Mommy's Bliss Gripe Water - Bromocriptine Interaction

Interaction Details

Bromocriptine is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates

Mommy's Bliss Gripe Water contains fennel seed. Theoretically, fennel might increase levels of drugs metabolized by CYP3A4. However, this has only been seen in vitro (i.e., in a lab setting) and has not been reported in humans. Additionally, the amount of fennel seed contained in Mommy's Bliss Gripe water is very low, and clinically significant interactions here are thought to be unlikely.

Interaction Rating

Likelihood of Occurrence

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Pharmacist Analysis

Depending on the dose of Mommy's Bliss Gripe Water given (which depends on age), the amount of fennel seed ingested by the infant will be between 1mg and 5mg.

This small amount is very unlikely to cause a clinically significant interaction with any other drug that is metabolized via CYP3A4.

Nevertheless, the theoretical interaction is that fennel, by decreasing the activity of this enzyme, could increase the concentrations of drugs metabolized by it.

The interaction is important to be aware of but will likely not cause any issues.

References

• Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. PubMed
• Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator. PubMed

Bromocriptine Overview

• Bromocriptine (Parlodel) is used to treat symptoms of hyperprolactinemia (high levels of a natural substance called prolactin in the body) including lack of menstrual periods, discharge from the nipples, infertility (difficulty becoming pregnant) and hypogonadism (low levels of certain natural substances needed for normal development and sexual function). Bromocriptine (Parlodel) may be used to treat hyperprolactinemia caused by certain types of tumors that produce prolactin, and may shrink these tumors. Bromocriptine (Parlodel) is also used alone or with other treatments to treat acromegaly (condition in which there is too much growth hormone in the body) and Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Bromocriptine (Cycloset) is used with a diet and exercise program and sometimes with other medications to control blood sugar levels in people with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Bromocriptine (Cycloset) is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Bromocriptine is in a class of medications called dopamine receptor agonists. It treats hyperprolactinemia by decreasing the amount of prolactin in the body. It treats acromegaly by decreasing the amount of growth hormone in the body. It treats Parkinson's disease by stimulating the nerves that control movement. The way bromocriptine works to treat diabetes is not known.

Mommy's Bliss Gripe Water - More Interactions

Mommy's Bliss Gripe Water interacts with 788 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.