Drug & supplement interaction

Madder + Cobimetinib Fumarate

Cobimetinib Fumarate brand name: Cotellic.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Madder and Cobimetinib Fumarate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Madder and Cobimetinib Fumarate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cobimetinib Fumarate and Madder in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Madder at all — not against Cobimetinib Fumarate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Madder safety at a glance

Madder overall Avoid Some madder compounds have shown genotoxic and possible cancer-causing effects, so it is best avoided as a supplement.
Pregnancy Unsafe When used orally because it may be a potential menstrual stimulant and a genotoxin. Read the full pregnancy detail
Breastfeeding Unsafe When used orally because it is a potential genotoxin. It also can cause red-colored breast milk. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cobimetinib Fumarate and Madder? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Madder and Cobimetinib Fumarate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Madder

    “There is currently a limited amount of information available about the adverse effects of madder. Orally, madder can cause red colored urine, saliva, and perspiration (2). There is some concern that madder can stain contact lenses. Advise patients to be cautious.

    Topically, contact dermatitis has been reported while handling madder.”

    Madder · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 6002. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
    3. 20044. Castelain M, Ducombs G. Contact dermatitis from madder. Contact Dermatitis 1988;19(3):228-229. PubMed

    “A case of contact dermatitis has been reported in a woman who handled madder while working in the garden.”

    Madder · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 20044. Castelain M, Ducombs G. Contact dermatitis from madder. Contact Dermatitis 1988;19(3):228-229. PubMed

    Cobimetinib Fumarate

    Listed in the ADVERSE REACTIONS section of the FDA label for Cobimetinib Fumarate. Read the label on DailyMed ›

Reported for Madder but not commonly for Cobimetinib Fumarate: sweating.

Effects for Cobimetinib Fumarate come from the ADVERSE REACTIONS section of its FDA label; effects for Madder come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Madder in Pregnancy & Breastfeeding

Pregnancy Unsafe

When used orally because it may be a potential menstrual stimulant and a genotoxin.

Lactation Unsafe

When used orally because it is a potential genotoxin. It also can cause red-colored breast milk.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Madder or Cobimetinib Fumarate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Madder or Cobimetinib Fumarate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cobimetinib Fumarate

This page covers Madder only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cobimetinib Fumarate page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Cobimetinib Fumarate page

“If you are on cobimetinib (Cotellic) for melanoma, be strict about supplements, because this list carries real weight. The drug is cleared by the liver enzyme CYP3A4, and nearly all 138 flagged ingredients can push its blood level up or down through that pathway.”

Reviewed by 2 · Jul 18, 2026

Open the Cobimetinib Fumarate interaction page

One more smart check

Taking Madder as Part of a Dietary Supplement Product? Check It for Interactions

We hold 9 real supplement products containing Madder, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Madder. Even though Madder itself has no known interaction with Cobimetinib Fumarate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Madder and Cobimetinib Fumarate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Madder
Steady interest

#735 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cobimetinib Fumarate
Top 25%

#381 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Madder reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Madder and Cobimetinib Fumarate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Madder

What is Madder?

  • Kidney and bladder stones
  • Urinary tract complaints
  • Menstrual problems
  • Natural red dye for fabric
  • Traditional digestive remedy

Madder is a plant whose root has long been used as a red dye and in traditional medicine, mostly for kidney and urinary problems. There is very little reliable human evidence that it works, and some of its compounds have raised concerns about possible cancer-causing effects, so it is generally not recommended for use as a supplement. Talk to your pharmacist or doctor before considering it.

Rubia tinctorum · Rubiaceae · Root · Dried root, powder, capsules, tea, extracts, and natural dye

An interaction check asks whether these two react with each other — it does not ask whether Madder is a good idea for someone in your situation. Here is what our Madder record says about it on its own.

Madder: dosing

There is no established safe or effective dose of madder for any health condition. In general, we do not recommend taking madder root internally. Its safer, well-established use is as a fabric dye rather than as a supplement.

From our Madder monograph — the full record covers uses, side effects and every documented interaction.

Read the full Madder monograph & all interactions
Medication

About Cobimetinib

What Is Cobimetinib Used For?

Brand name: Cotellic

Cobimetinib is approved for two uses in adults. First, it is used in combination with another drug called vemurafenib to treat melanoma (a type of skin cancer) that cannot be surgically removed or has spread to other parts of the body — but only when the tumor carries a specific genetic change called a BRAF V600E or V600K mutation. A lab test must confirm this mutation before treatment begins.

Second, cobimetinib can be used on its own (as a single agent) to treat adults with histiocytic neoplasms — a rare group of cancers involving immune cells called histiocytes.

See full Cobimetinib drug information
Keep checking

Other Drugs & Madder

Browse every other medication we’ve checked against Madder — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Madder against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Madder list.

See the full Madder interactions page
See every supplement checked against Cobimetinib Fumarate, ranked by severity
Evidence & sources

Madder References

The 4 references that drive our Madder monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  4. Castelain M, Ducombs G. Contact dermatitis from madder. Contact Dermatitis 1988;19(3):228-229. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Madder and Cobimetinib Fumarate Together: Common Questions

Is it safe to take Madder with Cobimetinib Fumarate?
We do not list a known interaction between Madder and Cobimetinib Fumarate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Madder and Cobimetinib Fumarate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Cobimetinib Fumarate interact with any supplements?
Yes. Cobimetinib Fumarate has documented interactions with 138 supplements in our database — Madder is not one of them. The Cobimetinib Fumarate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Madder monograph Uses, safety profile, and every drug interaction in one place Cobimetinib drug information The full plain-English guide to this medication Cobimetinib Fumarate supplement interactions Every supplement checked against Cobimetinib Fumarate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cobimetinib Fumarate and Madder?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.