye) and other superficial infections on the surface of the eye caused by susceptible bacteria. These include bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella species, and others.

It is also used alongside systemic (oral or injectable) sulfonamide antibiotic therapy in the treatment of trachoma, a serious bacterial eye infection. It is important to note that this medication does not work against all types of bacteria — it does not provide adequate coverage against Neisseria species, Serratia marcescens, or Pseudomonas aeruginosa, and some staph bacteria are fully resistant to it.

Most-Reported Side Effects for Sulfacetamide

From FAERS, the FDA’s public side-effect reporting system (736 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug hypersensitivity 68 reports
Nausea 45 reports
Headache 36 reports
Dyspnea 35 reports
Rash 35 reports
See full Sulfacetamide Ophthalmic drug information
Keep checking

Other Drugs & Lunasin

Browse every other medication we’ve checked against Lunasin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lunasin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lunasin list.

See the full Lunasin interactions page
See every supplement checked against Sulfacetamide, ranked by severity
Evidence & sources

Lunasin References

The 2 references that drive our Lunasin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Bedlack RS, Wicks P, Vaughan T, et al. Lunasin does not slow ALS progression: results of an open-label, single-center, hybrid-virtual 12-month trial. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):285-293. PubMed
  2. Haddad Tabrizi S, Haddad E, Rajaram S, Oda K, Kaur A, Sabaté J. The effect of soybean lunasin on cardiometabolic risk factors: A randomized clinical trial. Subst Use Misuse. 2019;54(9):1530-1540. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lunasin and Sulfacetamide Together: Common Questions

Is it safe to take Lunasin with Sulfacetamide?
We do not list a known interaction between Lunasin and Sulfacetamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Sulfacetamide interact with any supplements?
Yes. Sulfacetamide has documented interactions with 20 supplements in our database — Lunasin is not one of them. The Sulfacetamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lunasin monograph Uses, safety profile, and every drug interaction in one place Sulfacetamide Ophthalmic drug information The full plain-English guide to this medication Sulfacetamide supplement interactions Every supplement checked against Sulfacetamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sulfacetamide and Lunasin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.