Drug & supplement interaction

Ornithine Ketoglutarate (okg) + Mitotane

Mitotane brand name: Lysodren.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ornithine Ketoglutarate (okg) and Mitotane in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mitotane states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ornithine Ketoglutarate (okg) and Mitotane

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mitotane and Ornithine Ketoglutarate (okg) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ornithine Ketoglutarate (okg) at all — not against Mitotane, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ornithine Ketoglutarate (okg) safety at a glance

Ornithine Ketoglut... overall Use caution Generally well tolerated in short-term clinical studies, but long-term safety as a daily supplement is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mitotane and Ornithine Ketoglutarate (okg)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Ornithine Ketoglutarate (okg) and Mitotane May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Itching Additional detail

    Ornithine Ketoglutarate (okg)

    “Orally, pruritus has occurred rarely.”

    Ornithine Ketoglutarate (okg) · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 67466. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed

    Mitotane

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitotane. Read the label on DailyMed ›

  • Diarrhea / Vomiting / Nausea Additional detail

    Ornithine Ketoglutarate (okg)

    “Orally, the most common adverse effects are gastrointestinal in nature, including abdominal pain, bloating, diarrhea, nausea, and vomiting.”

    Ornithine Ketoglutarate (okg) · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 67449. Karsegard, V. L., Raguso, C. A., Genton, L., Hirschel, B., and Pichard, C. L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004;20(6):515-520.
    2. 67453. Meaume, S., Kerihuel, J. C., Constans, T., Teot, L., Lerebours, E., Kern, J., and Bourdel, Marchasson, I. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J.Nutr.H PubMed
    3. 67466. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed

    Mitotane

    Listed in the ADVERSE REACTIONS section of the FDA label for Mitotane. Read the label on DailyMed ›

Reported for Ornithine Ketoglutarate (okg) but not commonly for Mitotane: stomach pain and bloating or gas.

Effects for Mitotane come from the ADVERSE REACTIONS section of its FDA label; effects for Ornithine Ketoglutarate (okg) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Mitotane Products Have a Food Rule — Ornithine Ketoglutarate (okg) Should Not Break It

At least one FDA label for a product containing Mitotane says to take it with food. If you take Ornithine Ketoglutarate (okg) on an empty stomach out of habit, keep them separate — and take Mitotane with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mitotane products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION The recommended initial dose of LYSODREN is 2000 mg to 6000 mg orally, in three or four divided doses per day with food.

From the Dosage and Administration section of the FDA label we read for Mitotane — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Mitotane

This page covers Ornithine Ketoglutarate (okg) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mitotane page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Mitotane page

“Mitotane (Lysodren) is chemotherapy for adrenal cancer, and doses are adjusted based on blood levels, so a supplement list like this one deserves genuine attention rather than a shrug. All 17 entries work the same basic way, by changing how much mitotane your gut actually takes in.”

Reviewed by 2 · Jul 18, 2026

Open the Mitotane interaction page

How much people look this up

Where Ornithine Ketoglutarate (okg) and Mitotane Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ornithine Ketoglutarate (okg)
Steady interest

#1,391 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mitotane
Top half

#1,137 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ornithine Ketoglutarate (okg) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ornithine Ketoglutarate (okg) and Mitotane records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ornithine Ketoglutarate (okg)

What is Ornithine Ketoglutarate (okg)?

  • Wound healing and recovery from injury
  • Muscle preservation in older or hospitalized adults
  • Sports and athletic performance
  • Recovery from burns or surgery
  • Support during malnutrition or critical illness

Ornithine ketoglutarate (OKG) is a compound made by combining the amino acids ornithine and alpha-ketoglutarate, and it has mainly been studied in hospital settings for wound healing, burns, and malnutrition. Evidence for everyday use, such as sports performance, is limited and not convincing. Talk to your pharmacist or doctor before using it, especially if you have a health condition.

Not applicable (a synthesized amino acid salt) · Powder, capsules, tablets, and as part of clinical nutrition formulas

An interaction check asks whether these two react with each other — it does not ask whether Ornithine Ketoglutarate (okg) is a good idea for someone in your situation. Here is what our Ornithine Ketoglutarate (okg) record says about it on its own.

Ornithine Ketoglutarate (okg): dosing

There is no official standardized dose of OKG for general use. In clinical studies, doses were chosen by researchers and given to specific patient groups, often under medical care.If you use a supplement, follow the directions on the product label and do not assume more is better.

From our Ornithine Ketoglutarate (okg) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ornithine Ketoglutarate (okg) monograph & all interactions
Medication

About Mitotane

What Is Mitotane Used For?

Brand name: Lysodren

Lysodren (mitotane) tablets are indicated for the treatment of inoperable adrenocortical carcinoma (ACC) — a rare cancer of the adrenal gland's outer layer (the cortex). It can be used whether or not the tumor is actively producing hormones (functional or nonfunctional).

Because the cancer cannot be removed surgically in these patients, Lysodren works to suppress and damage the adrenal tissue itself, helping to control the disease.

See full Mitotane drug information
Keep checking

Other Drugs & Ornithine Ketoglutarate (okg)

Browse every other medication we’ve checked against Ornithine Ketoglutarate (okg) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Ornithine Ketoglutarate (okg) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Ornithine Ketoglutarate (okg) list.

See the full Ornithine Ketoglutarate (okg) interactions page
See every supplement checked against Mitotane, ranked by severity
Evidence & sources

Ornithine Ketoglutarate (okg) References

The 3 references that drive our Ornithine Ketoglutarate (okg) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Karsegard, V. L., Raguso, C. A., Genton, L., Hirschel, B., and Pichard, C. L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004;20(6):515-520.
  2. Meaume, S., Kerihuel, J. C., Constans, T., Teot, L., Lerebours, E., Kern, J., and Bourdel, Marchasson, I. Efficacy and safety of ornithine alpha-ketoglutarate in heel pressure ulcers in elderly patients: results of a randomized controlled trial. J.Nutr.H PubMed
  3. Brocker, P., Vellas, B., Albarede, J. L., and Poynard, T. A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects. Age Ageing 1994;23(4):303-306. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ornithine Ketoglutarate (okg) and Mitotane Together: Common Questions

Is it safe to take Ornithine Ketoglutarate (okg) with Mitotane?
We do not list a known interaction between Ornithine Ketoglutarate (okg) and Mitotane. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ornithine Ketoglutarate (okg) and Mitotane have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Ornithine Ketoglutarate (okg) and Mitotane at the same time of day?
At least one FDA label for a product containing Mitotane says to take it with food. If you take Ornithine Ketoglutarate (okg) on an empty stomach out of habit, keep them separate and take Mitotane with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Mitotane products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Mitotane interact with any supplements?
Yes. Mitotane has documented interactions with 17 supplements in our database — Ornithine Ketoglutarate (okg) is not one of them. The Mitotane interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ornithine Ketoglutarate (okg) monograph Uses, safety profile, and every drug interaction in one place Mitotane drug information The full plain-English guide to this medication Mitotane supplement interactions Every supplement checked against Mitotane, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mitotane and Ornithine Ketoglutarate (okg)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.