Methylsulfonylmethane (msm) + Memantine
Memantine brand name: Ebixa.
We found no known interaction between Methylsulfonylmethane (msm) and Memantine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Methylsulfonylmethane (msm) and Memantine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Memantine and Methylsulfonylmethane (msm) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Methylsulfonylmethane (msm) at all — not against Memantine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Methylsulfonylmethane (msm) safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Memantine
This page covers Methylsulfonylmethane (msm) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine page lists 18 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Threonine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).
By severity: 2 major · 7 moderate · 9 minor.
Where Methylsulfonylmethane (msm) and Memantine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#713 of 1,452 supplements looked up here in the last 7 days
#1,041 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Methylsulfonylmethane (msm) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Methylsulfonylmethane (msm) and Memantine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Methylsulfonylmethane (msm)
What is Methylsulfonylmethane (msm)?
- Osteoarthritis and joint pain
- Muscle soreness after exercise
- Inflammation
- Skin and hair health
- Allergy symptoms
Methylsulfonylmethane (MSM) is a natural sulfur compound that people most often take for joint pain and exercise recovery. Some early research suggests it may modestly help osteoarthritis symptoms, but the evidence is limited and more study is needed. It appears generally well tolerated in the short term, but talk with your pharmacist or doctor before starting it.
Not applicable (a sulfur-containing compound) · Capsules, tablets, powders, creams, and combination joint supplements
An interaction check asks whether these two react with each other — it does not ask whether Methylsulfonylmethane (msm) is a good idea for someone in your situation. Here is what our Methylsulfonylmethane (msm) record says about it on its own.
Methylsulfonylmethane (msm): dosing
There is no official or standardized dose of MSM. Studies have used a wide range of amounts, and the best dose is not clearly established.The safest approach is to follow the directions on the product label and not take more than recommended. They can help you decide if it is appropriate and what amount is reasonable.
From our Methylsulfonylmethane (msm) monograph — the full record covers uses, side effects and every documented interaction.
About Memantine
What Is Memantine Used For?
Brand name: Ebixa
Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use.
It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.
Other Drugs & Methylsulfonylmethane (msm)
Browse every other medication we’ve checked against Methylsulfonylmethane (msm) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Methylsulfonylmethane (msm) against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Aspirin ›
- Ivermectin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Acetaminophen ›
- Tadalafil ›
- Clopidogrel ›
- Atorvastatin ›
- Valacyclovir ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Ibuprofen ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Warfarin Sodium ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Bupropion ›
- Metformin ›
- Acyclovir ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Methotrexate ›
- Lamotrigine ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Omeprazole ›
- Quetiapine ›
- Methylene Blue ›
- Amlodipine Besylate ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Naproxen ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Methylsulfonylmethane (msm) list.
Methylsulfonylmethane (msm) References
The 4 references that drive our Methylsulfonylmethane (msm) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-73. PubMed
- Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. PubMed
- Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286-94. PubMed
- Hwang JC, Khine KT, Lee JC, Boyer DS, Francis BA. Methyl-sulfonyl-methane (MSM)-induced acute angle closure. J Glaucoma. 2015 Apr-May;24(4):e28-30. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Methylsulfonylmethane (msm) and Memantine Together: Common Questions
Is it safe to take Methylsulfonylmethane (msm) with Memantine?
Do Methylsulfonylmethane (msm) and Memantine have any of the same side effects?
Does Memantine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.