Drug & supplement interaction

Muira Puama + Leuprolide acetate

Leuprolide acetate brand names: Lupron, Eligard, Fensolvi.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Muira Puama and Leuprolide acetate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Muira Puama and Leuprolide acetate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leuprolide acetate and Muira Puama in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Muira Puama at all — not against Leuprolide acetate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Muira Puama safety at a glance

Muira Puama overall Use caution Generally used in small amounts traditionally, but human safety data are limited.
Pregnancy Avoid Not enough safety information; avoid during pregnancy.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leuprolide acetate and Muira Puama? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Leuprolide acetate’s Own FDA Label Lists

This is not an interaction — none of it involves Muira Puama. These are the most notable effects listed in the ADVERSE REACTIONS section of Leuprolide acetate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Thoughts of self-harm Worth acting on
  • Bone thinning Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Trouble passing urine Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on

Showing the 10 most notable of 37 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Leuprolide acetate. Read the label on DailyMed › Where a percentage is shown, it is the share of 77,113 voluntary FDA FAERS reports for Leuprolide acetate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Muira Puama’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Muira Puama side to compare — that is a limit of the record, not a statement that Muira Puama has no side effects.

One more smart check

Taking Muira Puama as Part of a Dietary Supplement Product? Check It for Interactions

We hold 698 real supplement products containing Muira Puama, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Muira Puama. Even though Muira Puama itself has no known interaction with Leuprolide acetate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Muira Puama and Leuprolide acetate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Muira Puama
Top 25%

#225 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leuprolide acetate
Top half

#729 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Muira Puama reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Muira Puama and Leuprolide acetate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Muira Puama

What is Muira Puama?

  • Low libido
  • Erectile difficulty
  • Sexual performance
  • Fatigue and low energy
  • General tonic for stress

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limited, so its benefits are not well proven, and there is little information on its long-term safety. Talk with your pharmacist or doctor before trying it, especially if you have a health condition or take other medicines.

Ptychopetalum olacoides · Olacaceae · Roots and bark (sometimes wood) · Capsules, tinctures, liquid extracts, teas, and powders

An interaction check asks whether these two react with each other — it does not ask whether Muira Puama is a good idea for someone in your situation. Here is what our Muira Puama record says about it on its own.

Muira Puama: dosing

There is no well-established or standardized dose for muira puama. Products differ in form (capsule, tincture, tea) and in how concentrated they are, so amounts on labels vary widely.The safest approach is to follow the directions on the specific product you buy and to start low.

From our Muira Puama monograph — the full record covers uses, side effects and every documented interaction.

Read the full Muira Puama monograph & all interactions
Medication

About Leuprolide Injection

What Is Leuprolide Injection Used For?

Brand names: Lupron, Eligard, Fensolvi

Leuprolide injection is used for two main categories of conditions. Fensolvi is specifically approved to treat central precocious puberty (CPP) — early puberty — in children 2 years of age and older.

Several leuprolide injection products, including Eligard and Vabrinty, are used in the treatment of advanced prostate cancer in adult men. These products work by lowering testosterone to very low levels, which helps slow the growth of prostate cancer.

Most-Reported Side Effects for Leuprolide acetate

From FAERS, the FDA’s public side-effect reporting system (77,113 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hot flush 9,564 reports
Intercepted product preparation error 9,222 reports
Syringe issue 7,900 reports
Device leakage 6,230 reports
Fatigue 5,098 reports
See full Leuprolide Injection drug information
Keep checking

Other Drugs & Muira Puama

Browse every other medication we’ve checked against Muira Puama — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Muira Puama against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Muira Puama list.

See the full Muira Puama interactions page
See every supplement checked against Leuprolide acetate, ranked by severity
Evidence & sources

Muira Puama References

The 2 references that drive our Muira Puama monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Waynberg, J. and Brewer, S. Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther 2000;17(5):255-262. PubMed
  2. Nguyen S, Rajfer J, Shaheen M. Safety and efficacy of daily Revactin in men with erectile dysfunction: a 3-month pilot study. Transl Androl Urol. 2018;7(2):266-73. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Muira Puama and Leuprolide acetate Together: Common Questions

Is it safe to take Muira Puama with Leuprolide acetate?
We do not list a known interaction between Muira Puama and Leuprolide acetate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Muira Puama monograph Uses, safety profile, and every drug interaction in one place Leuprolide Injection drug information The full plain-English guide to this medication Leuprolide acetate supplement interactions Every supplement checked against Leuprolide acetate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leuprolide acetate and Muira Puama?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.