Mommy's Bliss Gripe Water - Methotrexate Interaction
Herbal: Mommy's Bliss Gripe Water
Drug: Methotrexate
Brand names:
Rheumatrex, Otrexup, Rasuvo, Reditrex
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 29, 2025
Interaction Details
There were no interactions found between Methotrexate and Mommy's Bliss Gripe Water. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Pharmacist Analysis
Mommy's Bliss Gripe Water is intended to help treat colicky infants and soothe gastrointestinal discomfort.
There is no 'standardized' gripe water formula, but generally, gripe water formulas contain a blend of herbal ingredients. Mommy's Bliss contains the following:
- Organic Fennel Seed
- Organic Ginger Root
- Purified Water
- Vegetable Glycerin
- Citrus Bioflavonoid Extract
- Citric Acid
- Sodium Bicarbonate
- Potassium Sorbate
- Natural Fennel Flavor
It is important to note that Mommy's Bliss Gripe Water contains sodium bicarbonate, which is commonly known as baking soda. It is a well-known acid neutralizer and likely plays a key role in relieving colic symptoms if excess acid is at least partially responsible for the symptoms being experienced.
While there is no interaction between Mommy's Bliss Gripe Water and the drug in question here, it is important to note that Mommy's Bliss Gripe Water does have some theoretical ones with other drugs simply based on the fact that two herbals in the product, ginger, and fennel, can affect the metabolism and/or effects of some substances.
We have more details on specific drug-herbal interaction pages.
- Dr. Brian Staiger, PharmDMommy's Bliss Gripe Water Overview
Mommy's Bliss Gripe Water is an over-the-counter product used to soothe colicky babies and infants. It is important to note that 'Gripe water' has been used traditionally since at least the 1800s to help treat colic and gastrointestinal discomfort in infants but 'gripe water' is not a standardized formula. Generally, it is a liquid made from a combination of water and various herbs, such as ginger, fennel, chamomile, licorice, and cinnamon, among others. Some varieties may also contain alcohol or sugar. Mommy's Bliss Gripe water contains fennel seed and ginger. It does not contain sugar or alcohol.
Methotrexate Overview
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Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate is also used along with rest, physical therapy, and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications. Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells). Methotrexate is in a class of medications called antimetabolites. Methotrexate treats cancer by slowing the growth of cancer cells. Methotrexate treats psoriasis by slowing the growth of skin cells to stop scales from forming. Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system.
Mommy's Bliss Gripe Water - More Interactions
Mommy's Bliss Gripe Water interacts with 788 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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